RESUMO
Dextropropoxyphene (DP) and norpropoxyphene (NP) are commonly used in the treatment of postpartum pain. The drug is widely prescribed in Europe and Canada and has been recently approved for use in the U.S. Its safety during breastfeeding, however, has not been fully established. Very few reports on its effects on neonates have been published. We report here the case of a mother treated with DP (6 capsules a day for 10 days) while she was breastfeeding. On day 7, her baby was lethargic and had difficulties with breastfeeding, which led to early weaning. The correlation between side effects observed in the infant and DP was made retrospectively by measuring DP and NP hair concentrations in the mother-infant pair with liquid chromatography-tandem mass spectrometry. Breastfeeding mothers taking DP expose their infants to high doses of DP and NP. In agreement with previously published reports, these data indicate that acetaminophen and nonsteroidal antiinflammatories are preferable for analgesia during breastfeeding. Breastfeeding should be encouraged under most circumstances, and if the mother takes any treatment for pain, a commonly prescribed drug with pharmacologic data available must be used.
Assuntos
Analgésicos Opioides/efeitos adversos , Analgésicos Opioides/análise , Aleitamento Materno , Dextropropoxifeno/análogos & derivados , Dextropropoxifeno/efeitos adversos , Dextropropoxifeno/análise , Cabelo/química , Adulto , Cromatografia Líquida de Alta Pressão , Feminino , Humanos , Recém-Nascido , Dor/tratamento farmacológico , Período Pós-Parto , Gravidez , Estudos Retrospectivos , Espectrometria de Massas em TandemRESUMO
INTRODUCTION: The first exchanges between a newborn baby and its mother are essential. Any separation can have negative effects on the establishment of the first connections as well as breastfeeding. OBJECTIVE: To establish the current state of management of healthy newborn babies in the delivery room and assess the reasons for possible separation and the feelings of mothers facing this separation. MATERIALS AND METHODS: Observational descriptive single-center study, made up of two parts: 1/a questionnaire given to the mothers, postpartum; 2/the collection of data concerning the transfer of healthy newborn babies to the nursery. RESULTS: The study took place over a period of 8 weeks. Eighty-five mothers were interviewed. Seventy-two percent of the newborn babies left the delivery room during the first 2h of life. For 67 %, the duration of skin-to-skin contact was less than 1h. For 49 %, the main reason was the performance of routine care. The mothers were satisfied with the care provided in the delivery room. CONCLUSION: Too many healthy newborn babies are separated from their mothers during the first 2h of life, mainly for routine care. Skin-to-skin contact must be part of the physiological reception of newborn babies in the delivery room. The medical staff and parents must be informed of this aspect and its beneficial effects. It is necessary to reconsider the organization of practices to propose a management system that promotes the establishment of a strong mother-child bond.
RESUMO
OBJECTIVE: Is it reasonable to care for children born under 26 gestational weeks (GW)? To answer this question, we compared outcome at 5 years of 2 groups of children:less or equal to 25 GW+6 days (group 1) and 26-27 GW+6 days (group 2). METHOD: Retrospective study on extremely preterm children hospitalized in our center between 1999 and 2001. Perinatal data were obtained from medical reports. Five-year outcome was evaluated by questionnaire sent to Centers for Early Medicosocial Intervention, pediatricians or the child's parents. The children were classified according to their disability: none, minor or major. Progression was considered favorable if the child survived with or without minor disability and unfavorable if the child had died or had major disability. RESULTS: One hundred and sixty-six preterm babies were recorded. In group 1 (n=63), mortality was higher (58% vs 29%; p=0.0002), a neurologic cause was often responsible for death (36% vs 19%; p=0.018), a high level of intracranial hemorrhage was more frequent (35% vs 19%; p=0.002), and a decision to stop healthcare more often made (35% vs 18%; p=0.01) than in group 2 (n=103). Among the 99 survivors, 78 were being followed up at 5 years of age. In terms of disability, no difference was observed between group 1 (n=21) and group 2 (n=57). Including deaths, the risk for unfavorable progression was higher in group 1 (64% vs 41%; p=0.008). CONCLUSION: The progression of under 26-GW preterm babies is more often unfavorable than the progression of babies born 26-27 GW+6 days. However, given the low number of patients, no significant difference was made concerning the prognosis at 5 years between the survivors of the 2 groups.