Detalhe da pesquisa
1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125593
2.
Novel pH Selective, Highly Lytic Peptides Based on a Chimeric Influenza Hemagglutinin Peptide/Cell Penetrating Peptide Motif.
Molecules
; 24(11)2019 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-31159194
3.
Rapid HATU-mediated solution phase siRNA conjugation.
Bioconjug Chem
; 22(8): 1723-8, 2011 Aug 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-21744777
4.
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
Eur J Med Chem
; 224: 113686, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34303079
5.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34704436
6.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 54(11): 4812-24, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20805392
7.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609585
8.
Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
J Med Chem
; 63(22): 13796-13824, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33170686
9.
Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 53(6): 2424-31, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289522
10.
The peptide hormone glucagon forms amyloid fibrils with two coexisting ß-strand conformations.
Nat Struct Mol Biol
; 26(7): 592-598, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235909
11.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18396399
12.
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Neuropharmacology
; 82: 161-73, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291536
13.
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
J Med Chem
; 51(20): 6503-11, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18826204
14.
Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Bioorg Med Chem Lett
; 16(5): 1146-50, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16368234
15.
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Bioorg Med Chem Lett
; 12(15): 2027-30, 2002 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12113834