Detalhe da pesquisa
1.
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.
J Autoimmun
; 144: 103181, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38522129
2.
New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function.
Ann Rheum Dis
; 82(11): 1415-1428, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37580108
3.
Interleukin-17 (IL-17) triggers systemic inflammation, peripheral vascular dysfunction, and related prothrombotic state in a mouse model of Alzheimer's disease.
Pharmacol Res
; 187: 106595, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36470548
4.
Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2'-Deoxyguanosine and 2'-Substituted RNA Analogues.
Int J Mol Sci
; 24(21)2023 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37958511
5.
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio.
Pharmacol Res
; 182: 106283, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35662629
6.
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Pharmacol Res
; 177: 106108, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121122
7.
Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives.
Nucleic Acids Res
; 48(22): 12556-12565, 2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270863
8.
Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads.
Int J Mol Sci
; 23(23)2022 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499249
9.
Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.
FASEB J
; 33(2): 2809-2822, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30303744
10.
Searching for novel hydrogen sulfide donors: The vascular effects of two thiourea derivatives.
Pharmacol Res
; 159: 105039, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32565313
11.
The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.
Bioorg Chem
; 76: 202-209, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29190476
12.
Backbone modified TBA analogues endowed with antiproliferative activity.
Biochim Biophys Acta Gen Subj
; 1861(5 Pt B): 1213-1221, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27663232
13.
Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.
Nucleic Acids Res
; 43(22): 10602-11, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26582916
14.
Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.
Nucleic Acids Res
; 43(16): 7702-16, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26250112
15.
Cystathionine ß-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.
Clin Sci (Lond)
; 130(1): 35-44, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26460077
16.
Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway.
Diabetes Obes Metab
; 18(12): 1236-1243, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27460695
17.
5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.
Chembiochem
; 15(16): 2427-34, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25214456
18.
CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway.
Front Pharmacol
; 14: 1090654, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36860295
19.
Biphasic inflammatory response induced by intra-plantar injection of L-cysteine: Role of CBS-derived H2S and S1P/NO signaling.
Biomed Pharmacother
; 167: 115536, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37742608
20.
Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway.
Redox Biol
; 62: 102657, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36913800