Detalhe da pesquisa
1.
Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.
Cancer Res
; 49(9): 2351-5, 1989 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2706623
2.
Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.
Cancer Res
; 53(8): 1853-61, 1993 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-8467505
3.
Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
Cancer Res
; 50(15): 4692-7, 1990 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2114946
4.
DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
Eur J Cancer
; 28A(10): 1597-600, 1992.
Artigo
em Inglês
| MEDLINE | ID: mdl-1389472
5.
Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069.
Int J Radiat Oncol Biol Phys
; 10(8): 1307-10, 1984 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-6547936
6.
The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
Int J Radiat Oncol Biol Phys
; 22(4): 643-7, 1992.
Artigo
em Inglês
| MEDLINE | ID: mdl-1544831
7.
Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
Int J Radiat Oncol Biol Phys
; 16(4): 983-6, 1989 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-2703406
8.
Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
Int J Radiat Oncol Biol Phys
; 22(4): 649-53, 1992.
Artigo
em Inglês
| MEDLINE | ID: mdl-1544832
9.
Pilot study of nimorazole as a hypoxic-cell sensitizer with the "chart" regimen in head and neck cancer.
Int J Radiat Oncol Biol Phys
; 42(4): 807-10, 1998 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-9845101
10.
A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.
Int J Radiat Oncol Biol Phys
; 10(9): 1755-8, 1984 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-6480458
11.
A phase I study of the combination of benznidazole and CCNU in man.
Int J Radiat Oncol Biol Phys
; 10(9): 1745-8, 1984 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-6480457
12.
Nitroimidazole bioreductive metabolism. Quantitation and characterisation of mouse tissue benznidazole nitroreductases in vivo and in vitro.
Biochem Pharmacol
; 36(6): 887-96, 1987 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-3105539
13.
Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
Biochem Pharmacol
; 39(11): 1735-42, 1990 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-2344370
14.
Heat-stimulated nitroreductive bioactivation of the 2-nitroimidazole benznidazole in vitro.
Biochem Pharmacol
; 36(16): 2627-32, 1987 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-3606661
15.
The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
Biochem Pharmacol
; 44(2): 251-9, 1992 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-1642640
16.
Drug metabolism and chemosensitization. Nitroimidazoles as inhibitors of drug metabolism.
Biochem Pharmacol
; 32(5): 857-64, 1983 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-6838633
17.
Pharmacokinetics and metabolism of the mixed-function hypoxic cell sensitizer prototype RSU 1069 in mice.
Cancer Chemother Pharmacol
; 22(4): 275-81, 1988.
Artigo
em Inglês
| MEDLINE | ID: mdl-3168141
18.
Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction.
Cancer Chemother Pharmacol
; 24(3): 172-6, 1989.
Artigo
em Inglês
| MEDLINE | ID: mdl-2736708
19.
Preclinical pharmacology of 1069C85, a novel tubulin binder.
Cancer Chemother Pharmacol
; 35(2): 169-73, 1994.
Artigo
em Inglês
| MEDLINE | ID: mdl-7987996
20.
Preclinical pharmacology and antitumour activity of the novel sequence-selective DNA minor-groove cross-linking agent DSB-120.
Cancer Chemother Pharmacol
; 38(5): 431-8, 1996.
Artigo
em Inglês
| MEDLINE | ID: mdl-8765436