Detalhe da pesquisa
1.
Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Bioorg Med Chem Lett
; 30(9): 127066, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32173198
2.
Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Bioorg Med Chem Lett
; 26(23): 5724-5728, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815121
3.
Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons.
J Neurosci
; 33(5): 2048-59, 2013 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365242
4.
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment.
J Neurosci
; 33(16): 6950-63, 2013 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23595753
5.
Essential thalamic contribution to slow waves of natural sleep.
J Neurosci
; 33(50): 19599-610, 2013 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24336724
6.
Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2.
Mol Pharmacol
; 85(2): 218-25, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24214826
7.
Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.
J Neurosci
; 32(27): 9374-82, 2012 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22764245
8.
GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons.
J Neurosci
; 32(23): 7782-90, 2012 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22674255
9.
T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex.
J Neurosci
; 32(35): 12228-36, 2012 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22933804
10.
Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia.
Hum Psychopharmacol
; 28(2): 124-33, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23532746
11.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
ACS Med Chem Lett
; 14(8): 1088-1094, 2023 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37583812
12.
Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²âº channels and Ca²âº release from stores.
J Neurosci
; 31(38): 13546-61, 2011 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21940446
13.
Control of firing patterns through modulation of axon initial segment T-type calcium channels.
J Physiol
; 590(1): 109-18, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22063631
14.
Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Bioorg Med Chem Lett
; 27(5): 1333, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28169160
15.
State-dependent firing determines intrinsic dendritic Ca2+ signaling in thalamocortical neurons.
J Neurosci
; 30(44): 14843-53, 2010 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21048143
16.
Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.
J Neurosci
; 30(1): 99-109, 2010 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20053892
17.
Rebound excitation triggered by synaptic inhibition in cerebellar nuclear neurons is suppressed by selective T-type calcium channel block.
J Neurophysiol
; 106(5): 2653-61, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21849607
18.
Pharmacological validation of candidate causal sleep genes identified in an N2 cross.
J Neurogenet
; 25(4): 167-81, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22091728
19.
Pyridyl amides as potent inhibitors of T-type calcium channels.
Bioorg Med Chem Lett
; 21(6): 1692-6, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316226
20.
In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.
J Pharmacol Exp Ther
; 335(2): 409-17, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20682849