Detalhe da pesquisa
1.
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
Bioorg Med Chem Lett
; 22(4): 1716-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22277280
2.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²âº channel blockers with analgesic activity.
Bioorg Med Chem
; 20(13): 4128-39, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22626552
3.
Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.
Eur J Pharmacol
; 580(3): 314-21, 2008 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18054908
4.
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R).
Bioorg Med Chem Lett
; 18(6): 2162-6, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18272364
5.
Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation.
Neuropharmacology
; 50(5): 521-31, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16324724
6.
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
J Med Chem
; 49(23): 6726-31, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154503
7.
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
J Med Chem
; 49(17): 5093-109, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913699
8.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
J Med Chem
; 49(25): 7450-65, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149874
9.
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels.
Pain
; 117(1-2): 88-96, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061325
10.
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Neuropharmacology
; 49(1): 112-21, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15992586
11.
Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.
J Med Chem
; 48(23): 7374-88, 2005 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16279797
12.
Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor.
Pain
; 96(1-2): 107-18, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11932067
13.
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
J Med Chem
; 47(15): 3853-64, 2004 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15239663
14.
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
J Med Chem
; 47(9): 2348-55, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084133
15.
[3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor.
Eur J Pharmacol
; 497(2): 147-54, 2004 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15306199
16.
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.
Eur J Med Chem
; 38(3): 245-52, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12667691
17.
A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats.
Biochem Pharmacol
; 83(3): 406-18, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22153861
18.
Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.
J Med Chem
; 52(1): 170-80, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19072118
19.
Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.
Bioorg Med Chem Lett
; 17(15): 4303-7, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17532216
20.
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem
; 15(4): 1586-605, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17197188