Detalhe da pesquisa
1.
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes.
Bioorg Med Chem Lett
; 30(17): 127390, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32738973
2.
Discovery of novel BTK inhibitors with carboxylic acids.
Bioorg Med Chem Lett
; 27(6): 1471-1477, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254166
3.
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
Bioorg Med Chem Lett
; 27(16): 3939-3943, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28720503
4.
Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
J Biol Chem
; 286(8): 6433-48, 2011 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21118801
5.
Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening.
J Biol Chem
; 285(24): 18838-46, 2010 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385558
6.
Identification of Potent Reverse Indazole Inhibitors for HPK1.
ACS Med Chem Lett
; 12(3): 459-466, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738073
7.
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
ACS Med Chem Lett
; 12(4): 653-661, 2021 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33859804
8.
Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
SLAS Discov
; 26(1): 88-99, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32844715
9.
Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function.
PLoS One
; 15(12): e0243145, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270695
10.
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).
ACS Med Chem Lett
; 11(9): 1688-1693, 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32944135
11.
Functional antagonism of IL-1alpha induced gene expression profiles define the cAMP/PKA pathway as a unique regulator of IL-1alpha signaling networks.
J Recept Signal Transduct Res
; 29(5): 246-56, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19627252
12.
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
ACS Med Chem Lett
; 7(2): 198-203, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985298
13.
Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
J Biomol Screen
; 21(6): 608-19, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26969322
14.
Identification of direct target engagement biomarkers for kinase-targeted therapeutics.
PLoS One
; 6(10): e26459, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22039492
15.
Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.
Comb Chem High Throughput Screen
; 13(1): 16-26, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20214573
16.
Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.
J Biomol Screen
; 14(10): 1257-62, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19822882