Detalhe da pesquisa
1.
Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N-Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans.
J Pharmacol Exp Ther
; 379(2): 134-146, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34413198
2.
Amino acids are sensitive glucagon receptor-specific biomarkers for glucagon-like peptide-1 receptor/glucagon receptor dual agonists.
Diabetes Obes Metab
; 22(12): 2437-2450, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33463043
3.
Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.
Br J Clin Pharmacol
; 81(1): 137-47, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26302359
4.
Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.
Antimicrob Agents Chemother
; 58(11): 6675-84, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155592
5.
Tacrolimus placental transfer at delivery and neonatal exposure through breast milk.
Br J Clin Pharmacol
; 76(6): 988-96, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23528073
6.
Diversity in Clinical Pharmacology: A Call to Action.
Clin Pharmacol Ther
; 113(3): 483-485, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36710622
7.
The quest for balance between capturing data and model complexity: A quantitative clinical pharmacology approach applied to monoclonal antibodies.
CPT Pharmacometrics Syst Pharmacol
; 12(5): 639-655, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36752286
8.
A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.
Clin Transl Sci
; 16(8): 1431-1444, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37154518
9.
Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe
; 31(5): 751-765.e11, 2023 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098341
10.
Pharmacokinetics of tacrolimus during pregnancy.
Ther Drug Monit
; 34(6): 660-70, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23007747
11.
How resilient were we in 2021? Results of a LinkedIn Survey including biomedical and pharmaceutical professionals using the Benatti Resiliency Model.
Clin Transl Sci
; 15(10): 2355-2365, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35981318
12.
Changing the drug development and therapeutic paradigm with biologic drug combinations and bispecifics: How to choose between these two approaches?
Clin Transl Sci
; 15(9): 2096-2104, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35611545
13.
Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.
Eur J Med Chem
; 236: 114330, 2022 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436670
14.
Simultaneous measurement of plasma vitamin D(3) metabolites, including 4ß,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry.
Anal Biochem
; 418(1): 126-33, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21784054
15.
Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans.
Clin Pharmacol Ther
; 109(3): 716-727, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33002189
16.
A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model.
MAbs
; 12(1): 1813962, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32967523
17.
Toward Progress in Quantitative Translational Medicine: A Call to Action.
Clin Pharmacol Ther
; 107(1): 85-88, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31750932
18.
Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A.
MAbs
; 12(1): 1770018, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32544369
19.
A Long-Acting PYY3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates.
Cell Metab
; 29(4): 837-843.e5, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30773465
20.
Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.
MAbs
; 9(8): 1306-1316, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28898162