RESUMO
Leiomyosarcoma is a rare skin tumor, most common in white men in the fifth to eighth decades of life. Primary tumors are classified in dermal or subcutaneous, that differ by clinical and prognostic features. They may appear on any site of the body, but are rare on the face. A 54-year-old female was admitted with a 5cm exophytic nodular lesion of 8 months duration on the right cheek, site of previous chronic radiodermatitis. Histopathology revealed spindle-shaped cell neoplasia, positive for smooth muscle actin on immunohistochemistry. Cutaneous leiomyosarcomas on the face are rare and may occur in previously irradiated areas. Immunohistochemistry is mandatory for an accurate diagnosis. Its similarity with other tumors may complicate the diagnosis, with delay expansion of the tumor.
Assuntos
Neoplasias Faciais/patologia , Leiomiossarcoma/patologia , Neoplasias Cutâneas/patologia , Actinas/análise , Diagnóstico Diferencial , Neoplasias Faciais/diagnóstico , Feminino , Humanos , Imuno-Histoquímica , Leiomiossarcoma/diagnóstico , Pessoa de Meia-Idade , Músculo Liso/patologia , Doenças Raras/patologia , Neoplasias Cutâneas/diagnósticoRESUMO
Abstract: Leiomyosarcoma is a rare skin tumor, most common in white men in the fifth to eighth decades of life. Primary tumors are classified in dermal or subcutaneous, that differ by clinical and prognostic features. They may appear on any site of the body, but are rare on the face. A 54-year-old female was admitted with a 5cm exophytic nodular lesion of 8 months duration on the right cheek, site of previous chronic radiodermatitis. Histopathology revealed spindle-shaped cell neoplasia, positive for smooth muscle actin on immunohistochemistry. Cutaneous leiomyosarcomas on the face are rare and may occur in previously irradiated areas. Immunohistochemistry is mandatory for an accurate diagnosis. Its similarity with other tumors may complicate the diagnosis, with delay expansion of the tumor.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Neoplasias Faciais/patologia , Leiomiossarcoma/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Faciais/diagnóstico , Imuno-Histoquímica , Actinas/análise , Doenças Raras/patologia , Diagnóstico Diferencial , Leiomiossarcoma/diagnóstico , Músculo Liso/patologiaAssuntos
Síndrome de Hipersensibilidade a Medicamentos/sangue , Síndrome de Hipersensibilidade a Medicamentos/terapia , Adolescente , Adulto , Idoso , Brasil , Criança , Síndrome de Hipersensibilidade a Medicamentos/complicações , Eosinofilia/etiologia , Feminino , Febre/etiologia , Hospitais de Ensino , Humanos , Hiperbilirrubinemia/etiologia , Tempo de Internação , Leucocitose/etiologia , Masculino , Pessoa de Meia-Idade , Transaminases/sangue , Adulto JovemRESUMO
ABSTRACTBowen's disease is a squamous cell carcinoma in situ with the potential to turn into invasive carcinoma. Pigmented Bowen's disease is an unusual variant, with few reported in the literature, and becomes a problem in the differential diagnosis with other pigmented tumors. We reported the case of a white female patient, 73-year-old, with a brownish asymmetric plaque, with more than one color, in the right upper limb, with 2-years of follow up.
RESUMOA doença de Bowen é um carcinoma espinocelular in situ com potencial para transformar-se em invasivo. Ela é pigmentada, uma variante rara, possui poucos relatos na literatura e torna-se um problema no diagnóstico diferencial com outros tumores pigmentados. Relatamos o caso de uma paciente de 73 anos, branca, com uma placa acastanhada, assimétrica, com mais de uma cor, em membro superior direito, com evolução de dois anos.