Stable organic polymer anode for high rate and fast charge sodium based dual-ion battery.

Considering the extensive resources, flexible structural designability, and abundant active sites, organic electrodes have been considered as the ideal sodium storage materials. However, organic materials generally face the limitations of unstable and dissolved characteristic, leading to a poor cyclic stability. In this work, we proposed a carbon nanotube (CNT) modified polyimide as the anode for sodium-based dual-ion battery (SDIB). The polyimide remains well the structure and morphology of monomer with a stable conjugated structure and high degree of crystallinity, effectively enhancing the electrochemical performance of the SDIBs. Also, the cooperation with CNT particularly improves the ion conductivity of the anode and advances the rate performance. Combined with an ionic liquid electrolyte, the constructed dual-ion battery exhibits excellent rate capability, high specific discharge capacity and stable cycling performance. It delivers a specific discharge capacity of 119.3 mA h g-1 at 0.2 C (1 C=100 mA g-1) and still has a specific discharge capacity of 82.3 mA h g-1 even after 1000 cycles at 10 C. Besides, the system displays a low self-discharge rate and stable fast charging performance, which is expected to be applied in the large-scale electrochemical energy storage devices and inspire the future development of SDIBs.

Bacterial heat shock protein: A new crosstalk between T lymphocyte and macrophage via JAK2/STAT1 pathway in bloodstream infection.

Bloodstream infection (BSI) refers to the infection of blood by pathogens. Severe immune response to BSI can lead to sepsis, a systemic infection leading to multiple organ dysfunction, coupled with drug resistance, mortality, and limited clinical treatment options. This work aims to further investigate the new interplay between bacterial exocrine regulatory protein and host immune cells in the context of highly drug-resistant malignant BSI. Whether interfering with related regulatory signaling pathways can reverse the inflammatory disorder of immune cells. In-depth analysis of single-cell sequencing results in Septic patients for potential immunodeficiency factors. Analysis of key proteins enriched by host cells and key pathways using proteomics. Cell models and animal models validate the pathological effects of DnaK on T cells, MAITs, macrophages, and osteoclasts. The blood of patients was analyzed for the immunosuppression of T cells and MAITs. We identified that S. maltophilia-DnaK was enriched in immunodeficient T cells. The activation of the JAK2/STAT1 axis initiated the exhaustion of T cells. Septic patients with Gram-negative bacterial infections exhibited deficiencies in MAITs, which correspond to IFN-γ. Cellular and animal experiments confirmed that DnaK could facilitate MAIT depletion and M1 polarization of macrophages. Additionally, Fludarabine mitigated M1 polarization of blood, liver, and spleen in mice. Interestingly, DnaK also repressed osteoclastogenesis of macrophages stimulated by RANKL. S.maltophilia-DnaK prompts the activation of the JAK2/STAT1 axis in T cells and the M1 polarization of macrophages. Targeting the DnaK's crosstalk can be a potentially effective approach for treating the inflammatory disorder in the broad-spectrum drug-resistant BSI.

A Review of Anode Materials for Dual-Ion Batteries.

Distinct from "rocking-chair" lithium-ion batteries (LIBs), the unique anionic intercalation chemistry on the cathode side of dual-ion batteries (DIBs) endows them with intrinsic advantages of low cost, high voltage, and eco-friendly, which is attracting widespread attention, and is expected to achieve the next generation of large-scale energy storage applications. Although the electrochemical reactions on the anode side of DIBs are similar to that of LIBs, in fact, to match the rapid insertion kinetics of anions on the cathode side and consider the compatibility with electrolyte system which also serves as an active material, the anode materials play a very important role, and there is an urgent demand for rational structural design and performance optimization. A review and summarization of previous studies will facilitate the exploration and optimization of DIBs in the future. Here, we summarize the development process and working mechanism of DIBs and exhaustively categorize the latest research of DIBs anode materials and their applications in different battery systems. Moreover, the structural design, reaction mechanism and electrochemical performance of anode materials are briefly discussed. Finally, the fundamental challenges, potential strategies and perspectives are also put forward. It is hoped that this review could shed some light for researchers to explore more superior anode materials and advanced systems to further promote the development of DIBs.