Detalhe da pesquisa
1.
Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary.
Xenobiotica
; 43(2): 219-25; discussion 226-7, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22803803
2.
Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.
J Med Chem
; 62(10): 4884-4901, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013090
3.
Development of a high-throughput in vitro assay using a novel Caco-2/rat hepatocyte system for the prediction of oral plasma area under the concentration versus time curve (AUC) in rats.
J Pharmacol Toxicol Methods
; 53(3): 215-8, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16181794
4.
Rat PXR reporter-gene activity correlates with the induction of CYP3A in rat precision-cut liver slices.
Comb Chem High Throughput Screen
; 8(4): 341-6, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16101010
5.
Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.
J Pharmacol Toxicol Methods
; 52(2): 234-43, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16125621
6.
Whatever happened to cassette-dosing pharmacokinetics?
Drug Discov Today
; 9(15): 652-8, 2004 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15279848
7.
Development of a screening assay to measure the loss of antibacterial activity in the presence of proteins: its use in optimizing compound structure.
J Biomol Screen
; 8(5): 555-8, 2003 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-14567782
8.
Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches.
Comb Chem High Throughput Screen
; 5(1): 29-37, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11860337
9.
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
J Pharmacol Toxicol Methods
; 47(3): 143-51, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12628305
10.
Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 780(2): 451-7, 2002 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12401373
11.
Meeting report: metabolites in safety testing (MIST) symposium-safety assessment of human metabolites: what's REALLY necessary to ascertain exposure coverage in safety tests?
AAPS J
; 15(4): 970-3, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23821354
12.
The role of exploratory drug metabolism and pharmacokinetics in new drug research: case study-selection of a thrombin receptor antagonist for development.
Curr Pharm Des
; 15(19): 2262-9, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19601827
13.
Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers.
Biochem Pharmacol
; 76(5): 680-9, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18647599
14.
Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034.
Perspect Medicin Chem
; 1: 1-9, 2007 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19812732
15.
Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias.
Bioorg Med Chem Lett
; 17(1): 282-4, 2007 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17095219
16.
Insights from a three-dimensional model into ligand binding to constitutive active receptor.
Drug Metab Dispos
; 30(9): 951-6, 2002 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12167558
17.
Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes.
Drug Metab Dispos
; 30(12): 1446-54, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12433818
18.
Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones.
Antimicrob Agents Chemother
; 48(3): 961-9, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14982790
19.
Evaluation of a novel in vitro Caco-2 hepatocyte hybrid system for predicting in vivo oral bioavailability.
Drug Metab Dispos
; 32(9): 937-42, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15319334