An enzyme immunoassay for determining albumin in human urine samples using an ultra-microanalytical system.

Microalbuminuria is a term to describe a moderate increase in the level of albumin in urine. It is an important prognostic marker for kidney damage in diseases such as diabetes mellitus and hypertension. A simple sandwich-type ultramicroELISA assay (UMELISA) has been developed for the measurement of albumin in human urine samples. Strips coated with a high affinity monoclonal antibody directed against albumin are used as solid phase, to ensure the specificity of the assay. The albumin assay was completed in 1 hr and 30 min, with a measuring range of 1.44-200 ng/mL. The intra- and inter-assay coefficients of variation were 3.98-4.35% and 7.59-8.92%, respectively, depending on the albumin concentrations evaluated. Percentage recovery ranged from 94.26 to 98.50%. Regression analysis showed a good correlation with the commercial quantitative turbidimetric test Microalbumin-turbilatex (n = 240, r = 0.994, p < .01). The analytical performance characteristics of our UMELISA MICROALBUMINA endorse its use for the quantification of albumin in human urine samples. This test will make a cost-effective diagnostic kit accessible to low-income countries such as Latin American countries and is now available in the Cuban Public Health System.

An enzyme immunoassay for determining epidermal growth factor (EGF) in human serum samples using an ultramicroanalytical system.

Human epidermal growth factor is a small peptide consisting of 53 amino acid residues, which stimulates cell proliferation and is associated with several human carcinomas. A simple sandwich-type ultramicroELISA assay (UMELISA), based on the advantages of high affinity reaction between streptavidin and biotin has been developed for the measurement of EGF in human serum samples. Strips coated with a high affinity monoclonal antibody directed against EGF are used as solid phase, to ensure the specificity of the assay. The EGF assay was completed in 18 hr, with a measuring range of 39-2500 pg/mL. The intra- and inter-assay coefficients of variation were 4.4-7.3% and 0-5.1%, respectively, depending on the EGF concentrations evaluated. Percentage recovery ranged from 96-104%. Regression analysis showed a good correlation with the commercially available Human EGF Immunoassay Quantikine® ELISA kit (n = 130, r = 0.92, P < 0.01). The analytical performance characteristics of our UMELISA EGF endorse its use for the quantification of EGF in human serum samples.

How "global" is research in early intervention for psychosis? A bibliometric analysis.

INTRODUCTION: Unlike high-income countries (HICs), there are few early intervention services for psychosis in low-and middle-income countries (LAMICs). In HICs, research spurred the growth of such services. Little is known about the state of EIP research in LAMICs, which we address by examining their research output and collaborations vis-à-vis that of HICs. METHODS: We conducted a search in Scopus database for early psychosis publications in scientific journals since 1980. Data from each record, including title, author affiliation, and date, were downloaded. For HIC-LAMIC collaborations, data on first, corresponding and last authors' affiliations, and funding were manually extracted. Descriptive statistics and social network analysis were conducted. RESULTS: Globally, early psychosis publications increased from 24 in 1980 to 1297 in 2022. Of 16,942 included publications, 16.1 % had LAMIC authors. 71.3 % involved authors from a single country (regardless of income level). 21.9 % were collaborations between HICs, 6.6 % between HICs and LAMICs, and 0.2 % among LAMICs. For research conducted in LAMICs and involving HIC-LAMIC collaborations, the first, last, and corresponding authors were LAMIC-based in 71.8 %, 60.7 %, and 63.0 %, respectively. These positions were dominated (80 %) by authors from four LAMICs. 29.4 % of the HIC-LAMIC subset was funded solely by LAMIC funders, predominantly two LAMICs. CONCLUSIONS: LAMICs are starkly underrepresented in the otherwise flourishing body of early psychosis research. They have far fewer collaborations and less funding than HICs. Closing these gaps in LAMICs where most of the world's youth live is imperative to generate the local knowledge needed to strengthen early psychosis services that are known to improve outcomes.

Pilot trial protocol: community intervention to improve depressive symptoms among Peruvian older adults.

