COVID-19 pre-procedural testing strategy and early outcomes at a large tertiary care children's hospital.

PURPOSE: With the emergence of the coronavirus disease-2019 (COVID-19) pandemic, institutions were tasked with developing individualized pre-procedural testing strategies that allowed for re-initiation of elective procedures within national and state guidelines. This report describes the experience of a single US children's hospital (Children's Wisconsin, CW) in developing a universal pre-procedural COVID-19 testing protocol and reports early outcomes. METHODS: The CW pre-procedural COVID-19 response began with the creation of a multi-disciplinary taskforce that sought to develop a strategy for universal pre-procedural COVID-19 testing which (1) maximized patient safety, (2) prevented in-hospital viral transmission, (3) conserved resources, and (4) allowed for resumption of procedural care within institutional capacity. RESULTS: Of 11,209 general anesthetics performed at CW from March 16, 2020 to October 31, 2020, 11,150 patients (99.5%) underwent pre-procedural COVID-19 testing. Overall, 1.4% of pre-procedural patients tested positive for COVID-19. By June 2020, CW was operating at near-normal procedural volume and there were no documented cases of in-hospital viral transmission. Only 0.5% of procedures were performed under augmented COVID-19 precautions (negative pressure environment and highest-level personal protective equipment). CONCLUSION: CW successfully developed a multi-disciplinary pre-procedural COVID-19 testing protocol that enabled resumption of near-normal procedural volume within three months while limiting in-hospital viral transmission and resource use.

Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.

BACKGROUND: Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents. In a double-blind, randomized, controlled trial, we examined whether gabapentin decreases postoperative opioid consumption for pediatric spinal fusion patients with idiopathic scoliosis. METHODS: Patients, aged 9 to 18 years, received preoperative gabapentin (15 mg/kg, treatment) or placebo. Anesthesia was standardized. After surgery, all patients received standardized patient-controlled analgesia opioid and continued on either gabapentin (5 mg/kg) or placebo 3 times per day for 5 days. Opioid use was calculated in mg/kg/time intervals. Pain scores and opioid side effects were recorded. RESULTS: Data from 59 patients (30 placebo and 29 gabapentin) did not differ in demographics. Total morphine consumption (mg/kg/h +/- SD) was significantly lower in the gabapentin group in the recovery room (0.044 +/- 0.017 vs 0.064 +/- 0.031, P = 0.003), postoperative day 1 (0.046 +/- 0.016 vs 0.055 +/- 0.017, P = 0.051), and postoperative day 2 (0.036 +/- 0.016 vs 0.047 +/- 0.019, P = 0.018). In addition, gabapentin significantly reduced first pain scores in the recovery room (2.5 +/- 2.8 vs 6.0 +/- 2.4, P < 0.001) and the morning after surgery (3.2 +/- 2.6 vs 5.0 +/- 2.2, P < 0.05), but otherwise pain scores were not significantly different. There were no differences in opioid-related side effects over the course of the study. CONCLUSION: Perioperative oral gabapentin reduced the amount of morphine used for postoperative pain after spinal fusion surgery, but not overall opioid-related side effects. Initial pain scores were lower in the treatment group. Perioperative use of gabapentin seems to be an effective adjunct to improve pain control in the early stages of recovery in children and adolescents undergoing spinal fusion.

Development of a 3-Dimensional Back Contour Imaging System for Monitoring Scoliosis Progression in Children.

STUDY DESIGN: Control study. OBJECTIVES: To present a new surface topography system capable of taking 3-dimensional (3D) spine measurements, to establish baseline values for the measured parameters in a typically developing population, and to determine the intra-rater and inter-rater reproducibility of these parameters. SUMMARY OF BACKGROUND DATA: Cumulative exposure to radiation from diagnostic radiographs increases patient risk for cancer development. There is a need for noninvasive and non-radiographic tools to accurately and reproducibly measure spine deformity and track scoliosis progression. METHODS: We measured 10 typically developing subjects with the new Milwaukee Topography System, which is composed of 2 electromagnetic markers, an electronic processing unit, a handheld laser scanner, a software package, and a desktop computer. Two investigators separately scanned the same subjects multiple times, yielding a total of 4 scans per subject per investigator. We measured 17 3D back parameters in each scan. We performed a multivariate analysis of variances to test the hypothesis of no difference for all variables, measured intra-rater and inter-investigator reliability with intra-class correlation (ICC) coefficients, and calculated mean values. RESULTS: There were highly reproducible ICC values between investigators for 6 parameters (ICC > 0.75), moderate ICC values for 8 parameters (0.75 > ICC > 0.4), and poor ICC values for 3 parameters (ICC < 0.4), all at p < .05. Intra-investigator ICCs were moderate to excellent for almost all parameters. CONCLUSIONS: The Milwaukee Topography System can be used to monitor and measure 3D back contours in children. The 3D back parameters values measured in the typically developing population can be considered baseline values that can be compared with parameters measured in children with idiopathic scoliosis.

