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BACKGROUND: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. METHODS: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. RESULTS: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and tuberculosis-related deaths, whereas there were significant and positive correlations between Nitrous oxide emissions in the energy sector (% of total) and tuberculosis-related deaths (p < 0.01). EKC analysis results showed that there is a U shaped between tuberculosis-related mortality and nitrous oxide emission levels in the world. DISCUSSION: Research results show that the relationship between nitrous oxide change and mortality is negative in the short term and positive in the long term. Therefore, although nitrous oxide gases cause respiratory diseases and mortality, it may be possible to transform a harmful environmental factor into a positive by developing devices or methods that will convert these gases into free radicals.
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Desenvolvimento Econômico , Tuberculose , Feminino , Masculino , Humanos , Óxido Nitroso , Dióxido de Carbono/análiseRESUMO
Genotyping by sequencing (GBS), which is a highly promising technique for molecular breeding, has been implemented in apricots, including Turkish, European, and Plum Pox Virus-resistant accessions. DNA samples were digested with the ApeKI restriction enzyme to construct a genome-complexity-reduced 90-plex GBS library. After filtering the raw sequences, approximately 28 G of clean data were generated, and 17,842 high-quality single-nucleotide polymorphism (SNP) loci were discovered. A total of 561 SNP loci with 0 or 1 missing reads for the 90 accessions produced 1162 markers that were used for the cluster and population structure analysis of the same collection. The results of the SNP analysis indicated that the relation of the European accessions with the western Turkish apricots was accurately positioned. The resistant accessions from different sources were clustered together, confirming the previous finding that SEO/Harlayne-type resistance probably originated from the same source. The Malatya accessions produce most of the world's dried apricots and are likely to be a genetically distinct group. Simple sequence repeat (SSR) and self-incompatibly (SI) locus characterization of the accessions was also included. SI genotyping supported the SNP findings, demonstrating both the reliability of SNP genotyping and the usefulness of SI genotyping for understanding the history of apricot breeding. The SSR genotyping revealed a characterization similar to that of SNP genotyping with a slightly lower resolution in the dendrogram. In conclusion, the GBS approach was validated in apricots, with the discovery of a large number of SNPs, and was demonstrated to be reliable by fingerprinting the accessions in a more informative manner.
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Técnicas de Genotipagem/métodos , Polimorfismo de Nucleotídeo Único , Prunus armeniaca/genética , Análise de Sequência de DNA/métodos , Análise por Conglomerados , DNA de Plantas/genética , Resistência à Doença , FilogeniaRESUMO
In this research, it was aimed to evaluate the effect of emergency department history on health literacy level and the role of digital literacy. A total of 454 participants were subjected to survey including health literacy scale, the digital literacy scale, and the demographic information form. Participants were divided into 2 groups as emergency medicine service (EMS) history (nâ =â 269) and no EMS history (nâ =â 185) groups. Health literacy, attitude, cognitive, and total digital literacy level of EMS history group were significantly higher than no EMS history group (Pâ <â .05). Social dimension of digital literacy scale was significantly higher in no EMS history group (Pâ <â .05). In no EMS history group, health literacy was significantly correlated with attitude (râ =â 0.298; Pâ <â .01), technical (râ =â 0.157; Pâ <â .01), cognitive (râ =â 0.369; Pâ <â .01), social (râ =â -0.302; Pâ <â .01) dimensions, and total score of digital literacy (râ =â 0.213; Pâ <â .01). In EMS history group, health literacy was significantly correlated with attitude (râ =â 0.553; Pâ <â .01), technical (râ =â 0.488; Pâ <â .01), cognitive (râ =â 0.555; Pâ <â .01) dimensions, and total score of digital literacy (râ =â 0.514; Pâ <â .01). Digital literacy had significant and positive effect on health literacy for all participants (ORâ =â 0.126; Pâ <â .01), no EMS history (ORâ =â 0.059; Pâ <â .01) and EMS history group (ORâ =â 0.191; Pâ <â .01). People's health literacy skills are positively impacted if they have ever received medical attention from EMS units, regardless of the reason. Furthermore, among those who have used emergency medical services in the past, the impact of digital literacy on health literacy is statistically substantially larger.