BACKGROUND: Non-pharmacological interventions have proven effective at alleviating depression and anxiety symptoms in older adults. Methodological refinement and testing of these interventions in new contexts are needed on a small scale before their effectiveness and implementation can be evaluated. The purpose of this pilot study is to assess the feasibility of a future large-scale trial comparing an adapted mental health multi-component evidence-based intervention (VIDACTIVA) versus standard care for older adults experiencing depression symptoms in urban, resource-limited settings in Lima, Peru. Furthermore, this study will explore the acceptability, feasibility, and fidelity of implementing the intervention. METHODS: We will conduct an open-label, mixed methods pilot feasibility study with two parallel groups. A total of 64 older adults, stratified by sex, will be randomized at a 1:1 ratio to either the "intervention" or "control." Participants will be followed for 22 weeks after enrollment. Those in the intervention group will receive eight VIDACTIVA sessions administered by community health workers (CHWs) over 14 weeks, with an additional eight weeks of follow-up. Participants in the control group will receive two psychoeducation sessions from a study fieldworker and will be directed to health care centers. Standard care does not involve CHWs. We will evaluate screening rates, recruitment strategies, retention rates, the acceptability of randomization, and assessments. Additionally, we will assess preliminary implementation outcomes-acceptability, feasibility, and fidelity-from the perspectives of CHWs (interventionists), older adults (main participants), older adults' relatives, and healthcare professionals. DISCUSSION: If the findings from this feasibility trial are favorable, a fully powered randomized controlled trial will be conducted to evaluate `both the effectiveness and implementation of the intervention. This research will make a substantial contribution to the field of mental health in older adults, particularly by emphasizing a meticulous examination and documentation of the implementation process. By doing so, this study will offer valuable methodologies and metrics for adapting and assessing mental health interventions tailored to the unique needs of older adults in resource-constrained contexts and diverse cultural settings. TRIAL REGISTRATION: The current trial registration number is NCT06065020, which was registered on 26th September 2023.

Suicide news on Peruvian television channels: evaluation of compliance with WHO's reporting recommendations. / Noticias de suicidio en canales de televisión peruanos: evaluación del cumplimiento de las recomendaciones de la OMS para su notificación.

OBJECTIVE.: To determine if suicide news reports broadcasted by Peruvian television channels comply with the World Health Organization (WHO) recommendations for reporting suicide news. MATERIALS AND METHODS.: Quantitative and descriptive study. The unit of analysis was the suicide news broadcasted by eight Peruvian television channels during the years 2020 and 2021. News were classified into three categories: news about suicide, attempted suicide and suicide prevention. We used an evaluation instrument composed of WHO recommendations. RESULTS.: A total of 126 news reports were analyzed; but none of these complied fully with the WHO recommendations. The news reports on suicide or attempted suicide complied with 4 of 13 recommendations. Most reports complied with avoiding to publish suicide notes (97.4%); on the other hand, educating about suicide and its prevention, and not disseminating myths was the recommendation least complied with (0.9%). Suicide prevention news reports complied with 5 of 7 recommendations. CONCLUSIONS.: Suicide news reports on Peruvian television in 2020 and 2021 showed low compliance with WHO recommendations. Communication professionals have a fundamental role in suicide prevention, limiting sensitive information and disseminating helpful information. It is essential for communicators to be aware of these recommendations and for the journalism team and mental health professionals to work together in the communication of news related to suicide.

OBJETIVO.: Determinar el cumplimiento a las recomendaciones de la Organización Mundial de la Salud (OMS) de las noticias sobre suicidio emitidas por canales de la televisión peruana. MATERIALES Y MÉTODOS.: Estudio cuantitativo y descriptivo. La unidad de análisis fueron las noticias de suicidio emitidas por ocho canales de televisión peruana durante los años 2020 y 2021. Las noticias se clasificaron en tres categorías: noticias sobre suicidio, intento de suicidio y prevención del suicidio. Se utilizó un instrumento de evaluación compuesto por las recomendaciones de la OMS. RESULTADOS.: Se analizaron un total de 126 noticias. Ninguna de estas noticias cumplió en su totalidad con las recomendaciones de la OMS. Las noticias sobre suicidio o intento de suicidio cumplieron con 4 de 13 recomendaciones, siendo la recomendación más acatada la de evitar publicar notas suicidas (97,4%), mientras que la menos cumplida fue la de instruir a la población sobre el suicidio y su prevención, y no difundir mitos (0,9%). Las noticias de prevención de suicidio cumplieron 5 de 7 recomendaciones. CONCLUSIONES.: Las noticias sobre suicidio emitidas en la televisión peruana en los años 2020 y 2021 mostraron un bajo cumplimiento a las recomendaciones de la OMS. Los profesionales de la comunicación tienen un rol fundamental en la prevención del suicidio, limitando la información sensible y difundiendo información de ayuda. Es fundamental el conocimiento de estas recomendaciones por los comunicadores, y el trabajo conjunto entre el equipo periodístico y los profesionales de la salud mental en la comunicación de noticias relacionadas con el suicidio.

