Detalhe da pesquisa
1.
Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.
Malar J
; 14: 359, 2015 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26390866
2.
Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials.
Lancet
; 374(9700): 1533-42, 2009 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19765816
3.
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Malar J
; 8: 204, 2009 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709418
4.
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
Eur J Clin Pharmacol
; 65(10): 977-87, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19517101
5.
Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.
Antimicrob Agents Chemother
; 52(11): 3883-8, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18725445
6.
Beyond registration--measuring the public-health potential of new treatments for malaria in Africa.
Lancet Infect Dis
; 6(1): 46-52, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16377534
7.
Malaria chemotherapy.
Adv Parasitol
; 61: 47-76, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16735162
8.
Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
Trans R Soc Trop Med Hyg
; 99(5): 341-6, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15780340
9.
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Trends Parasitol
; 20(3): 109-12, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16676416
10.
Clinical status and implications of antimalarial drug resistance.
Microbes Infect
; 4(2): 157-64, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11880047
11.
Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa.
Antimicrob Agents Chemother
; 53(4): 1722; author reply 1722-3, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19299520
12.
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
J Med Chem
; 46(23): 4933-45, 2003 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-14584944
13.
The potential for interactions between antimalarial and antiretroviral drugs.
AIDS
; 19(10): 995-1005, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15958830
14.
Coping with malaria in the face of resistance.
Int J Infect Dis
; 6(4): 246-52, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12718816
15.
Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.
Am J Trop Med Hyg
; 81(6): 969-78, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19996424
16.
In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa.
J Infect Dis
; 199(11): 1575-82, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19405863
17.
Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.
Pharmacogenomics
; 10(9): 1423-31, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19761366
18.
Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.
PLoS One
; 4(8): e6682, 2009 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19690618
19.
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
J Med Chem
; 52(5): 1408-15, 2009 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19222165
20.
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
J Med Chem
; 52(7): 1828-44, 2009 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19284751