Detalhe da pesquisa
1.
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
J Pharmacol Exp Ther
; 324(3): 894-901, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083913
2.
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis.
Mol Cancer Ther
; 4(8): 1198-204, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16093435
3.
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J Med Chem
; 48(26): 8163-73, 2005 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16366598
4.
Oral coadministration of ß-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation.
J Pharm Sci
; 101(7): 2545-56, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22473491
5.
JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia.
Mol Cancer Ther
; 8(11): 3151-61, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19887542
6.
Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).
Angiogenesis
; 7(2): 91-6, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15516829
7.
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives.
Bioorg Med Chem Lett
; 12(4): 589-91, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844678
8.
1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability.
Bioorg Med Chem Lett
; 14(23): 5937-41, 2004 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15501072
9.
A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.
Mol Pharmacol
; 66(3): 635-47, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15322256
10.
Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
Bioorg Med Chem Lett
; 14(20): 5227-32, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380233