Validity, reliability and clinical utility of mental disorders: The case of ICD-11 schizophrenia.

Diagnostic classification systems categorise mental psychopathology in mental disorders. Although these entities are clinical constructs developed by consensus, it has been pointed out that in practice they are usually managed as natural entities and without evaluating aspects related to their nosological construction. The objectives of the study are to review a) the conceptualisation of mental disorders, b) the indicators of validity, reliability and clinical utility, and c) the values ​​of these indicators in ICD-11 schizophrenia. The results show that mental disorders are conceptualised as discrete entities, like the diseases of other areas of medicine; however, differences are observed between these diagnostic categories in clinical practice. The reliability and clinical utility of mental disorders are adequate; however, the validity is not yet clarified. Similarly, ICD-11 schizophrenia demonstrates adequate reliability and clinical utility, but its validity remains uncertain. The conceptualisation of psychopathology in discrete entities may be inadequate for its study, therefore dimensional and mixed models have been proposed. The indicators of validity, reliability and clinical utility enable us to obtain an accurate view of the nosological state of mental disorders when evaluating different aspects of their nosological construction.

Schizophrenia in ICD-11: Comparison of ICD-10 and DSM-5. / La esquizofrenia en la CIE-11: comparación con la CIE-10 y el DSM-5.

The conceptualization of schizophrenia has changed from its initial conception in the 19th century to the recent publication of the ICD-11. The changes incorporated in this latest version were made based on the evaluation of the current ICD, the available scientific evidence, and the consensus reached by its developers. In this paper we describe the conceptualization changes (diagnostic criteria and specifiers) of ICD-11 schizophrenia with respect to those of ICD-10 and DSM-5. The changes found are discussed based on the scientific literature published in Medline, Scopus and Scielo until July 2019 and the information on the Wordl Health Organization and American Psychiatric Association websites. Given that the diagnosis of schizophrenia is based on the diagnostic criteria of the diagnostic classification systems, it is important to know the changes made in its conceptualization and the evidence supporting such modifications.

Review of Early Intervention Programmes in Psychosis: Implementation Proposal for Peru. / Revisión de los programas de intervención temprana de psicosis: propuesta de implementación en Perú.

A delay in receiving an antipsychotic treatment is associated with unfavourable clinical and functional outcomes in patients with a first episode of psychosis. In recent years, early psychosis intervention programmes have been implemented that seek the early detection and treatment of patients who begin to describe psychotic symptoms. These programmes have shown to be more effective than standard care in improving the symptoms of the disorder and recovering the patient's functionality, in turn proving to be more cost-effective. The benefits of these programmes have led to their implementation in high-income countries. However, implementation in medium- and low-income countries has been slower. Peru, a Latin American country with an upper middle income, is undergoing a mental health reform that prioritises health care based on the prevention, treatment and psychosocial recovery of patients from a comprehensive and community approach. The present manuscript describes the characteristics and structure of the pioneering and more developed programmes for early psychosis intervention, and discusses the benefits and challenges of implementing an early psychosis intervention programme in Peru in the current context of mental health reform.

Validity, Reliability and Clinical Utility of Mental Disorders: The Case of ICD-11 Schizophrenia. / Validez, confiabilidad y utilidad clínica de los trastornos mentales: el caso de la esquizofrenia de la CIE-11.

Diagnostic classification systems categorise mental psychopathology in mental disorders. Although these entities are clinical constructs developed by consensus, it has been pointed out that in practice they are usually managed as natural entities and without evaluating aspects related to their nosological construction. The objectives of the study are to review a) the conceptualisation of mental disorders, b) the indicators of validity, reliability and clinical utility, and c) the values of these indicators in ICD-11 schizophrenia. The results show that mental disorders are conceptualised as discrete entities, like the diseases of other areas of medicine; however, differences are observed between these diagnostic categories in clinical practice. The reliability and clinical utility of mental disorders are adequate; however, the validity is not yet clarified. Similarly, ICD-11 schizophrenia demonstrates adequate reliability and clinical utility, but its validity remains uncertain. The conceptualisation of psychopathology in discrete entities may be inadequate for its study, therefore dimensional and mixed models have been proposed. The indicators of validity, reliability and clinical utility enable us to obtain an accurate view of the nosological state of mental disorders when evaluating different aspects of their nosological construction.

