Detalhe da pesquisa
1.
Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.
Curr Opin Infect Dis
; 37(3): 164-169, 2024 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38527455
2.
Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin.
Infect Immun
; 91(9): e0021323, 2023 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37607057
3.
Cholesterol-dependent cytolysins: The outstanding questions.
IUBMB Life
; 74(12): 1169-1179, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35836358
4.
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection.
J Immunol
; 204(1): 101-111, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776202
5.
The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria.
Annu Rev Microbiol
; 69: 323-40, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26488276
6.
Conformational changes during pore formation by the perforin-related protein pleurotolysin.
PLoS Biol
; 13(2): e1002049, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25654333
7.
An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin.
Proc Natl Acad Sci U S A
; 112(7): 2204-9, 2015 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25646411
8.
Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Proc Natl Acad Sci U S A
; 112(50): 15360-5, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26627714
9.
The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support ß-Barrel Pore Insertion.
J Biol Chem
; 290(29): 17733-17744, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26032415
10.
Mouse, but not human, ApoB-100 lipoprotein cholesterol is a potent innate inhibitor of Streptococcus pneumoniae pneumolysin.
PLoS Pathog
; 10(9): e1004353, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25188225
11.
Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel.
Nat Chem Biol
; 9(6): 383-9, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23563525
12.
Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein.
J Infect Dis
; 209(7): 1116-25, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24041791
13.
The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly.
PLoS Pathog
; 8(7): e1002787, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22792065
14.
Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Nat Commun
; 15(1): 5028, 2024 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38866748
15.
Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins.
J Biol Chem
; 287(29): 24534-43, 2012 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22645132
16.
Membrane assembly of the cholesterol-dependent cytolysin pore complex.
Biochim Biophys Acta
; 1818(4): 1028-38, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21835159
17.
Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria.
Infect Immun
; 81(1): 216-25, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23115036
18.
The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes.
PLoS Pathog
; 7(11): e1002356, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22072970
19.
Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface.
Proc Natl Acad Sci U S A
; 107(9): 4341-6, 2010 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20145114
20.
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
J Biol Chem
; 286(23): 20952-62, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507937