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Serviço Hospitalar de Emergência , Letramento em Saúde , Humanos , Letramento em Saúde/estatística & dados numéricos , Feminino , Masculino , Serviço Hospitalar de Emergência/estatística & dados numéricos , Adulto , Pessoa de Meia-Idade , Alfabetização Digital , Inquéritos e Questionários , IdosoRESUMO
This research aimed to examine the effectiveness of artificial intelligence applications in asthma and chronic obstructive pulmonary disease (COPD) outpatient treatment support in terms of patient health and public costs. The data obtained in the research using semiotic analysis, content analysis and trend analysis methods were analyzed with strengths, weakness, opportunities, threats (SWOT) analysis. In this context, 18 studies related to asthma, COPD and artificial intelligence were evaluated. The strengths of artificial intelligence applications in asthma and COPD outpatient treatment stand out as early diagnosis, access to more patients and reduced costs. The points that stand out among the weaknesses are the acceptance and use of technology and vulnerabilities related to artificial intelligence. Opportunities arise in developing differential diagnoses of asthma and COPD and in examining prognoses for the diseases more effectively. Malicious use, commercial data leaks and data security issues stand out among the threats. Although artificial intelligence applications provide great convenience in the outpatient treatment process for asthma and COPD diseases, precautions must be taken on a global scale and with the participation of international organizations against weaknesses and threats. In addition, there is an urgent need for accreditation for the practices to be carried out in this regard.
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Inteligência Artificial , Asma , Doença Pulmonar Obstrutiva Crônica , Humanos , Doença Pulmonar Obstrutiva Crônica/terapia , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doença Pulmonar Obstrutiva Crônica/economia , Asma/terapia , Asma/economia , Assistência Ambulatorial/economia , Assistência Ambulatorial/métodosRESUMO
Fryns syndrome cases with variable characteristics require careful preoperative evaluation and have challenges for airway management. Craniofacial anomalies can complicate both ventilation and intubation. Extubation can also be problematic because of limited pulmonary reserves.
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Primary pulmonary artery sarcoma is an uncommon neoplasm. Given its clinical and radiographic resemblance to pulmonary embolism, initial diagnostic steps may be complicated, leading to delay in diagnosis. This report presents the case of a 52-year-old-woman who was admitted with pulmonary embolism. She underwent pulmonary embolectomy, and histopathologic examination revealed synovial sarcoma.
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Neoplasias Pulmonares , Neoplasias de Tecido Vascular , Embolia Pulmonar , Sarcoma Sinovial , Sarcoma , Feminino , Humanos , Pessoa de Meia-Idade , Artéria Pulmonar/diagnóstico por imagem , Artéria Pulmonar/cirurgia , Artéria Pulmonar/patologia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/cirurgia , Sarcoma/cirurgia , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/etiologia , Embolia Pulmonar/cirurgia , Embolectomia/efeitos adversos , Neoplasias de Tecido Vascular/cirurgia , Neoplasias Pulmonares/patologiaRESUMO
The genus Crataegus is well distributed in Turkey as a wild plant, with numerous, inherently variable species and genotypes. RAPD markers were used to study 17 hawthorn genotypes belonging to Crataegus monogyna ssp. monogyna Jacq (2 genotypes), C. monogyna ssp. azarella Jacq (1), Crataegus pontica K.Koch (3), Crataegus orientalis var. orientalis Pallas Ex Bieb (3), Crataegus pseudoheterophylla Pojark (1), Crataegus aronia var. dentata Browicz (1), C. aronia var. aronia Browicz (4), and Crateagus x bornmuelleri Zabel (2). The 10 RAPD primers produced 72 polymorphic bands (88% polymorphism). A dendrogram based on Jaccard's index included four major groups and one outgroup according to taxa. The lowest genetic variability was observed within C. aronia var. aronia genotypes. The study demonstrated that RAPD analysis is efficient for genotyping wild-grown hawthorns.
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Crataegus/classificação , Crataegus/genética , Filogenia , Impressões Digitais de DNA , Meio Ambiente , Genótipo , Polimorfismo Genético , Técnica de Amplificação ao Acaso de DNA PolimórficoRESUMO
BACKGROUND: Metastasis is the leading cause of cancer deaths. Migration of tumor cells is an important stage in metastasis. Therefore, recent studies have focused on clarifying migration and migration-dependent cell functions such as angiogenesis, wound healing, and invasion. OBJECTIVES: In the present study, we aimed to investigate the effect of acetazolamide, which is a classical carbonic anhydrase inhibitor, on the cell viability, migration, and colony forming capacity of human LS174T colorectal cancer cells. METHODS: Three different cell culture techniques (MTT test, wound healing and clonogenic assay) were performed in this in vitro study on colorectal cancer cells. RESULTS: Acetazolamide reduced the cell viability, migration and colony formation ability of cells depending on dose. There was no significant difference between the cells treated with acetazolamide with 1 µM dose and the control. However, it can be concluded that acetazolamide exerts its effect on human colorectal cancer cells at 10-1000 µM concentrations. CONCLUSION: Acetazolamide was observed to significantly inhibit the cell viability, colony forming capacity, and migration ability in the culture medium of LS174T cells. This inhibitor effect of acetazolamide was observed to be dependent on the concentration in medium.