Cost variability of antipsychotics according to pharmaceutical establishments in Lima, Peru. / Variabilidad de costos de antipsicóticos según establecimientos farmacéuticos en Lima, Perú.

The objectives of the study were to determine the cost variability of antipsychotics in public (hospi tals) and private pharmaceutical establishments (pharmacies and clinics), calculate the cost variability of antipsychotics between establishments and estimate the cost of monthly maintenance treatment with antipsychotics. A cost analysis study was performed, unit costs of antipsychotics were obtained from the Peruvian Pharmaceutical Products Observatory. The results show that the cost variability of antipsycho tics was greater in pharmacies and clinics than in hospitals, and the analysis of cost variability between pharmaceutical establishments showed that the cost of an antipsychotic in a pharmacy and clinic was 1.3 to 140 times and 2.8 to 124 times, respectively, the cost of the drug in a hospital. The cost of monthly maintenance treatment varied from S/3 to S/2130 according to the drug and pharmaceutical establish ment.

Los objetivos del estudio fueron determinar la variabilidad de costos de antipsicóticos en establecimien tos farmacéuticos públicos (hospitales) y privados (farmacias y clínicas), calcular la variabilidad de cos tos de antipsicóticos entre establecimientos y estimar el costo de tratamiento mensual de mantenimiento con antipsicóticos. Se realizó un estudio de análisis de costos, los costos unitarios de los antipsicóticos se obtuvieron del Observatorio Peruano de Productos Farmacéuticos. Los resultados muestran que la va riabilidad de costos de los antipsicóticos fue mayor en farmacias y clínicas que en hospitales, y el análisis de variabilidad de costos entre establecimientos farmacéuticos mostró que el costo de un antipsicótico en una farmacia y clínica fue 1,3 a 140 veces y de 2,8 a 124 veces, respectivamente, el costo que tuvo el fármaco en un hospital. El costo de tratamiento mensual de mantenimiento varió de S/ 3 a S/ 2130 según el fármaco y establecimiento farmacéutico.

Self-disorders in Early Stages of the Schizophrenia Spectrum. / Alteraciones del Yo en las fases iniciales del espectro esquizofrénico.

The pathogenic nucleus of schizophrenia has varied according to the different eras and influences of distinguished clinical researchers. Self-disorders have also been recognised to be at the heart of this disorder, although they have seldom been studied due to their subjective nature. Recently, due to the growing interest in the study of the early stages of schizophrenia, the study of self-disorders has been resumed. The self-disorders in schizophrenia model, developed by Sass and Parnas, proposes that in this disorder the person suffers loss of the first-person perspective and experiences hyperreflexibility, diminished self-affection and disturbance of the field of awareness. Therefore, the person experiences feelings of strangeness about him/herself, difficulty in understanding the common sense of things and difficulty interacting with his/her environment. Based on this model, self-disorder evaluation instruments have been developed and empirical studies have been conducted to evaluate people at risk of developing a schizophrenia spectrum disorder. These studies show that self-disorders are found in prepsychotic stages and that their manifestation may predict the transition to schizophrenia spectrum disorders. These results have important clinical implications as they enable people in the early stages of the disorder to be identified and create the opportunity to apply early therapeutic interventions.

Intrafamilial and extrafamilial sexual assault and its association with alcohol consumption.

OBJECTIVE: Analyze the prevalence of intrafamilial and extrafamilial sexual assault in adolescents of Peru and its association with alcohol consumption. METHODS: We used a two-step and stratified probabilistic sampling to select male and female students in secondary education from all over Peru. The study included data from 54,756 students with information on demographics, alcohol and drug use, and sexual assault. The statistical analysis considered the complex sampling and we conducted two independent analyses by type of sexual assault (intrafamilial and extrafamilial), stratified by the sex of the victim. RESULTS: The prevalence of life of intrafamilial sexual assaults (5.4%, 95%CI 5.0-5.8) was similar to that of extrafamilial sexual assaults (6.1%, 95%CI 5.6-6.6). Alcohol consumption in the past year was associated with intrafamilial and extrafamilial sexual assaults that occurred in the same period after adjusting for confounders. Alcohol consumption in the past year was associated with non-physical and physical forms of intrafamilial and extrafamilial sexual assaults in the disaggregated analysis by type of assault. Alcohol consumption in the past year was associated with extrafamilial rape only among females (ORa = 2.8; 95%CI 1.3-5.9). CONCLUSIONS: Sexual assault against adolescent males and females by family members is a frequent form of victimization that is associated with alcohol consumption in Peru. It is important to examine this form of victimization among adolescents, especially those who consume alcohol.

