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1.
Can J Anaesth ; 2024 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-38480633

RESUMO

PURPOSE: The difficult airway cart is essential for difficult airway management. Recognition of the importance of human factors in critical scenarios promoted the evolution of the difficult airway cart. Limitation to essential equipment, a structured layout, and proper labelling should be observed. We sought to redesign the difficult airway cart accordingly and analyze how perioperative professionals reacted to it. METHODS: We conducted a two-phase prospective qualitative improvement project involving a multidisciplinary team. In phase 1, we reconfigured our difficult airway cart, including developing icons for labelling the drawers and discussing the equipment content. In phase 2, we delivered a multidisciplinary educational program and pre- and postsession questionnaires were administered to the professionals involved and compared. RESULTS: Phase 1 of the project encompassed 21 participants. We presented the final layout and content of the difficult airway cart. In phase 2, 44 participants responded the presession questionnaires, and 30 participants answered the postsession questionnaires. The results showed that the new design and the implementation program increased the comfort level of professionals involved in a potential airway crisis (presession mean [standard deviation (SD)]: anesthesiologists, 8.0 [1.9]; anesthesia assistants/respiratory therapists [AAs/RTs], 9.3 [0.8]; operating room registered nurses [OR RNs], 6.3 [2.7]; P = 0.001; postsession: anesthesiologists, 8.5 [2.0]; AAs/RTs, 9.6 [0.5]; OR RN, 7.9 [2.0]; P = 0.10). Nevertheless, the improvement was only statistically significant among the OR RNs (presession mean [SD]: 6.3 [2.7]; postsession: 7.9 [2.0]; P = 0.01). Additionally, the program facilitated the recognition of the location of airway equipment in the airway cart (positive responses ranging from 97% to 100%). CONCLUSION: Our quality improvement project successfully designed and implemented a new visual-based difficult airway cart at our institution. We believe this report enables other institutions to reproduce our project.


RéSUMé: OBJECTIF: Le chariot d'intubation difficile est essentiel pour la prise en charge des voies aériennes difficiles. La reconnaissance de l'importance des facteurs humains dans les situations critiques a favorisé l'évolution du chariot d'intubation difficile. Il est crucial de se limiter à l'équipement essentiel tout en organisant les éléments de manière structurée et en les étiquetant adéquatement. Nous avons cherché à repenser le chariot d'intubation difficile en gardant ces éléments à l'esprit et à analyser la réaction des professionnel·les oeuvrant en périopératoire. MéTHODE: Nous avons réalisé un projet d'amélioration qualitative prospective en deux phases impliquant une équipe multidisciplinaire. Au cours de la phase 1, nous avons reconfiguré notre chariot d'intubation difficile, en développant notamment des icônes pour étiqueter les tiroirs et en discutant du contenu matériel. Au cours de la phase 2, nous avons mis en place un programme éducatif multidisciplinaire et des questionnaires ont été administrés aux professionnel·les concerné·es avant et après la session. RéSULTATS: La phase 1 du projet a réuni 21 participant·es. Nous avons présenté la disposition finale et le contenu du chariot d'intubation difficile. Au cours de la phase 2, 44 participant·es ont répondu aux questionnaires d'avant-session et 30 participant·es ont répondu aux questionnaires d'après-session. Les résultats ont montré que la nouvelle disposition avec icônes et le programme de mise en œuvre ont augmenté le niveau de confort des professionnel·les impliqué·es dans une situation critique potentielle impliquant les voies aériennes (moyenne avant la séance [écart type (ET)] : anesthésiologistes, 8,0 [1,9]; assistant·es en anesthésie/inhalothérapeutes, 9,3 [0,8]; personnel infirmier autorisé en salle d'opération (SOP), 6,3 [2,7]; P = 0,001; après la session : anesthésiologistes, 8,5 [2,0]; assistant·es en anesthésie/inhalothérapeutes, 9,6 [0,5]; personnel infirmier de SOP, 7,9 [2,0]; P = 0,10). Néanmoins, l'amélioration n'était statistiquement significative que chez le personnel infirmier autorisé de SOP (moyenne avant la session [ET] : 6,3 [2,7]; après la session : 7,9 [2,0]; P = 0,01). De plus, le programme a facilité la reconnaissance de l'emplacement de l'équipement pour les voies aériennes dans le chariot d'intubation (réponses positives allant de 97 % à 100 %). CONCLUSION: Dans le cadre de notre projet d'amélioration de la qualité, nous avons réussi à concevoir et mettre en œuvre un nouveau chariot d'intubation difficile avec icônes dans notre établissement. Nous pensons que ce compte rendu permettra à d'autres institutions de reproduire notre projet.