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Acetazolamida/farmacologia , Inibidores da Anidrase Carbônica/farmacologia , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Neoplasias Colorretais/tratamento farmacológico , Acetazolamida/administração & dosagem , Inibidores da Anidrase Carbônica/administração & dosagem , Linhagem Celular Tumoral , Relação Dose-Resposta a Droga , HumanosRESUMO
Here, we report a case of a 51-year-old man with acute pericardial tamponade requiring emergency pericardiocentesis after he suffered from sore throat, headache, malaise, and sweats for two weeks. Serological analyses revealed increased mumps IgM and IgG indicating an acute mumps infection whereas other bacterial and viral infections were excluded. In addition, MRI revealed atypical swelling of the left submandibular gland. Whereas mumps has become a rare entity in children due to comprehensive vaccination regimens in western civilizations, our case highlights mumps as an important differential diagnosis also in adults, where the virus can induce life-threatening complications such as pericardial tamponade.
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Cardiac echinococcosis is a rare manifestation of cystic echinococcosis (CE) caused by the tapeworm Echinococcus granulosus Among all patients suffering from CE, only 0.5%-2% exhibit a cardiac involvement. In addition, during the past years the number of CE cases reported in Western Europe remained roughly unchanged. However, we postulate that cases of CE in Western Europe will increase due to a growing number of refugees coming from endemic areas such as Southern Europe, Eastern Europe and the Middle East. Importantly, although cardiac echinococcosis is rare the disease can lead to many clinical complications, for instance acute heart failure and life-threatening arrhythmias. With respect to the increasing relevance of cardiac echinococcosis in Western Europe and the danger of fulminant disease courses, here we review diagnosis strategies and treatment options of the disease. Diagnosis of cardiac echinococcosis requires a detailed evaluation of the patients' case history, specific laboratory analyses and radiological imaging methods. Ultrasound, MRI and CT are key imaging tools for diagnosis, therapy control, prognosis estimation and disease course control. For the therapy of cardiac echinococcosis, a combination of surgical removal and drug treatment should be applied to symptomatic as well as asymptomatic patients. The complete surgical removal of the cyst(s) is the major prognosis factor of the cardiac manifestation of CE.
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Anticestoides/uso terapêutico , Procedimentos Cirúrgicos Cardíacos , Equinococose/diagnóstico , Equinococose/terapia , Echinococcus granulosus/isolamento & purificação , Cardiopatias/diagnóstico , Cardiopatias/terapia , Animais , Terapia Combinada , Equinococose/epidemiologia , Equinococose/parasitologia , Cardiopatias/epidemiologia , Cardiopatias/parasitologia , Humanos , Resultado do TratamentoRESUMO
Salinity is a serious environmental problem. Growing of plants like tomato can be solution for coping with soil salinity. For this purpose, response of tomato to salinity has been tested in the early growth stages. Characteristics of germination (percentage and period; length and fresh-dry weight of radicle and hypcotyl) and seedling (length and fresh-dry weight of root, shoot and whole plant; leaf number and area based on Relative Growth Rate); Na+ and K+ content of leaf; K+/Na+ rate of leaf has been studied at the 0, 50, 100 and 150 mM NaCl levels. Thus, it determined that tomato can be indicator for agricultural cultivation at the salinity environments at the early growth stages.
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Agricultura , Cloreto de Sódio/toxicidade , Solo , Solanum lycopersicum/efeitos dos fármacos , Meio Ambiente , Germinação/efeitos dos fármacos , Solanum lycopersicum/crescimento & desenvolvimento , Folhas de Planta/efeitos dos fármacos , Folhas de Planta/crescimento & desenvolvimento , Raízes de Plantas/efeitos dos fármacos , Raízes de Plantas/crescimento & desenvolvimento , Brotos de Planta/efeitos dos fármacos , Brotos de Planta/crescimento & desenvolvimento , Potássio/química , Plântula/efeitos dos fármacosRESUMO
This study was carried out to determine the possible effects of the Afsin-Elbistan Coal Power Plant (AECPP) on the environment.. The soil and plant samples were collected, based on the dominant wind direction, which is from northeast to southwest and we defined the northeast part of the plant as the less contaminated direction (LCD) and the southwest part as the more contaminated direction (MCD). The results indicated that the AECPP created environmental problems and caused contaminations especially in the MCD. The results of the statistical analysis for the measured attributes between the LCD and the MCD showed that there were significant differences for pH, SO4(-2)-S, Ni and Pb. Significant correlations were found between the distance from the AECPP and some of the measured soil and plant parameters in the MCD. The concentrations of SO4(-2)-S, Ni and Pb decreased as the distance increased. The discharge water carries a potential risk for the aquatic life and soil health in the area. The honey quality was also affected negatively by fly ash and emission.