Factores asociados con la agresión entre pares (Bullying): Resultados de un estudio poblacional en Perú / Factors associated with peer aggression (Bullying): Results of a population study in Peru

Introducción: La agresión entre pares (Bullying) es problema frecuente en la población de edad escolar, cuya ocurrencia se ve determinada por factores de distintos contextos, y no solo del escolar. Objetivo: Determinar la prevalencia anual de agresión entre pares en estudiantes de educación secundaria del Perú, en sus formas de agresión, victimización y agresión-victimización; y determinar los factores individuales, familiares y comunitarios asociados con la agresión entre pares en base al modelo ecológico de violencia. Material y métodos: Análisis secundario de la base de datos del "IV Estudio Nacional Prevención y Consumo de Drogas en estudiantes de secundaria 2012". Los datos de 48 025 estudiantes de educación secundaria fueron analizados tomando en cuenta el muestreo probabilístico bietápico y estratificado del estudio original. La variable dependiente agresión entre pares se estudió para cada uno de sus componentes: agresión, victimización y agresión-victimización. Resultados: El 48% de estudiantes reportó haber participado en actos de agresión entre pares en el periodo de un año (agresión: 10,5%, IC95%: 9,9-11,1; victimización: 15,8%, IC95%: 15,2-16,4; y agresión-victimización: 21,7%, IC95%: 20,6-22,9). Variables de las esferas individual y comunitaria se asociaron con la agresión, victimización y agresión-victimización. Conclusiones: La prevalencia de agresión entre pares en el Perú es elevada, siendo el grupo más frecuente el de agresión-victimización. Distintos factores individuales y comunitarios ejercen una influencia en la agresión entre pares. Los programas de intervención en agresión entre pares en el Perú deben tener un enfoque preventivo, multinivel y multidisciplinario que permita abordar todas las aristas del problema.

Background:Peer aggression (Bullying) is a frequent problem in the school-age population, whose occurrence is determined by factors from different contexts, and not only from the school. : To determine the annual Objectiveprevalence of peer aggression among secondary school students in Peru, in its formsofaggression,victimizationandaggression-victimization;andto determine the individual, family and community factors associated with peer aggressionbasedontheecologicalmodelofviolence.Materialand methods: Secondary analysis of the database of the "IV National Study on Drug Prevention and Consumption in High School Students 2012". Data from 48 025 secondary school students were analyzed taking into account the two-stage, stratified probability sampling of the original study. The dependent variable peeraggressionwasstudiedforeachofitscomponents:aggression, victimization and aggression-victimization. 48% of students reported Results:having participated in acts of peer aggression in the period of one year (aggression: 10.5%, 95%CI: 9.9-11.1; victimization: 15.8%, 95%CI: 15.2-16.4; and aggression-victimization: 21.7%, 95%CI: 20.6-22.9). Variables from the individual and community spheres were associated with aggression, victimization, and aggression-victimization. The prevalence of peer aggression in Peru is high, with the most frequent Conclusions: group being aggression-victimization. Different individual and community factors influence peer aggression. Intervention programs on peer aggression in Peru should have a preventive, multilevel and multidisciplinary approach to address all aspects of the problem.

Capacitación no escolarizada en psicoterapia: problemas y perspectivas / Non-school training in psychotherapy: problems and perspectives

Introducción: la capacitación no escolarizada en psicoterapia se define como la enseñanza de esta intervención por fuera de los entornos clínicos universitarios y de la normativa de educación universitaria. Aunque esta forma de estudios es bastante aceptada por psiquiatras y otros profesionales de la salud mental, esta podría no garantizar una adecuada capacitación y certificación. La presente revisión describe las características de la capacitación no escolarizada en psicoterapia en el Perú y aborda los potenciales problemas con la capacitación y certificación. Método: se realiza un análisis de la capacitación no escolarizada de psicoterapia y se la compara con el modelo formativo en psicoterapia de la residencia de Psiquiatría. Resultados: la capacitación no escolarizada en psicoterapia es una modalidad válida de estudios. Sin embargo, su alcance académico y profesional debe ser mejor valorado ya que estos programas podrían no contar con los recursos para reemplazar la capacitación universitaria, y no cuentan con el valor legal para facultar el ejercicio profesional de la psicoterapia de acuerdo a las normativas actuales de la educación universitaria y de licenciamiento profesional. Conclusión: es necesario fortalecer la capacitación de psicoterapia en la residencia de Psiquiatría y la apertura de programas universitarios de postgrado (programas de especialización, maestría o doctorado) para que la capacitación y certificación de psicoterapia sigan los canales formativos y de licenciamiento profesional oficiales.