2.
Eur J Anaesthesiol ; 38(8): 831-838, 2021 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-33883459

RESUMO

BACKGROUND: Decision-making deficits in airway emergencies have led to adverse patient outcomes. A cognitive aid would assist clinicians through critical decision-making steps, preventing key action omission. OBJECTIVE: We aimed to investigate the effects of a visual airway cognitive aid on decision-making in a simulated airway emergency scenario. DESIGN: Randomised controlled study. SETTING: Single-institution, tertiary-level hospital in Toronto, Canada from September 2017 to March 2019. PARTICIPANTS: Teams consisting of a participant anaesthesia resident, nurse and respiratory therapist were randomised to intervention (N = 20 teams) and control groups (N = 20 teams). INTERVENTION: Participants in both groups received a 15-min didactic session on crisis resource management which included teamwork communication and the concepts of cognitive aids for the management of nonairway and airway critical events. Only participants in the intervention group were familiarised, oriented and instructed on a visual airway cognitive aid that was developed for this study. Within 1 to 4 weeks after the teaching session, teams were video-recorded managing a simulated 'cannot intubate-cannot oxygenate' scenario with the aid displayed in the simulation centre. MAIN OUTCOME MEASURES: Decision-making time to perform a front-of-neck access (FONA), airway checklist actions, teamwork performances and a postscenario questionnaire. RESULTS: Both groups performed similar key airway actions; however, the intervention group took a shorter decision-making time than the control group to perform a FONA after a last action [mean ± SD, 80.9 ±â€Š54.5 vs. 122.2 ±â€Š55.7 s; difference (95% CI) -41.2 (-76.5 to -6.0) s, P = 0.023]. Furthermore, the intervention group used the aid more than the control group (63.0 vs. 28.1%, P < 0.001). Total time of scenario completion, action checklist and teamwork performances scores were similar between groups. CONCLUSIONS: Prior exposure and teaching of a visual airway cognitive aid improved decision-making time to perform a FONA during a simulated airway emergency.


Assuntos
Anestesiologia , Emergências , Manuseio das Vias Aéreas , Canadá , Cognição , Humanos
3.
BMC Anesthesiol ; 20(1): 216, 2020 08 27.
Artigo em Inglês | MEDLINE | ID: mdl-32854626

RESUMO

BACKGROUND: Airway guidelines recommend an emergency surgical airway as a potential life-saving treatment in a "Can't Intubate, Can't Oxygenate" (CICO) situation. Surgical airways can be achieved either through a cricothyroidotomy or tracheostomy. The current literature has limited data regarding complications of cricothyroidotomy and tracheostomy in an emergency situation. The objective of this systematic review is to analyze complications following cricothyroidotomy and tracheostomy in airway emergencies. METHODS: This synthesis of literature was exempt from ethics approval. Eight databases were searched from inception to October 2018, using a comprehensive search strategy. Studies were included if they were randomized controlled trials or observational studies reporting complications following emergency surgical airway. Complications were classified as minor (evolving to spontaneous remission or not requiring intervention or not persisting chronically), major (requiring intervention or persisting chronically), early (from the start of the procedure up to 7 days) and late (beyond 7 days of the procedure). RESULTS: We retrieved 2659 references from our search criteria. Following the removal of duplicates, title and abstract review, 33 articles were selected for full-text reading. Twenty-one articles were finally included in the systematic review. We found no differences in minor, major or early complications between the two techniques. However, late complications were significantly more frequent in the tracheostomy group [OR (95% CI) 0.21 (0.20-0.22), p < 0.0001]. CONCLUSIONS: Our results demonstrate that cricothyroidotomies performed in emergent situations resulted in fewer late complications than tracheostomies. This finding supports the recommendations from the latest Difficult Airway Society (DAS) guidelines regarding using cricothyroidotomy as the technique of choice for emergency surgical airway. However, emergency cricothyroidotomies should be converted to tracheostomies in a timely fashion as there is insufficient evidence to suggest that emergency cricothyrotomies are long term airways.


