[Increased levels of RANTES in induced sputum of chronic asthma but not in seasonal grass pollen-induced rhinitis]. / Podwyzszone stezenia RANTES w indukowanej plwocinie w przewleklej astmie, ale nie w sezonowym alergicznym niezycie nosa.

BACKGROUND: [corrected] Allergic rhinitis is one of risk factors for development of allergic asthma. METHODS: 9 patients with asthma, 16 patients with seasonal allergic rhinitis (SAR) due to grass or rye pollen sensitization and 17 healthy control subjects were recruited to the study. SAR patients were identified by history, skinprick test, specific IgE and positive nasal allergen challenge. Every subject underwent the methacholine bronchial provocation test and sputum induction. Levels of RANTES were measured in supernatant of induced sputum. RESULTS: Increased percentage of eosinophils in induced sputum in asthma compared to control group (p=0.01) but not in SAR patients compared to healthy subjects (p=0.13) were found. Similarly, asthmatic patients (p=0.01) but not SAR patients had increased levels of RANTES in sputum compared to healthy subjects. CONCLUSION: Increased levels of RANTES in induced sputum of patients with chronic asthma but not in SAR patients indicate that RANTES is important in pathogenesis of chronic airway inflammation.

[Cystic fibrosis and pregnancy]. / Mukowiscydoza a ciaza.

The aim of this paper is to present a case of 25-year-old pregnant woman admitted to hospital because of severe cystic fibrosis, unstable diabetes and paranoid syndrome. Due to the team consisted of pulmonologist, gynaecologist and kinesipathist a healthy baby was born. The condition of the woman after childbirth was stable. The presented case is a rare example in literature concerning the case of pregnant woman suffering from mucoviscidosis as well as the trial of establishing the guidelines of management in these cases.