Electromyography nerve conduction velocity evaluation of children with clubfeet.

Neurologic deficit has been implicated as a possible etiology for clubfoot and a cause for recurrent deformity in patients who have undergone clubfoot surgery. In the study reported here, we wanted to determine if clubfoot patients with peroneal weakness had any neurologic deficits on electromyography nerve conduction velocity (EMG-NCV) studies before surgery and if there was any association between neurologic deficit and clubfoot recurrence. We reviewed the EMG-NCV studies of 36 patients involving 57 cases of idiopathic clubfoot and recurrence of the deformity or muscle weakness. In the clubfoot patients with weak peroneal muscle and no prior surgical history, 45% of the studies were interpreted as normal, 20% as neuropathic, 15% as mixed myopathic and neuropathic, 10% as radicular, and 10% as myopathic. In the clubfoot patients with recurrence after clubfoot repair surgeries, 57% had abnormal EMG-NCV studies. Specifically, peroneal mononeuropathy was the most common disorder (41% of clubfoot patients treated surgically). Awareness of a significant incidence of neurologic deficit may help in preoperative planning by indicating that ultimately a tendon transfer may be necessary to obtain a plantigrade foot.

Upper limb function and brain reorganization after constraint-induced movement therapy in children with hemiplegia.

OBJECTIVE: The aims of this study were to (1) investigate the effectiveness of CIMT for children with hemiplegia, (2) determine the feasibility of using fMRI for describing brain activity patterns before and after CIMT and (3) describe changes in brain reorganization after CIMT in children with hemiplegia using fMRI. DESIGN: Before and after study with one group. METHODS: Ten children aged 7-14 years (M = 11.0, SD = 2.5) with hemiplegia received CIMT over a 2-week period using a before and after design. Clinical measures included the Melbourne Assessment of Unilateral Upper Limb Function, upper limb kinematics and parent questionnaire. Children were measured with fMRI before and after CIMT. RESULTS: Findings showed that CIMT may be effective at improving upper limb function in some, but not all children; those children with a moderate degree of impairment seemed to benefit the most. fMRI findings correlated moderately with clinical measures. CONCLUSION: Although unique challenges with fMRI data collection exist for this population, it provides potentially valuable information to better understand mechanisms of change after interventions such as CIMT.

Reliability of a functional classification system in the monitoring of patients with idiopathic scoliosis.

STUDY DESIGN: Patients with scoliosis from 1999 to 2001 were monitored using radiographs and the Quantec Spinal Imaging System (Quantec) to validate the Functional Classification System (FCS) developed at Children's Hospital of Wisconsin (CHW). OBJECTIVE: To determine the accuracy of the FCS. SUMMARY OF BACKGROUND DATA: The authors evaluated different noninvasive ways of evaluating the scoliotic spine. The FCS was developed as a means to predict the degree of scoliotic curve. METHODS: Consecutive scoliosis visits (543) seen at CHW between 1999 and 2001 for initial or follow-up examination were investigated; of them, 157 had an radiograph within 6 months of Quantec. Subjects were placed into groups based on Cobb Angles. FCS classifications were compared to Cobb angle groupings and calculated sensitivity and specificity. Pearson's correlation coefficient was calculated for 39 subjects. RESULTS: Sensitivity of the FCS for single curve groups ranged from 0.50 to 0.63 and specificity from 0.64 to 0.86. For double curve, both sensitivity and specificity ranged from 0.48 to 0.81. Pearson's correlation was statistically significant (r = 0.45, P < 0.05). CONCLUSIONS: Sensitivity, specificity, and Pearson's correlation coefficient reflect the reliability of the Quantec method. Therefore, the FCS can be considered as a reliable tool for monitoring the progression of scoliosis with reduced need of radiographs.

Increased blood loss during posterior spinal fusion for idiopathic scoliosis in an adolescent with Fontan physiology.

A 15-year-old patient with Fontan physiology experienced major blood loss during posterior spinal fusion for idiopathic scoliosis. Contributing factors for the increased blood loss and potentially useful measures to limit blood loss in patients with Fontan physiology are discussed.

Correlation of foot radiographs with foot function as analyzed by plantar pressure distribution.

The goal of this study was to correlate radiographic measurements to the dynamic plantar pressure of the residual clubfoot. This was done by comparing radiographs and EMED plantar pressure results in 61 idiopathic clubfeet in 39 children at an average of 8 years after complete subtalar release. Radiographic measures were obtained using the standard method outlined by Simons, and pressure data were collected for eight regions of the foot. Pearson correlation analysis was performed and the most significant correlation was found between the calcaneal/first metatarsal angle in the lateral radiographic view (r = 0.72) and the midfoot contact area. In the anteroposterior view there was mild correlation between the talus/first metatarsal angle and both the peak pressure and plantar contact area. The results of this study indicate that radiographs used in concert with dynamic plantar pressure analysis will provide a more complete assessment of the corrected clubfoot.