1.
Bioorg Med Chem Lett
; 18(17): 4798-801, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18701276
RESUMO
A series of highly functionalized 3-aroyl and 3-phenoxy-2-methyl-7-azaindoles have been identified, which are potent selective PPARgamma modulators (SPPARgammaMs). Addition of substituents at the 6-position of the 7-azaindoles improves in vitro potency and pharmacokinetics. 7-Azaindoles have significantly improved off-target profiles compared to the parent indole series.