Detalhe da pesquisa
1.
Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.
Chem Res Toxicol
; 33(1): 191-201, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31566356
2.
Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Bioorg Med Chem Lett
; 29(14): 1842-1848, 2019 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31109791
3.
Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.
Mol Pharm
; 14(5): 1634-1645, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329443
4.
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(21): 4945-4949, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25978966
5.
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(22): 5437-43, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318999
6.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
ACS Infect Dis
; 10(5): 1679-1695, 2024 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38581700
7.
Metabolic activation and major protein target of a 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonist.
Chem Res Toxicol
; 25(7): 1412-22, 2012 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22765480
8.
Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
Bioorg Med Chem Lett
; 21(18): 5547-51, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21784634
9.
Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.
Curr Opin Drug Discov Devel
; 11(1): 43-52, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18175266
10.
Comparative disposition and metabolism of paraherquamide in sheep, gerbils, and dogs.
Drug Metab Dispos
; 36(8): 1659-69, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18505789
11.
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorg Med Chem Lett
; 18(5): 1696-701, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18243692
12.
Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
ACS Med Chem Lett
; 9(7): 685-690, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034601
13.
Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6.
Curr Drug Metab
; 8(1): 59-77, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266524
14.
Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
ACS Med Chem Lett
; 8(2): 221-226, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197316
15.
2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.
J Med Chem
; 56(14): 5940-8, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23808489
16.
Pharmacokinetics of Cefovecin in squirrel monkey (Saimiri sciureus), rhesus macaques (Macaca mulatta), and cynomolgus macaques (Macaca fascicularis).
J Am Assoc Lab Anim Sci
; 49(6): 805-8, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21205444
17.
Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
J Med Chem
; 52(9): 3039-46, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19354254
18.
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Bioorg Med Chem Lett
; 17(22): 6172-7, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17889534
19.
Topological role of cytochrome P450 2D6 active site residues.
Arch Biochem Biophys
; 447(1): 53-8, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16466686
20.
Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
Drug Metab Dispos
; 34(8): 1367-75, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16698892