Assuntos
Manuseio das Vias Aéreas/efeitos adversos , Cartilagem Cricoide/cirurgia , Serviços Médicos de Emergência , Complicações Pós-Operatórias/etiologia , Tireoidectomia/efeitos adversos , Traqueostomia/efeitos adversos , Manuseio das Vias Aéreas/tendências , Serviços Médicos de Emergência/tendências , Humanos , Intubação Intratraqueal/efeitos adversos , Intubação Intratraqueal/tendências , Estudos Observacionais como Assunto/métodos , Complicações Pós-Operatórias/diagnóstico , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Estudos Retrospectivos , Tireoidectomia/tendências , Traqueostomia/tendências
4.
9.
Prog Transplant ; 33(4): 328-334, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37964560

RESUMO

Introduction: Solid organ transplantation is a lifesaving intervention requiring extensive coordination and communication for timely and safe care. The COVID-19 pandemic posed unique challenges to the safety and management of solid organ transplantation. This descriptive qualitative study aimed to understand how hospital stakeholders were affected by and responded to the COVID-19 pandemic to contribute toward improved healthcare delivery responses and strategies during times of systemic strain on the healthcare system. Methods: One-hour-long semistructured interviews were performed in 3 cohorts: healthcare professionals (N = 6), administrative staff (N = 6), and recipients (N = 4). Interviews were analyzed using conventional thematic content analysis. Thematic saturation was reached within each cohort. Findings: Twelve codes and 6 major themes were identified including the Impact on Clinical Practice, Virtual Healthcare Delivery, Communication, Research, Education and Training, Mental Health and Future Pandemic Planning. Reflecting on these codes and major themes, 4 recommendations were developed (Anticipation and Preparation, Maximizing Existing Resources and Networks, Standardization and the Virtual Environment and Caring for the Staff) to guide transplant programs to optimize healthcare pathways while enhancing the best practices during future pandemics. Conclusion: Transplant programs will benefit from anticipation and preparation procedures using ramping-down strategies, resource planning, and interprofessional collaboration while maximizing existing resources and networks. In parallel, transplant programs should standardize virtual practices and platforms for clinical and educational purposes while maintaining an open culture of mental health discussion and integrating strategies to support staff's mental health.


Assuntos
COVID-19 , Transplante de Órgãos , Transplantes , Humanos , Pandemias , Escolaridade , Pesquisa Qualitativa
10.
Tex Heart Inst J ; 50(3)2023 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-37270296

RESUMO

BACKGROUND: This study assessed in-hospital outcomes of patients with chronic systolic, diastolic, or mixed heart failure (HF) undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). METHODS: The Nationwide Inpatient Sample database was used to identify patients with aortic stenosis and chronic HF who underwent TAVR or SAVR between 2012 and 2015. Propensity score matching and multivariate logistic regression were used to determine outcome risk. RESULTS: A cohort of 9,879 patients with systolic (27.2%), diastolic (52.2%), and mixed (20.6%) chronic HF were included. No statistically significant differences in hospital mortality were noted. Overall, patients with diastolic HF had the shortest hospital stays and lowest costs. Compared with patients with diastolic HF, the risk of acute myocardial infarction (TAVR odds ratio [OR], 1.95; 95% CI, 1.20-3.19; P = .008; SAVR OR, 1.38; 95% CI, 0.98-1.95; P = .067) and cardiogenic shock (TAVR OR, 2.15; 95% CI, 1.43-3.23; P < .001; SAVR OR, 1.89; 95% CI, 1.42-2.53; P ≤ .001) was higher in patients with systolic HF, whereas the risk of permanent pacemaker implantation (TAVR OR, 0.58; 95% CI, 0.45-0.76; P < .001; SAVR OR, 0.58; 95% CI, 0.40-0.84; P = .004) was lower following aortic valve procedures. In TAVR, the risk of acute deep vein thrombosis and kidney injury was higher, although not statistically significant, in patients with systolic HF than in those with diastolic HF. CONCLUSION: These outcomes suggest that chronic HF types do not incur statistically significant hospital mortality risk in patients undergoing TAVR or SAVR.


