Detalhe da pesquisa
1.
Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.
Bioorg Med Chem Lett
; 24(7): 1790-4, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24618302
2.
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Bioorg Med Chem Lett
; 23(4): 985-8, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23317570
3.
Discovery of oral and inhaled PDE4 inhibitors.
Bioorg Med Chem Lett
; 23(20): 5528-32, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24018187
4.
Discovery of oxazole-based PDE4 inhibitors with picomolar potency.
Bioorg Med Chem Lett
; 22(7): 2594-7, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22401864
5.
Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.
Bioorg Med Chem Lett
; 22(14): 4896-9, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22687744
6.
The optimization of pyridazinone series of glucan synthase inhibitors.
Bioorg Med Chem Lett
; 22(16): 5268-71, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22818082
7.
Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
Antimicrob Agents Chemother
; 55(11): 5099-106, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21844320
8.
The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors.
Bioorg Med Chem Lett
; 21(6): 1819-22, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316223
9.
SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors.
Bioorg Med Chem Lett
; 21(10): 2890-3, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21489787
10.
The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(17): 5004-8, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20685118
11.
Structure and activity relationships of tartrate-based TACE inhibitors.
Bioorg Med Chem Lett
; 20(16): 4812-5, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20638281
12.
The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem Lett
; 20(3): 1189-93, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022498
13.
Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 5(10): 1082-7, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349648
14.
Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
ACS Med Chem Lett
; 4(8): 773-8, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900745
15.
Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration.
Eur J Pharmacol
; 643(2-3): 274-81, 2010 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20621091
16.
New agents to treat life-threatening fungal infections.
Curr Top Med Chem
; 8(7): 592-602, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18473885
17.
Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.
Bioorg Med Chem Lett
; 17(18): 5150-4, 2007 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17683932
18.
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 16(4): 989-94, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16297617
19.
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
Bioorg Med Chem Lett
; 15(12): 3020-3, 2005 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15908209
20.
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.
Bioorg Med Chem Lett
; 15(5): 1375-8, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713390