RESUMO
Natural cyclopeptides are hot spots in chemical and pharmaceutical fields because of the wide spreading bio-resources, complex molecular structures and various bioactivities. Bio-producers of cyclopeptides distribute over almost every kingdom from bacteria to plants and animals. Many cyclopeptides contain non-coded amino acids and non-pepditic bonds. Most exciting characteristic of cyclopeptides is a range of interesting bioactivities such as antibiotics gramicidin-S (2), vancomycin (3) and daptomycin (4), immunosuppressive cyclosporin-A (1) and astin-C (8), and anti-tumor aplidine (5), RA-V (6) and RA-VII (7). Compounds 1-4 are being used in clinics; compounds 5-8 are in the stages of clinical trial or as a candidate for drug research. In this review, the progress in chemical and bioactive studies on these important natural bioactive cyclopeptides 1-8 are introduced, mainly including discovery, bioactivity, mechanism, QSAR and synthesis.
Assuntos
Imunossupressores , Peptídeos Cíclicos , Animais , Antibacterianos/síntese química , Antibacterianos/química , Antibacterianos/farmacologia , Antineoplásicos/síntese química , Antineoplásicos/química , Antineoplásicos/uso terapêutico , Ciclosporina/química , Ciclosporina/farmacologia , Daptomicina/síntese química , Daptomicina/química , Daptomicina/farmacologia , Depsipeptídeos/síntese química , Depsipeptídeos/química , Depsipeptídeos/uso terapêutico , Gramicidina/síntese química , Gramicidina/química , Gramicidina/farmacologia , Humanos , Terapia de Imunossupressão , Imunossupressores/síntese química , Imunossupressores/química , Imunossupressores/farmacologia , Estrutura Molecular , Neoplasias/tratamento farmacológico , Peptídeos Cíclicos/síntese química , Peptídeos Cíclicos/química , Peptídeos Cíclicos/farmacologia , Peptídeos Cíclicos/uso terapêutico , Relação Quantitativa Estrutura-Atividade , Vancomicina/síntese química , Vancomicina/química , Vancomicina/farmacologiaRESUMO
The petroleum ether fraction of ethanol extract of Acorus tatarinowii were separated by column chromatography and recrystallization to afford seven compounds. On the spectroscopic analysis, they were identified as 1-hydroxy-7(11),9-guaiadien-8-one (1), calamenone(2), cis-asarone(3), chrysophanol (4), physcion (5), emodin (6), (+)-galbacin (7). Compound 1 is a new compound. Compounds 4-7 were isolated from this plant for the first time.