RESUMO
OBJECTIVES: In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging. METHODS: Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis. RESULTS: The OBS demonstrated significant variability across various demographic and health-related factors. There was a clear negative correlation observed between the higher OBS quartiles and PhenoAgeAccel, which presented sex-specific. RESULTS: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia. CONCLUSIONS: A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.
Assuntos
Envelhecimento , Inquéritos Nutricionais , Fenótipo , Humanos , Feminino , Masculino , Estudos Transversais , Adulto , Pessoa de Meia-Idade , Estados Unidos/epidemiologia , Envelhecimento/fisiologia , Idoso , Adulto Jovem , Dieta/estatística & dados numéricos , Estresse Oxidativo , Comportamentos Relacionados com a SaúdeRESUMO
As an invisible "endocrine organ", gut microbiota is widely involved in the regulation of nervous system, endocrine system, circulatory system, and digestive system. It is also closely related to host health and the occurrence of many chronic diseases. Relevant literature shows that high temperature, low temperature, and high-altitude hypoxia may have negative effects on commensal microorganisms. The stimulation of exercise may aggravate this reaction, which is related to the occurrence of exercise-induced fever and gastrointestinal and respiratory diseases. The intervention of probiotics can alleviate the above problems to a certain extent. Therefore, this paper takes exercise in a special environment as the starting point, deeply analyses the intervention effect and potential mechanism of probiotics, and provides the theoretical basis and reference for follow-up research and application of probiotics in sports science.