Detalhe da pesquisa
1.
Discovery and directed evolution of C-C bond formation enzymes for the biosynthesis of ß-hydroxy-α-amino acids and derivatives.
Crit Rev Biotechnol
; : 1-20, 2024 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38566472
2.
Semirational Engineering of a Thermostable Carbonyl Reductase for the Precision Synthesis of (2R,3R)-2-Methyl-2-benzyl-3-hydroxycyclopentanone and Its Analogues.
J Org Chem
; 88(16): 11905-11912, 2023 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37526991
3.
Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib.
Chembiochem
; 23(5): e202100589, 2022 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34951083
4.
Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.
Angew Chem Int Ed Engl
; 61(17): e202116344, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35166000
5.
Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of ß-Amino Acids.
Angew Chem Int Ed Engl
; 60(18): 10203-10210, 2021 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33624917
6.
Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination.
Angew Chem Int Ed Engl
; 60(16): 8717-8721, 2021 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33555620
7.
Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy.
Angew Chem Int Ed Engl
; 60(7): 3679-3684, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33141478
8.
2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem
; 21(20): 2950-2956, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32421914
9.
Highly Diastereoselective Synthesis of 2,2-Disubstituted Cyclopentane-1,3-diols via Stepwise Ketone Reduction Enabling Concise Chirality Construction.
J Org Chem
; 85(15): 9599-9606, 2020 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32668161
10.
Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols.
Biol Chem
; 400(3): 313-321, 2019 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30269104
11.
Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation.
Appl Environ Microbiol
; 85(18)2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31324634
12.
A Fungal P450 Enzyme from Thanatephorus cucumeris with Steroid Hydroxylation Capabilities.
Appl Environ Microbiol
; 84(13)2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29728383
13.
Characterization of new recombinant 3-ketosteroid-Δ1-dehydrogenases for the biotransformation of steroids.
Appl Microbiol Biotechnol
; 101(15): 6049-6060, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28634849
14.
Semi-rational engineering of cytochrome CYP153A from Marinobacter aquaeolei for improved ω-hydroxylation activity towards oleic acid.
Appl Microbiol Biotechnol
; 100(20): 8779-88, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234138
15.
Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.
Chembiochem
; 16(6): 924-9, 2015 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25754803
16.
Characterization of (R)-selective amine transaminases identified by in silico motif sequence blast.
Appl Microbiol Biotechnol
; 99(6): 2613-21, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25267157
17.
Synthesis of α,ß-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction.
Beilstein J Org Chem
; 11: 2245-51, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26664647
18.
Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum.
Chembiochem
; 15(2): 217-22, 2014 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24339368
19.
Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines.
Appl Microbiol Biotechnol
; 98(4): 1681-9, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23793344
20.
Engineering a hydroxysteroid dehydrogenase to improve its soluble expression for the asymmetric reduction of cortisone to 11ß-hydrocortisone.
Appl Microbiol Biotechnol
; 98(21): 8879-86, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25081557