Detalhe da pesquisa
1.
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood
; 120(13): 2669-78, 2012 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22806893
2.
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.
Biochem Biophys Res Commun
; 439(4): 586-90, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24041688
3.
Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors.
Bioorg Med Chem
; 20(6): 1940-6, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22133902
4.
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
Bioorg Med Chem
; 19(16): 4935-52, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778063
5.
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J Am Chem Soc
; 130(50): 17075-84, 2008 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19012396
6.
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(16): 4521-4, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18662877
7.
Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.
Bioorg Med Chem
; 16(16): 7777-87, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18644730
8.
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
J Clin Invest
; 126(6): 2077-92, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27183387
9.
Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase.
Cancer Res
; 76(16): 4805-15, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27325652
10.
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.
JCI Insight
; 1(7)2016 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275015
11.
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
ACS Med Chem Lett
; 6(7): 782-6, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191366
12.
Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta.
Antioxid Redox Signal
; 20(14): 2130-40, 2014 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24180557
13.
Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice.
Oncotarget
; 5(15): 6130-41, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25026279
14.
Therapeutic potential of targeting the oncogenic SHP2 phosphatase.
J Med Chem
; 57(15): 6594-609, 2014 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25003231
15.
Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.
Chem Commun (Camb)
; 49(20): 2064-6, 2013 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23380872
16.
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
FEBS J
; 280(2): 731-50, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22816879
17.
A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.
ChemMedChem
; 8(6): 904-8, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23568546
18.
SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice.
Mol Cell Biol
; 32(14): 2653-63, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22566685
19.
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
J Med Chem
; 55(22): 9492-509, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23098137
20.
Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.
ChemMedChem
; 5(12): 2051-6, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20957718