1.
Science
; 174(4016): 1341-3, 1971 Dec 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5135720
RESUMO
Creatine reacts with nitrite under acid conditions to produce first sarcosine and then N-nitrososarcosine, which is a weak carcinogen in the rat. Creatinine reacts with acidified nitrite to produce either creatinine-5-oxime or 1-methylhydantoin-5-oxime, depending on reaction conditions. The toxicity and environmental significance of these compounds is not yet known.