Assuntos
Estenose da Valva Aórtica , Insuficiência Cardíaca , Implante de Prótese de Valva Cardíaca , Substituição da Valva Aórtica Transcateter , Humanos , Valva Aórtica/cirurgia , Implante de Prótese de Valva Cardíaca/efeitos adversos , Implante de Prótese de Valva Cardíaca/métodos , Resultado do Tratamento , Fatores de Risco , Complicações Pós-Operatórias/epidemiologia , Substituição da Valva Aórtica Transcateter/métodos , Estenose da Valva Aórtica/complicações , Estenose da Valva Aórtica/diagnóstico , Estenose da Valva Aórtica/cirurgia , Doença Crônica , Insuficiência Cardíaca/etiologia , Mortalidade Hospitalar
11.
Can Med Educ J ; 13(5): 106-110, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36310894

RESUMO

Acknowledging the mental remodeling that a foreign physician goes through and attempting to mitigate the difficulties of this process is crucial to achieving better outcomes in education and patient care. Canada's Healthcare System offers Clinical Fellowship Programs that allow physicians specialists to obtain advanced expertise in a chosen subspecialty. In a Clinical Fellowship, Canadian Medical Graduates (CMGs) practice alongside International Medical Graduates (IMGs); however, there is evidence that they undergo different challenges in the learning experience. IMGs usually have a higher cognitive load during the adaptation period, which can be due to multiple factors, such as the transition to practice in a foreign country, language, level of supervision, teaching methods applied, feeling disconnected from home, and other competing needs fellows face outside of the clinical context. We propose strategies that may help mitigate the transition to practice process that IMGs undergo when starting a Canadian fellowship, such as Self-Efficacy Encouraging Approach, Thinking Framework Across Cultures, and Social Engagement and Wellbeing.


Les médecins étrangers sont confrontés à un processus de remodelage cognitif. La reconnaissance de cette adaptation est cruciale pour l'atteinte de meilleurs résultats sur le plan de la formation et sur celui des soins aux patients. Le système de santé canadien offre des programmes de fellowship (ou formation complémentaire) de type clinique qui permettent à des médecins spécialistes d'acquérir une expertise plus poussée dans la sur-spécialité de leur choix. Dans les fellowships de type clinique, les diplômés des facultés de médecine canadiennes (DMC) exercent aux côtés de diplômés issus de programme de médecine internationaux (DIM). Cependant, il a été démontré que ces derniers sont confrontés à des défis particuliers dans leur expérience d'apprentissage. Pendant la période d'adaptation, les DIM ont généralement une charge cognitive plus importante, qui peut être due à de multiples facteurs tels que la transition vers la pratique dans un pays étranger, la langue, le niveau de supervision, les méthodes d'enseignement appliquées, le fait de sentir éloigné de chez soi, mais également à des facteurs présents à l'extérieur du contexte clinique. Nous proposons des stratégies qui peuvent contribuer à atténuer les difficultés auxquelles sont confrontés les fellows DIM qui débutent un programme au Canada notamment une approche de soutien à l'auto-efficacité, la perspective transculturelle et l'interaction sociale et le bien-être.

12.
CJEM ; 24(8): 862-866, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36346398

RESUMO

PURPOSE: A large vertical incision is recommended when performing front-of-neck access in patients with impalpable neck landmarks during a cannot intubate-cannot oxygenate (CICO) scenario. We investigated the impact of ultrasonography on vertical incision size of a front-of-neck access on an ultrasound-compatible impalpable porcine larynx model. METHODS: Emergency medicine and anesthesia trainees were randomized to the Ultrasound (US, n = 21) and Non-Ultrasound (NUS, n = 21) groups. Within 1 week after a teaching session on airway ultrasound and Scalpel-Bougie-Tube (SBT) technique, participants were instructed to perform cricothyroidotomy on the model during a simulated cannot intubate-cannot oxygenate scenario. The primary outcome was a vertical size incision. Secondary outcomes were procedural completion time, horizontal size incision, tissue injury severity, and correct tube placement. RESULTS: The ultrasound group performed a significantly smaller vertical incision [median (IQR), 35.0 (15, 40) vs 65.0 (52, 100) mm (95% CI) - 30.0 (- 55.1, - 4.9), p = 0.02] and took longer total time to complete the procedure [median (IQR), 200.5 (126, 267) vs 93.5 (71.0, 167.5) secs (95% CI) 91.0 (3.73, 178.3), p = 0.04]. Tissue injury severity and correct tube placement were similar between groups. CONCLUSIONS: Ultrasound-guided identification of the cricothyroid membrane significantly reduced the recommended vertical incision size with similar success rates. However, there was an increased time when performing a Scalpel-Bougie-Tube cricothyroidotomy on an impalpable porcine larynx model by physicians in training. Ultrasonography should not be used in an emergency scenario of airway rescue. Its potential use to pre-mark the cricothyroid membrane should be considered in difficult airway management of impalpable neck.


