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1.
Anal Chem ; 95(25): 9646-9653, 2023 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-37311071

RESUMO

Fluorescent rotors with aggregation-induced emission (AIE) and organelle-targeting properties have attracted great attention for sensing subcellular viscosity changes, which could help understand the relationships of abnormal fluctuations with many associated diseases. Despite the numerous efforts spent, it remains rare and urgent to explore the dual-organelle targeting probes and their structural relationships with viscosity-responsive and AIE properties. Therefore, in this work, we reported four meso-five-membered heterocycle-substituted BODIPY-based fluorescent probes, explored their viscosity-responsive and AIE properties, and further investigated their subcellular localization and viscosity-sensing applications in living cells. Interestingly, the meso-thiazole probe 1 showed both good viscosity-responsive and AIE (in pure water) properties and could successfully target both mitochondria and lysosomes, further imaging cellular viscosity changes by treating lipopolysaccharide and nystatin, attributing to the free rotation and potential dual-organelle targeting ability of the meso-thiazole group. The meso-benzothiophene probe 3 with a saturated sulfur only showed good viscosity-responsive properties in living cells with the aggregation-caused quenching effect and no subcellular localization. The meso-imidazole probe 2 showed the AIE phenomenon without an obvious viscosity-responsive property with a C═N bond, while the meso-benzopyrrole probe 4 displayed fluorescence quenching in polar solvents. Therefore, for the first time, we investigated the structure-property relationships of four meso-five-membered heterocycle-substituted BODIPY-based fluorescent rotors with viscosity-responsive and AIE properties, and among these, 1 with a C═N bond and a saturated sulfur on the meso-thiazole, potentially contributing to their corresponding AIE and viscosity-responsive properties, served as a sensitive AIE fluorescent rotor for imaging dual-organelle viscosity in both mitochondria and lysosomes.


Assuntos
Corantes Fluorescentes , Organelas , Corantes Fluorescentes/química , Viscosidade , Diagnóstico por Imagem
2.
J Phys Condens Matter ; 36(3)2023 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-37774718

RESUMO

We construct an islamic lattice by considering the nearest-neighbor (NN) hoppings with staggered magnetic fluxes and the next-NN hoppings. This model supports abundant quantum phases for various values of filling fractions. At1/4filling, Chern insulator (CI) phases with Chern numbersC=±1, -2and a zero-Chern-number topological insulator (ZCNTI) phase exist. At3/8filling, several CI phases with Chern numbersC=±1, 3and the ZCNTI phase are obtained. For the filling fraction 3/4, CI phases with Chern numbersC=±1, 2and two ZCNTI phase areas appear. Interestingly, these ZCNTI phases host both robust corner states and gapless edge states which can be characterized by the quantized polarization and quadrupole moment. We further find that staggered magnetic fluxes can give rise to the ZCNTI state at1/4and3/4fillings. Phase diagrams for filling fractions1/8,1/2,5/8and7/8are presented as well. In addition, flat bands are obtained for various filling fractions by tuning the hopping parameters. At 1/8 filling, a best topological flat band (TFB) with flatness ratio about 12 appears. Several trivial flat bands but with total Chern number|C|=1emerge in this model and exactly flat band is found at 3/8 filling. We further investigateν=1/2fractional Chern insulate state when hard-core bosons fill into this TFB model.

3.
Chem Commun (Camb) ; 58(12): 1930-1933, 2022 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-35040863

RESUMO

Two novel meso-CF3 BODIPY-based fluorescent rotors have been rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence "turn-on" effect, attributed to the special restricted rotation of meso-CF3 group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibits good mitochondrial localization and AIE property.


Assuntos
Compostos de Boro/química , Corantes Fluorescentes/química , Mitocôndrias/metabolismo , Viscosidade , Cátions , Células HeLa , Humanos , Estrutura Molecular , Espectrometria de Fluorescência
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