1.
J Med Primatol
; 51(5): 284-287, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36030392
RESUMO
Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross-species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4+ T cell decline and increases in plasma viral loads.