Detalhe da pesquisa
1.
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Bioorg Med Chem Lett
; 29(11): 1380-1385, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30952592
2.
Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Bioorg Med Chem Lett
; 29(10): 1182-1186, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926247
3.
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(21): 4945-4949, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978966
4.
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(22): 5437-43, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318999
5.
Disubstituted pyrimidines as Lck inhibitors.
Bioorg Med Chem Lett
; 19(18): 5440-3, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19674899
6.
Identification of DGAT2 Inhibitors Using Mass Spectrometry.
J Biomol Screen
; 21(2): 117-26, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403520
7.
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
J Med Chem
; 59(5): 1818-29, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26871940
8.
Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
J Med Chem
; 59(24): 11039-11049, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002958
9.
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 5(10): 1082-7, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349648
10.
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 4(8): 773-8, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900745
11.
1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.
J Med Chem
; 55(7): 2945-59, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22364528
12.
The catalytic flexibility of tRNAIle-lysidine synthetase can generate alternative tRNA substrates for isoleucyl-tRNA synthetase.
J Biol Chem
; 284(15): 9656-62, 2009 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19233850
13.
A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor protease.
Proc Natl Acad Sci U S A
; 99(10): 6603-6, 2002 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11997440