Detalhe da pesquisa
1.
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.
Bioorg Med Chem Lett
; 23(24): 6688-94, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24210503
2.
Plate-based diversity selection based on empirical HTS data to enhance the number of hits and their chemical diversity.
J Biomol Screen
; 14(6): 690-9, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19531667
3.
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
J Med Chem
; 51(8): 2481-91, 2008 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18357974
4.
The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering.
Arch Biochem Biophys
; 480(1): 51-7, 2008 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18823937
5.
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
ACS Med Chem Lett
; 7(11): 999-1004, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882198
6.
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
ACS Med Chem Lett
; 7(11): 977-982, 2016 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27882194
7.
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
J Med Chem
; 57(24): 10527-43, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25431858
8.
A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.
Protein Sci
; 19(11): 2096-109, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20799349
9.
How similar are similarity searching methods? A principal component analysis of molecular descriptor space.
J Chem Inf Model
; 49(1): 108-19, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19123924
10.
Mapping adverse drug reactions in chemical space.
J Med Chem
; 52(9): 3103-7, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19378990
11.
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis.
J Chem Inf Model
; 49(2): 308-17, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19434832
12.
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.
J Comput Aided Mol Des
; 20(3): 159-78, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16645791