Detalhe da pesquisa
1.
Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.
PLoS Pathog
; 19(5): e1011358, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37126530
2.
A CcdB toxin-derived peptide acts as a broad-spectrum antibacterial therapeutic in infected mice.
EMBO Rep
; 24(7): e55338, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37166011
3.
Mechanistic insights into global suppressors of protein folding defects.
PLoS Genet
; 18(8): e1010334, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36037221
4.
Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity, and neutralization sensitivity.
J Virol
; 97(11): e0092223, 2023 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37861334
5.
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein.
Nat Chem Biol
; 18(10): 1046-1055, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35654847
6.
Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries.
J Biol Chem
; 298(4): 101785, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247389
7.
Molecular bases for strong phenotypic effects of single synonymous codon substitutions in the E. coli ccdB toxin gene.
BMC Genomics
; 24(1): 732, 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049728
8.
The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality.
Mol Biol Evol
; 39(10)2022 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36069948
9.
A facile method of mapping HIV-1 neutralizing epitopes using chemically masked cysteines and deep sequencing.
Proc Natl Acad Sci U S A
; 117(47): 29584-29594, 2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33168755
10.
Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis.
J Bacteriol
; 204(4): e0005822, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35357163
11.
Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment.
J Biol Chem
; 296: 100025, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33154165
12.
Probing the Structure of the HIV-1 Envelope Trimer Using Aspartate Scanning Mutagenesis.
J Virol
; 94(21)2020 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32817217
13.
Bioinformatic and mutational studies of related toxin-antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues.
J Biol Chem
; 294(23): 9048-9063, 2019 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31018964
14.
CcdB at pH 4 Forms a Partially Unfolded State with a Dry Core.
Biophys J
; 116(5): 807-817, 2019 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30777307
15.
Molecular Determinants of Temperature-Sensitive Phenotypes.
Biochemistry
; 58(13): 1738-1750, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30843689
16.
Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.
J Biol Chem
; 293(39): 15002-15020, 2018 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30093409
17.
Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information.
Proteins
; 87(4): 326-336, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30615225
18.
A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques.
J Virol
; 92(5)2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29237847
19.
Rational elicitation of cold-sensitive phenotypes.
Proc Natl Acad Sci U S A
; 113(18): E2506-15, 2016 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27091994
20.
Isolation of an in Vitro Affinity-Matured, Thermostable "Headless" HA Stem Fragment That Binds Broadly Neutralizing Antibodies with High Affinity.
Biochemistry
; 57(26): 3817-3829, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29863853