1.
Angew Chem Int Ed Engl
; 61(47): e202209494, 2022 11 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36200408
RESUMO
A sequential phosphine-catalyzed asymmetric [3+2] annulation of aldimines with allenoates and oxidative central-to-axial chirality transfer strategy has been developed. This approach is operationally simple, allowing for rapid access to a range of axially chiral CF3 -containing 2-arylpyrroles with high enantiomeric excess. Furthermore, an atroposelective synthesis of esaxerenone is presented, illustrating the practical potential of the reported method.