Detalhe da pesquisa
1.
Discovery of Orally Bioavailable and Liver-Targeted Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PHD) Inhibitors for the Treatment of Anemia.
ACS Med Chem Lett
; 9(12): 1193-1198, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613325
2.
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
J Med Chem
; 58(4): 1929-39, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625541
3.
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes.
J Med Chem
; 55(13): 6137-48, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22708876
4.
Characterization of two cyclic metabolites of sitagliptin.
Drug Metab Dispos
; 35(4): 521-4, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17220240
5.
Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans.
Drug Metab Dispos
; 35(4): 533-8, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17220239
6.
Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.
Drug Metab Dispos
; 35(4): 525-32, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17220241
7.
Species differences in metabolism and pharmacokinetics of a sphingosine-1-phosphate receptor agonist in rats and dogs: formation of a unique glutathione adduct in the rat.
Drug Metab Dispos
; 34(8): 1367-75, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16698892
8.
Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans.
Drug Metab Dispos
; 34(9): 1457-61, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16772365
9.
Species differences in the elimination of a peroxisome proliferator-activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide.
Drug Metab Dispos
; 33(12): 1894-904, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16183782
10.
Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Chem Res Toxicol
; 18(5): 880-8, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15892582
11.
Simultaneous determination of MK-0767 and seven metabolites in rat urine using liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 18(18): 2113-20, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317046
12.
Induction of hepatic phase II drug-metabolizing enzymes by 1,7-phenanthroline in rats is accompanied by induction of MRP3.
Drug Metab Dispos
; 31(6): 773-5, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12756211
13.
Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats.
Drug Metab Dispos
; 32(9): 909-14, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15319330
14.
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases.
Drug Metab Dispos
; 32(9): 1015-22, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15319344
15.
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.
Drug Metab Dispos
; 32(9): 1023-31, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15319345
16.
Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.
Drug Metab Dispos
; 32(10): 1154-61, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15229171
17.
Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(22): 3329-32, 2002 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12392744
18.
2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain.
Bioorg Med Chem Lett
; 12(5): 827-32, 2002 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-11859012