Prospects of сomplex pharmaceutical composition application for pharmacological correction of metabolic syndrome.

Metabolic syndrome (MetS) is a symptomatic complex characterized by insulin resistance, impaired prooxidant-antioxidantbalance of the body with the development of subchronic inflammation, and dyslipidemia. The aim of the study is to investigate the effect of a complex pharmaceutical composition (CPC) (antioxidants and metabolitotropic agents), which is widely used in medical practice in Ukraine as a multivitamin complex, on experimental metabolic syndrome in rats. The effectof CPC on the correction of experimental MetS in rats, induced by a high content of carbohydrates and fats in the diet, was assessed. MetS in rats was characterized by a decrease in the sensitivity of cells to insulin, increased glucose content, and aviolation of its utilization, prooxidant-antioxidant disbalance. The results of the conducted studies indicate the positive effect of CPC, which contains ethyl esters of omega-3 acids, vitamin E, coenzyme Q10, zinc, vitamin A, biotin, and selenium, on the sensitivity of cells to insulin, glucose utilization, duration of hyperglycemia and indicators of free radical oxidation processes and antioxidant defense systems in rats with experimental MetS. These results prove the feasibility of using CPC to correct metabolic syndrome.

SUBSTANTIATION OF SUBSTITUTION THERAPY MEDICATION FOR DRY EYE SYNDROME TREATMENT IN PATIENTS USING CONTACT LENS VISION CORRECTION.

OBJECTIVE: The aim: To substantiate the selection of a substitution therapy medication for dry eye syndrome treatment in patients wearing different kinds of contact lenses. PATIENTS AND METHODS: Materials and methods: A structural analysis of the assortment of substitution therapy medications for dry eye syndrome treatment as well as a content analysis of the information given in the labelling claims of various substitution therapy medication was conducted. Than they were segmented using the criteria of whether the substitution therapy medications may be used in patients with dry eye syndrome who wear contact lenses. RESULTS: Results: The labelling claims of 82.36% substitution therapy medications registered in Ukraine assortment contain information on either full or partial compatibility with contact lenses. The use of 11.76% of the assortment is impossible for patients wearing soft contact lenses, while patients wearing hard contact lenses need to wait for some period of time (15-20 min) before putting contact lenses back on. CONCLUSION: Conclusions: The pharmaceutical market of Ukraine is characterized by a wide assortment of substitution therapy medications for dry eye syndrome treatment, which can be used in patients wearing contact lenses. Based on the data received, it has been determined that 70.59% of substitution therapy medications are compatible with contact lenses of all types and only the use of 8.82% of the substitution therapy medications assortment is contraindicated for dry eye syndrome treatment in patients wearing contact lenses.