Detalhe da pesquisa
1.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrob Agents Chemother
; 66(1): e0158421, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34694880
2.
Multiple-Dose Pharmacokinetics, Pharmacodynamics, and Safety of the Urotensin-II Receptor Antagonist Palosuran in Healthy Male Subjects.
Pharmacology
; 102(5-6): 339-346, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30384375
3.
Comorbidities and pharmacotherapies in patients with Gaucher disease type 1: The potential for drug-drug interactions.
Mol Genet Metab
; 117(2): 172-8, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26674302
4.
Investigation of mutual pharmacokinetic interactions between macitentan, a novel endothelin receptor antagonist, and sildenafil in healthy subjects.
Br J Clin Pharmacol
; 78(5): 1035-42, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24962473
5.
First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials.
Br J Clin Pharmacol
; 75(2): 524-37, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22759078
6.
Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis.
Eur J Clin Pharmacol
; 68(5): 533-41, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22101624
7.
Macitentan: entry-into-humans study with a new endothelin receptor antagonist.
Eur J Clin Pharmacol
; 67(10): 977-84, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21541781
8.
Pharmacokinetics, safety and tolerability of miglustat in the treatment of pediatric patients with GM2 gangliosidosis.
Mol Genet Metab
; 97(4): 284-91, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19447653
9.
Influence of liver cirrhosis on the pharmacokinetics, pharmacodynamics, and safety of tezosentan.
J Clin Pharmacol
; 49(4): 455-64, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318695
10.
Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase.
J Clin Pharmacol
; 47(10): 1277-82, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17720777
11.
Influence of ethnic origin and sex on the pharmacokinetics of clazosentan.
J Clin Pharmacol
; 47(11): 1374-80, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17906281
12.
Effect of gender on the tolerability, safety and pharmacokinetics of clazosentan following long-term infusion.
Clin Drug Investig
; 27(11): 797-802, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17914898
13.
Comparative investigation of the pharmacokinetics of bosentan in Caucasian and Japanese healthy subjects.
J Clin Pharmacol
; 45(1): 42-7, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15601804
14.
In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide.
Clin Pharmacol Ther
; 71(4): 253-62, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11956508
15.
Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension.
Clin Pharmacol Ther
; 73(4): 372-82, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12709727
16.
Clinical pharmacology of bosentan, a dual endothelin receptor antagonist.
Clin Pharmacokinet
; 43(15): 1089-115, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15568889
17.
Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin.
Clin Pharmacokinet
; 42(3): 293-301, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12603176
18.
Treatment of secondary pulmonary hypertension with bosentan and its pharmacokinetic monitoring in ESRD.
Am J Kidney Dis
; 43(5): 923-6, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15112184
19.
Influence of food intake and formulation on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist.
J Clin Pharmacol
; 42(3): 283-9, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11865964
20.
Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist.
J Clin Pharmacol
; 43(1): 15-22, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12520623