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Carvão Mineral , Meio Ambiente , Monitoramento Ambiental/estatística & dados numéricos , Plantas/química , Centrais Elétricas , Solo/análise , Poluentes Químicos da Água/análise , Carbono/análise , Cinza de Carvão , Mel/análise , Concentração de Íons de Hidrogênio , Metais Pesados/análise , Material Particulado , Sódio/análise , Enxofre/análise , TurquiaRESUMO
A young woman presented with severe heart failure symptoms 4 years after percutaneous device closure of an atrial septal defect (ASD). There was residual left-to-right shunting, and the device was obstructing the inferior caval vein and tricuspid valve flow. Intraoperatively, the ASD was shown to be an inferior sinus venosus defect, and reconstruction of the mitral valve and the posterior wall of the left atrium was required. This case emphasizes the importance of appropriate patient selection for interventional ASD closure and demonstrates that patients with less-than-optimal results should be referred for surgical correction early, before the device produces secondary damage to atrial structures and atrioventricular valves.
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Cateterismo Cardíaco/instrumentação , Procedimentos Cirúrgicos Cardíacos , Comunicação Interatrial/terapia , Dispositivo para Oclusão Septal , Cateterismo Cardíaco/efeitos adversos , Ecocardiografia Doppler em Cores , Ecocardiografia Transesofagiana , Feminino , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/etiologia , Comunicação Interatrial/fisiopatologia , Comunicação Interatrial/cirurgia , Hemodinâmica , Humanos , Seleção de Pacientes , Flebografia , Valor Preditivo dos Testes , Desenho de Prótese , Falha de Tratamento , Adulto JovemRESUMO
Percutaneous nephrolithotomy (PCNL) is one of the most common treatment options in the management of kidney stones in children. While colon perforation during PCNL is reported as a rare complication in adults, there are scarce data regarding colon perforation during pediatric PCNL. We report the successful management of colon perforation occurring during PCNL and of a renal stone in a 6-year-old child. Moreover, we describe the procedure to be followed for colon perforation in children.
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Colo/patologia , Perfuração Intestinal/etiologia , Nefrostomia Percutânea/efeitos adversos , Criança , Humanos , Perfuração Intestinal/diagnóstico por imagem , Rim/diagnóstico por imagem , Rim/patologia , Cálculos Renais/complicações , Cálculos Renais/diagnóstico por imagem , Cálculos Renais/cirurgia , Masculino , Cuidados Pré-Operatórios , Radiografia , Ureter/diagnóstico por imagem , Ureter/patologia , Bexiga Urinária/diagnóstico por imagem , Bexiga Urinária/patologiaRESUMO
A young man presented with a chronic abdominal dermal irritation 4 years after implantation of a left ventricular assist device (LVAD; Berlin heart excor). The LVAD was needed because of end-stage heart failure following a chronic parvovirus B19 Infection. The implantation of mechanical circulatory support systems (MCS) has nowadays become an accepted treatment modality for patients with end-stage heart failure. Recent literature shows several intestinal complications related to MCS, but no case presents the development of a small bowel fistula to the jejunum, transversal colon and stomach. We present a case of inaccurate placement of Berlin heart excor LVAD cannulas and its impact. This case emphasises the importance of correct placement of VAD cannulas to achieve an optimal long-term result. After surgical treatment the postoperative course was prolonged because of increasing peritonitis probably based on ongoing intraperitoneal chronic contamination with intestinal germs. The patient unfortunately deceased.
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Coração Auxiliar/efeitos adversos , Fístula Intestinal/etiologia , Intestino Delgado , Adulto , Evolução Fatal , Humanos , Fístula Intestinal/cirurgia , MasculinoRESUMO
INTRODUCTION: To describe a new alternative technique to overcome several disadvantages of previous techniques to repair idiopathic hydrocele. Idiopathic hydrocele, which causes scrotal enlargement and discomfort for patients, is an abnormal fluid collection between the parietal and visceral layers of tunica vaginalis of the testis. Surgical and sclerotherapy treatments have previously been used to treat this problem. TECHNICAL CONSIDERATIONS: Forty-five patients with hydrocele (aged 19 to 67 years) underwent an alternative procedure using a silicone catheter 15 to 20 cm in length in which holes had been made to enable flow of the hydrocele fluid from the parietal layer of the tunica vaginalis to the surrounding scrotal tissue. After an incision of approximately 5 mm on the scrotal wall with a scalpel knife, a cannula was pushed through the hydrocele sac with a gentle rotation until reaching the upper scrotal wall. A silicone catheter with holes was passed through the cannula to the point of the incision by way of the cannula. At the end, both tips of the catheter were sutured. During the procedure, the hydrocele fluid was emptied using an angiocatheter before the cannula was removed. CONCLUSIONS: The results of this study indicate that this procedure does not require dissection, incision, or manipulation of the scrotal contents during treatment. It also resulted in a low rate of recurrence during the 1 to 3 years of follow-up. Additionally, the procedure has minimal complications and requires a short time, only about 15 minutes.