Introduction: non-school training in psychotherapy is defined as the teaching of this intervention outside of university clinical settings and university education regulations. Although this form of study is widely accepted by psychiatrists and other mental health professionals, it may not guarantee adequate training and certification. This review describes the characteristics of non-school training in psychotherapy in Peru and addresses possible problems with training and certification. Method: an analysis of the non-schooled psychotherapy training is carried out and compared with the training model in psychotherapy of the psychiatric residency. Results: non-school training in psychotherapy is a valid study modality. However, their academic and professional scope should be better valued since these programs may not have the resources to replace university training, and they do not have the legal value to license the professional practice of psychotherapy according to current regulations of college education and professional licensing. Conclusion: it is necessary to strengthen psychotherapy training in psychiatry residency and the opening of postgraduate university programs (specialization, master or doctorate programs) so that psychotherapy training and certification follow the official training and professional licensing channels.

Validez, confiabilidad y utilidad clínica de los trastornos mentales: el caso de la esquizofrenia de la CIE-11 / Validity, Reliability and Clinical Utility of Mental Disorders: The Case of ICD-11 Schizophrenia

RESUMEN Los sistemas de clasificación diagnóstica categorizan la psicopatología en trastornos mentales. Aunque estas entidades son constructos clínicos elaborados por consenso, se ha señalado que en la práctica se suele tratarlas como entidades naturales y sin valorar aspectos relacionados con su construcción nosológica. Los objetivos del estudio son revisar: a) la conceptualización de los trastornos mentales; b) los indicadores de validez, confiabilidad y utilidad clínica, y c) los valores de estos indicadores en la esquizofrenia de la CIE-11. Los resultados muestran que los trastornos mentales están conceptualizados como entidades discretas, al igual que las enfermedades de otras áreas de la medicina; sin embargo, se observan diferencias entre ambas categorías diagnósticas en la práctica clínica. La confiabilidad y la utilidad clínica de los trastornos mentales son adecuadas; no obstante, la validez aún no está esclarecida. De modo similar, la esquizofrenia de la CIE-11 presenta adecuadas confiabilidad y utilidad clínica, pero su validez permanece incierta. La conceptualización de la psicopatología mental en entidades discretas puede resultar inadecuada para su estudio, por lo que se han propuesto modelos dimensionales y mixtos. Los indicadores de validez, confiabilidad y utilidad clínica permiten tener una visión precisa del estado nosológico de los trastornos mentales al valorar distintos aspectos de su construcción nosológica.

ABSTRACT Diagnostic classification systems categorize mental psychopathology in mental disorders. Although these entities are clinical constructs developed by consensus, it has been pointed out that in practice they are usually managed as natural entities and without evaluating aspects related to their nosological construction. The objectives of the study are to review a) the conceptualization of mental disorders, b) the indicators of validity, reliability and clinical utility, and c) the values of these indicators in ICD-11 schizophrenia. The results show that mental disorders are conceptualized as discrete entities, like the diseases of other areas of medicine; however, differences are observed between these diagnostic categories in clinical practice. The reliability and clinical utility of mental disorders are adequate; however, the validity is not yet clarified. Similarly, ICD-11 schizophrenia demonstrates adequate reliability and clinical utility, but its validity remains uncertain. The conceptualization of psychopathology in discrete entities may be inadequate for its study, therefore dimensional and mixed models have been proposed. The indicators of validity, reliability and clinical utility enable us to obtain an accurate view of the nosological state of mental disorders when evaluating different aspects of their nosological construction.