RéSUMé: OBJECTIF: Il est recommandé de pratiquer une grande incision verticale lors de l'accès à l'avant du cou chez les patients dont les repères du cou sont impalpables, dans le cadre d'un scénario d'intubation impossible à oxygéner (CICO). Nous avons étudié l'impact de l'échographie sur la taille de l'incision verticale d'un accès à la face avant du cou sur un modèle de larynx porcin impalpable compatible avec l'échographie. MéTHODES: Des stagiaires en médecine d'urgence et en anesthésie ont été répartis de manière aléatoire entre les groupes "échographie" (US, n = 21) et "non-échographie" (NUS, n = 21). Une semaine après une session d'enseignement sur l'échographie des voies aériennes et la technique Scalpel-Bougie-Tube (SBT), les participants ont reçu l'instruction de réaliser une cricothyroïdotomie sur le modèle lors d'un scénario simulé d'impossibilité d'intubation et d'oxygénation. Le résultat primaire était une incision de taille verticale. Les résultats secondaires étaient le temps de réalisation de la procédure, la taille horizontale de l'incision, la gravité de la lésion tissulaire et le placement correct du tube. RéSULTATS: Le groupe échographie a réalisé une incision verticale significativement plus petite [médiane (IQR), 35,0 (15,40) vs 65,0 (52,100) mm (IC à 95 %) -30,0 (-55,1, -4,9), p = 0,02] et a pris un temps total plus long pour terminer la procédure [médiane (IQR), 200,5 (126, 267) vs 93,5 (71,0, 167,5) secondes (IC à 95 %) 91,0 (3,73, 178,3), p = 0,04]. La gravité des lésions tissulaires et le placement correct du tube étaient similaires entre les groupes. CONCLUSIONS: L'identification échoguidée de la membrane cricothyroïdienne a réduit de manière significative la taille de l'incision verticale recommandée avec des taux de réussite similaires. Cependant, il y avait une augmentation du temps lors de la réalisation d'une cricothyroïdotomie Scalpel-Bougie-Tube sur un modèle de larynx porcin impalpable par des médecins en formation. L'échographie ne doit pas être utilisée dans un scénario d'urgence de sauvetage des voies respiratoires. Son utilisation potentielle pour pré-marquer la membrane cricothyroïdienne devrait être envisagée dans la gestion des voies aériennes difficiles du cou impalpable.


Assuntos
Cartilagem Cricoide , Laringe , Humanos , Suínos , Animais , Cartilagem Cricoide/cirurgia , Manuseio das Vias Aéreas/métodos , Pescoço/cirurgia , Ultrassonografia , Intubação Intratraqueal/métodos
13.
J Crit Care ; 60: 161-168, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32836091

RESUMO

PURPOSE: Conventional palpation techniques for cricothyroid membrane (CTM) identification are inaccurate and unreliable. Ultrasound plays a multi-faceted role in airway management, however there is limited literature around its use for CTM identification prior to cricothyrotomies. This review sought to compare ultrasound to palpation in the general population, identify its indications in subjects with ill-defined neck anatomy, and determine its role in defining neck anatomy. METHODS: Two reviewers independently assessed titles, abstracts and full-text English articles through the Ovid Medline and EMBASE databases. Studies related to ultrasound for CTM assessment and/or cricothyrotomy in subjects older than 12 years were included. RESULTS: Fourteen studies were selected. Compared to palpation, ultrasound has greater accuracy, but longer CTM identification times in those with normal airway anatomy. Interestingly, ultrasound offers comparable times to palpation in patients with difficult airways. Ultrasound also helps define anatomical parameters in the neutral and extended neck positions thereby underscoring the importance of neck positioning during cricothyrotomies and confirming consensus-based incision recommendations set by the Difficult Airway Society. CONCLUSION: Ultrasound appears to be superior to palpation for CTM localization especially in those with difficult airway anatomy and objectively defines neck anatomy. Its pre-emptive use should be incorporated during difficult airway management.


