Detalhe da pesquisa
1.
Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis.
Hepatol Commun
; 6(9): 2298-2309, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35735253
2.
Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection.
Antiviral Res
; 203: 105329, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35525335
3.
Binding energy and catalysis by D-xylose isomerase: kinetic, product, and X-ray crystallographic analysis of enzyme-catalyzed isomerization of (R)-glyceraldehyde.
Biochemistry
; 50(46): 10170-81, 2011 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21995300
4.
Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.
Bioorg Med Chem Lett
; 21(18): 5206-9, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840217
5.
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
J Med Chem
; 64(8): 5001-5017, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33835812
6.
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Bioorg Med Chem Lett
; 20(15): 4607-10, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594845
7.
Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Bioorg Med Chem Lett
; 20(12): 3618-22, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20493695
8.
Scrambling of oxygen-18 during the "borderline" solvolysis of 1-(3-nitrophenyl)ethyl tosylate.
Org Lett
; 6(20): 3633-6, 2004 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15387566
9.
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
J Med Chem
; 57(4): 1454-72, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24456472
10.
Hydrolysis of the quinone methide of butylated hydroxytoluene in aqueous solutions.
J Pharm Sci
; 102(10): 3579-85, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23873381
11.
A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents.
PLoS One
; 7(10): e46300, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23056280
12.
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
J Med Chem
; 55(11): 4936-54, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524527
13.
Kinetics and mechanism of the hydrolytic degradation of indinavir: intramolecular catalysis.
J Pharm Sci
; 97(9): 3810-9, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18186489
14.
Structure-Reactivity Relationships for ß-Galactosidase (Escherichia coli, lac Z): A Second Derivative Effect on ß(nuc) for Addition of Alkyl Alcohols to an Oxocarbenium Ion Reaction Intermediate.
J Phys Org Chem
; 21(7-8): 531-537, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19684875
15.
The Generation and Reactions of Quinone Methides.
Adv Phys Org Chem
; 45: 39-91, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24511169
16.
Ground-state, transition-state, and metal-cation effects of the 2-hydroxyl group on beta-D-galactopyranosyl transfer catalyzed by beta-galactosidase (Escherichia coli, lac Z).
Biochemistry
; 44(35): 11872-81, 2005 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16128589
17.
Hydrogen bonding and catalysis of solvolysis of 4-methoxybenzyl fluoride.
J Am Chem Soc
; 124(33): 9798-805, 2002 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12175239
18.
Substituent effects on carbocation stability: the pK(R) for p-quinone methide.
J Am Chem Soc
; 125(29): 8814-9, 2003 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-12862476
19.
Kinetic and thermodynamic barriers to carbon and oxygen alkylation of phenol and phenoxide ion by the 1-(4-methoxyphenyl)ethyl carbocation.
J Am Chem Soc
; 125(50): 15455-65, 2003 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-14664591