Publicación de noticias falsas durante la pandemia de COVID-19 en el Perú / Publication of fake news during the COVID-19 pandemic in Peru

El objetivo del estudio fue caracterizar las noticias identificadas como falsas por las instituciones del Poder Ejecutivo del Estado peruano, entre el 1o de febrero y el 4 de junio de 2020. Se revisaron las redes sociales Facebook y Twitter de la Presidencia de la República, del Consejo de Ministros y de los 18 ministerios. Se encontraron 72 noticias identificadas como falsas y el tipo más frecuente de falsificación fue la suplantación (51,4 por ciento). El 41,7 por ciento y 30,6 por ciento de las noticias falsas fueron de temas económicos y sociales respectivamente. El Ministerio de Desarrollo e Inclusión Social y el Ministerio de Educación fueron las instituciones más plagiadas y, a su vez, las que más desmintieron noticias falsas. En este escenario resulta necesario fortalecer los sistemas de detección y respuesta de noticias falsas de las instituciones del Estado, así como educar a la población en valorar la fuente de información que revisa en redes sociales(AU)

The objective of this study was to describe the news identified as false by the executive power of the Peruvian State from February 1 to June 4, 2020. This study reviewed the Facebook and Twitter social networks of the Presidency and Council of Ministers, and those of 18 ministries. Seventy-two news identified as false were found and the most frequent type of falsification was impersonation (51.4percent). 41.7percent and 30.6percent of fake news were about economic and social issues, respectively. The Ministry of Development and Social Inclusion and the Ministry of Education were the most plagiarized institutions, and consecutively, the ones that denied false news the most. In this scenario, it is necessary to strengthen the false news detection and response systems of state institutions, as well as to educate the population in valuing the source of information they review on social networks(AU)

Use of Bibliometric Analysis to Assess the Scientific Productivity and Impact of the Global Emerging Infections Surveillance and Response System Program, 2006-2012.

BACKGROUND: Scientific publication in academic literature is a key venue in which the U.S. Department of Defense's Global Emerging Infections Surveillance and Response System (GEIS) program disseminates infectious disease surveillance data. Bibliometric analyses are tools to evaluate scientific productivity and impact of published research, yet are not routinely used for disease surveillance. Our objective was to incorporate bibliometric indicators to measure scientific productivity and impact of GEIS-funded infectious disease surveillance, and assess their utility in the management of the GEIS surveillance program. METHODS: Metrics on GEIS program scientific publications, project funding, and countries of collaborating institutions from project years 2006 to 2012 were abstracted from annual reports and program databases and organized by the six surveillance priority focus areas: respiratory infections, gastrointestinal infections, febrile and vector-borne infections, antimicrobial resistance, sexually transmitted infections, and capacity building and outbreak response. Scientific productivity was defined as the number of scientific publications in peer-reviewed literature derived from GEIS-funded projects. Impact was defined as the number of citations of a GEIS-funded publication by other peer-reviewed publications, and the Thomson Reuters 2-year journal impact factor. Indicators were retrieved from the Web of Science and Journal Citation Report. To determine the global network of international collaborations between GEIS partners, countries were organized by the locations of collaborating institutions. RESULTS: Between 2006 and 2012, GEIS distributed approximately US $330 million to support 921 total projects. On average, GEIS funded 132 projects (range 96-160) with $47 million (range $43 million-$53 million), annually. The predominant surveillance focus areas were respiratory infections with 317 (34.4%) projects and $225 million, and febrile and vector-borne infections with 274 (29.8%) projects and $45 million. The number of annual respiratory infections-related projects peaked in 2006 and 2009. The number of febrile and vector-borne infections projects increased from 29 projects in 2006 to 58 in 2012. There were 651 articles published in 147 different peer-reviewed journals, with an average Thomson Reuters 2-year journal impact factor of 4.2 (range 0.3-53.5). On average, 93 articles were published per year (range 67-117) with $510,000 per publication. Febrile and vector-borne, respiratory, and gastrointestinal infections had 287, 167, and 73 articles published, respectively. Of the 651 articles published, 585 (89.9%) articles were cited at least once (range 1-1,045). Institutions from 90 countries located in all six World Health Organization regions collaborated with surveillance projects. CONCLUSIONS: These findings summarize the GEIS-funded surveillance portfolio between 2006 and 2012, and demonstrate the scientific productivity and impact of the program in each of the six disease surveillance priority focus areas. GEIS might benefit from further financial investment in both the febrile and vector-borne and sexually transmitted infections surveillance priority focus areas and increasing peer-reviewed publications of surveillance data derived from respiratory infections projects. Bibliometric indicators are useful to measure scientific productivity and impact in surveillance systems; and this methodology can be utilized as a management tool to assess future changes to GEIS surveillance priorities. Additional metrics should be developed when peer-reviewed literature is not used to disseminate noteworthy accomplishments.

[New rules for medical residency qualification in Peru: problems and perspectives]. / Nueva normativa de titulación en el residentado médico en el Perú: problemas y perspectivas.