Assuntos
Cartilagem Cricoide/diagnóstico por imagem , Tecido Elástico/diagnóstico por imagem , Pescoço/diagnóstico por imagem , Palpação/métodos , Cartilagem Tireóidea/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Manuseio das Vias Aéreas/métodos , Cadáver , Cartilagem Cricoide/anatomia & histologia , Cartilagem Cricoide/cirurgia , Confiabilidade dos Dados , Tecido Elástico/anatomia & histologia , Tecido Elástico/cirurgia , Feminino , Voluntários Saudáveis , Humanos , Intubação Intratraqueal/métodos , Masculino , Pessoa de Meia-Idade , Pescoço/anatomia & histologia , Cartilagem Tireóidea/anatomia & histologia , Cartilagem Tireóidea/cirurgia , Ultrassonografia/métodos , Adulto Jovem
14.
A A Pract ; 12(11): 444-446, 2019 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-30640278

RESUMO

Transnasal humidified rapid-insufflation ventilatory exchange is a recently described technique for safer management of difficult airways and a novel ventilation technique under anesthesia. Its full potential in patient safety and benefits are still being investigated. We describe the use of transnasal humidified rapid-insufflation ventilatory exchange for deep sedation during dental extractions in a patient with severe cystic fibrosis as a precondition for lung transplantation. Patient wanted to have the procedure under general anesthesia with intubation due to extreme anxiety. However, we advocated deep IV sedation with transnasal humidified rapid-insufflation ventilatory exchange. Oxygenation was maintained without airway obstruction and pulmonary complications during the entire procedure of 110 minutes.


Assuntos
Fibrose Cística/terapia , Sedação Profunda/métodos , Insuflação/métodos , Administração Intranasal , Adulto , Manuseio das Vias Aéreas , Feminino , Humanos , Transplante de Pulmão , Troca Gasosa Pulmonar , Extração Dentária
15.
Head Neck ; 39(4): 744-747, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28000305

RESUMO

BACKGROUND: Parotidectomy is usually performed while the patient is under general anesthesia, however, sedation with locoregional anesthesia could be an alternative. METHODS: Fifteen adult patients with parotid tumors of the superficial lobe were included in this study. Anesthetic procedure consisted of sedation associated with cervical plexus and auriculotemporal nerve block. Sedation was managed based on the bispectral index. RESULTS: Superficial parotidectomies were performed in 13 patients, and combined partial resections were performed in 2 patients. The mean operative time was 118.2 ± 16.4 minutes. Conversion to general anesthesia was necessary in only 1 patient. Ten surgeries were performed on an outpatient basis. Definitive facial paralysis occurred in 1 patient. All patients reported total satisfaction with the procedure. CONCLUSION: In selected cases, parotidectomy under sedation plus locoregional anesthesia is feasible and safe. The careful selection of patients and the close collaboration with an anesthesiologist is the key to a successful procedure. © 2016 Wiley Periodicals, Inc. Head Neck 39: 744-747, 2017.


Assuntos
Anestesia Local/métodos , Mapeamento Encefálico , Sedação Consciente/métodos , Glândula Parótida/cirurgia , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anestésicos Locais/administração & dosagem , Estudos de Coortes , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/métodos , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Segurança do Paciente/estatística & dados numéricos , Satisfação do Paciente/estatística & dados numéricos , Seleção de Pacientes , Medição de Risco , Resultado do Tratamento , Adulto Jovem
16.
Environ Toxicol Pharmacol ; 19(2): 283-9, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21783487

RESUMO

In this study, we described the local peripheral antinociceptive activity produced by diphenyl diselenide in the formalin test as compared to ebselen, an amply studied organoselenium compound. A second objective was to evaluate, the possible mechanisms underlying the antinociceptive effect caused by diphenyl diselenide. Administration of diphenyl diselenide or ebselen produced a significant antinociceptive local effect on the late phase (15-30min) of the formalin test. As well, diphenyl diselenide and ebselen injected in the contra lateral paw produced a significant decrease in licking time on the late phase (15-30min). The mechanisms underlying the analgesic action of diphenyl diselenide seem to be unlike the activation of opioid, dopaminergic D2, muscarinic cholinergic receptors or the interaction with α(1) and α(2) adrenoceptors. Furthermore, the effect of a 5-HT(3) receptor antagonist in abolishing the antinociception induced by diphenyl diselenide suggests the involvement of serotonergic pathways.

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