Detalhe da pesquisa
1.
Detecting bliss synergy in in vivo combination studies with a tumor kinetic model.
Pharm Stat
; 18(6): 688-699, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31140720
2.
Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products.
Cell Immunol
; 295(2): 118-26, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25880103
3.
Mechanistic understanding of translational pharmacokinetic-pharmacodynamic relationships in nonclinical tumor models: a case study of orally available novel inhibitors of anaplastic lymphoma kinase.
Drug Metab Dispos
; 43(1): 54-62, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349124
4.
Translational pharmacokinetic-pharmacodynamic modeling for an orally available novel inhibitor of anaplastic lymphoma kinase and c-Ros oncogene 1.
J Pharmacol Exp Ther
; 351(1): 67-76, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25073473
5.
A review of quantitative modeling of B cell responses to antigenic challenge.
J Pharmacokinet Pharmacodyn
; 41(5): 445-59, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25326873
6.
Characterisation of cotadutide's dual GLP-1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology model.
Br J Pharmacol
; 181(12): 1874-1885, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38403793
7.
Application of target-mediated drug disposition model to small molecule heat shock protein 90 inhibitors.
Drug Metab Dispos
; 41(6): 1285-94, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23557746
8.
Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models.
J Pharmacol Exp Ther
; 340(3): 549-57, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22129595
9.
The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics.
Br J Clin Pharmacol
; 74(6): 932-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22452385
10.
A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP-1 dual agonist.
CPT Pharmacometrics Syst Pharmacol
; 11(3): 302-317, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34889083
11.
Step-by-step comparison of ordinary differential equation and agent-based approaches to pharmacokinetic-pharmacodynamic models.
CPT Pharmacometrics Syst Pharmacol
; 11(2): 133-148, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34399036
12.
Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available heat shock protein 90 inhibitor in a human tumor xenograft mouse model.
J Pharmacol Exp Ther
; 338(3): 964-73, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21680888
13.
Ketorolac tromethamine: stereo-specific pharmacokinetics and single-dose use in postoperative infants aged 2-6 months.
Paediatr Anaesth
; 21(3): 325-34, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21199130
14.
Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total.
Pharmaceutics
; 13(4)2021 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918602
15.
IVGTT glucose minimal model covariate selection by nonlinear mixed-effects approach.
Am J Physiol Endocrinol Metab
; 298(5): E950-60, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20103736
16.
Measurement of human surfactant protein-B turnover in vivo from tracheal aspirates using targeted proteomics.
Anal Chem
; 82(6): 2561-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20178338
17.
Cellular signaling identifiability analysis: a case study.
J Theor Biol
; 264(2): 528-37, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20188743
18.
Opportunities for Quantitative Translational Modeling in Oncology.
Clin Pharmacol Ther
; 108(3): 447-457, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32569424
19.
Pharmacogenomic trial design: use of a PK/PD model to explore warfarin dosing interventions through clinical trial simulation.
Pharmacogenet Genomics
; 19(12): 965-71, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19881396
20.
Effects of cranberry juice on pharmacokinetics of beta-lactam antibiotics following oral administration.
Antimicrob Agents Chemother
; 53(7): 2725-32, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19398645