On May 11, 2015, amendment RS 017-2015-SA to the Regulation of the National System of Medical Residency (RS 002-2006-SA) was published in the Peruvian official newspaper "El Peruano". This amendment establishes that the submission of a thesis or scholarly work is not necessary to obtain the title of medical specialist (article 28), but when a "work project" is performed in a specialty area, it must be presented at the conclusion of the second year of medical residency (article 27). This news has been welcomed by one sector of medical residents, while others believe that the measure conflicts with their training as specialists. This article aims to analyze the new rules for medical residency qualification in Peru and its implications for research developed during this formative stage for specialist physicians.

Aceptabilidad de la telepsiquiatría por psiquiatras en Lima durante la pandemia de COVID-19

Introducción. La pandemia de COVID-19 ha provocado la adopción de la telepsiquiatría para la atención médica psiquiátrica. Objetivo. Evaluar la aceptabilidad de la telepsiquiatría por médicos psiquiatras, determinar las características de la atención por telepsiquiatría y solicitar recomendaciones para la mejora del servicio de telepsiquiatría. Métodos. Se administró una encuesta virtual a psiquiatras de los tres principales hospitales psiquiátricos de Lima del 16 de junio al 16 de julio del 2020. Resultados. El 42,9% había trabajado en telepsiquiatría y el 57,2% percibía una alta congruencia (80%-100%) entre la telepsiquiatría y la atención presencial. La media global y en cada uno de los cinco dominios del índice de aceptabilidad estuvo por encima del promedio. La principal recomendación fue mejorar el flujo de atención. Conclusión. La telepsiquiatría es una modalidad de atención aceptada por psiquiatras. Se espera que este servicio mejore a medida que se identifiquen y resuelvan los problemas del trabajo diario.

Introduction. The COVID-19 pandemic has prompted the adoption of telepsychiatry for psychiatric medical care. Objective. To evaluate the acceptability of telepsychiatry by psychiatrists, determine the characteristics of telepsychiatric care and request recommendations for the improvement of the telepsychiatry service. Methods. A virtual survey was administered to psychiatrists of the three main psychiatric hospitals in Lima from June 16 to July 16, 2020. Results. 42.9% had worked in telepsychiatry and 57.2% perceived high congruence (80% -100%) between telepsychiatry and face-to-face care. The global mean and in each of the five domains of the acceptability index was above the average. The main recommendation was to improve the flow of care. Conclusion. Telepsychiatry is a modality of care accepted by psychiatrists, this service is expected to improve as problems of daily work are identified and resolved.

La esquizofrenia en la CIE-11: comparación con la CIE-10 y el DSM-5 / Schizophrenia in ICD-11: Comparison of ICD-10 and DSM-5

La conceptualización de la esquizofrenia ha cambiado desde su concepción inicial en el siglo XIX hasta la reciente publicación de la CIE-11. Los cambios incorporados en esta última versión se han realizado con base en la evaluación de la CIE vigente, la evidencia científica disponible y los consensos logrados por sus desarrolladores. En el presente trabajo se describen los cambios en la conceptualización (criterios diagnósticos y especificadores) de la esquizofrenia de la CIE-11 respecto a aquella de la CIE-10 y del DSM-5. Los cambios encontrados son discutidos con base en la bibliografía científica publicada en Medline, Scopus y Scielo hasta julio del 2019 y la información de las páginas web de la Organización Mundial de la Salud y la American Psychiatric Association. Dado que el diagnóstico de la esquizofrenia se basa en los criterios diagnósticos de los sistemas de clasificación diagnóstica, resulta importante conocer los cambios hechos en su conceptualización y la evidencia que sustenta tales modificaciones

The conceptualization of schizophrenia has changed from its initial conception in the 19th century to the recent publication of the ICD-11. The changes incorporated in this latest version were made based on the evaluation of the current ICD, the available scientific evidence, and the consensus reached by its developers. In this paper we describe the conceptualization changes (diagnostic criteria and specifiers) of ICD-11 schizophrenia with respect to those of ICD-10 and DSM-5. The changes found are discussed based on the scientific literature published in Medline, Scopus and Scielo until July 2019 and the information on the Wordl Health Organization and American Psychiatric Association websites. Given that the diagnosis of schizophrenia is based on the diagnostic criteria of the diagnostic classification systems, it is important to know the changes made in its conceptualization and the evidence supporting such modifications