Trading off spatio-temporal properties in 3D high-speed fMRI using interleaved stack-of-spirals trajectories.

PURPOSE: Highly undersampled acquisitions have been proposed to push the limits of temporal resolution in functional MRI. This contribution is aimed at identifying parameter sets that let the user trade-off between ultra-high temporal resolution and spatial signal quality by varying the sampling densities. The proposed method maintains the synergies of a temporal resolution that enables direct filtering of physiological artifacts for highest statistical power, and 3D read-outs with optimal use of encoding capabilities of multi-coil arrays for efficient sampling and high signal-to-noise ratio (SNR). METHODS: One- to four-shot interleaved spherical stack-of-spiral trajectories with repetition times from 96 to 352 ms at a nominal resolution of 3 mm using different sampling densities were compared for image quality and temporal SNR (tSNR). The one- and three-shot trajectories were employed in a resting state study for functional characterization. RESULTS: Compared to a previously described single-shot trajectory, denser sampled trajectories of the same type are shown to be less prone to blurring and off-resonance vulnerability that appear in addition to the variable density artifacts of the point spread function. While the multi-shot trajectories lead to a decrease in tSNR efficiency, the high SNR due to the 3D read-out, combined with notable increases in image quality, leads to superior overall results of the three-shot interleaved stack of spirals. A resting state analysis of 15 subjects shows significantly improved functional sensitivity in areas of high off-resonance gradients. CONCLUSION: Mild variable-density sampling leads to excellent tSNR behavior and no increased off-resonance vulnerability, and is suggested unless maximum temporal resolution is sought.

Improved 3D real-time MRI of speech production.

PURPOSE: To provide 3D real-time MRI of speech production with improved spatio-temporal sharpness using randomized, variable-density, stack-of-spiral sampling combined with a 3D spatio-temporally constrained reconstruction. METHODS: We evaluated five candidate (k, t) sampling strategies using a previously proposed gradient-echo stack-of-spiral sequence and a 3D constrained reconstruction with spatial and temporal penalties. Regularization parameters were chosen by expert readers based on qualitative assessment. We experimentally determined the effect of spiral angle increment and kz temporal order. The strategy yielding highest image quality was chosen as the proposed method. We evaluated the proposed and original 3D real-time MRI methods in 2 healthy subjects performing speech production tasks that invoke rapid movements of articulators seen in multiple planes, using interleaved 2D real-time MRI as the reference. We quantitatively evaluated tongue boundary sharpness in three locations at two speech rates. RESULTS: The proposed data-sampling scheme uses a golden-angle spiral increment in the kx -ky plane and variable-density, randomized encoding along kz . It provided a statistically significant improvement in tongue boundary sharpness score (P < .001) in the blade, body, and root of the tongue during normal and 1.5-times speeded speech. Qualitative improvements were substantial during natural speech tasks of alternating high, low tongue postures during vowels. The proposed method was also able to capture complex tongue shapes during fast alveolar consonant segments. Furthermore, the proposed scheme allows flexible retrospective selection of temporal resolution. CONCLUSION: We have demonstrated improved 3D real-time MRI of speech production using randomized, variable-density, stack-of-spiral sampling with a 3D spatio-temporally constrained reconstruction.

Self-Calibrating Wave-Encoded Variable-Density Single-Shot Fast Spin Echo Imaging.

BACKGROUND: It is highly desirable in clinical abdominal MR scans to accelerate single-shot fast spin echo (SSFSE) imaging and reduce blurring due to T2 decay and partial-Fourier acquisition. PURPOSE: To develop and investigate the clinical feasibility of wave-encoded variable-density SSFSE imaging for improved image quality and scan time reduction. STUDY TYPE: Prospective controlled clinical trial. SUBJECTS: With Institutional Review Board approval and informed consent, the proposed method was assessed on 20 consecutive adult patients (10 male, 10 female, range, 24-84 years). FIELD STRENGTH/SEQUENCE: A wave-encoded variable-density SSFSE sequence was developed for clinical 3.0T abdominal scans to enable high acceleration (3.5×) with full-Fourier acquisitions by: 1) introducing wave encoding with self-refocusing gradient waveforms to improve acquisition efficiency; 2) developing self-calibrated estimation of wave-encoding point-spread function and coil sensitivity to improve motion robustness; and 3) incorporating a parallel imaging and compressed sensing reconstruction to reconstruct highly accelerated datasets. ASSESSMENT: Image quality was compared pairwise with standard Cartesian acquisition independently and blindly by two radiologists on a scale from -2 to 2 for noise, contrast, confidence, sharpness, and artifacts. The average ratio of scan time between these two approaches was also compared. STATISTICAL TESTS: A Wilcoxon signed-rank tests with a P value under 0.05 considered statistically significant. RESULTS: Wave-encoded variable-density SSFSE significantly reduced the perceived noise level and improved the sharpness of the abdominal wall and the kidneys compared with standard acquisition (mean scores 0.8, 1.2, and 0.8, respectively, P < 0.003). No significant difference was observed in relation to other features (P = 0.11). An average of 21% decrease in scan time was achieved using the proposed method. DATA CONCLUSION: Wave-encoded variable-density sampling SSFSE achieves improved image quality with clinically relevant echo time and reduced scan time, thus providing a fast and robust approach for clinical SSFSE imaging. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 6 J. Magn. Reson. Imaging 2018;47:954-966.

B0-informed variable density trajectory design for enhanced correction of off-resonance effects in parallel transmission.

PURPOSE: To improve B1 and B0 inhomogeneity mitigation performance of spatially selective radio-frequency (RF) pulses in parallel transmission while decreasing RF pulse power. Further enhancement of off-resonance correction for rectilinear spoke-trajectory-based RF pulses with known residual geometric distortions after optimization. METHODS: The appropriate definition of the target magnetization pattern is discussed regarding the maximum physical excitation resolution. Furthermore, a novel variable-density trajectory design is introduced, which subsamples accrued B0 phase error elevations in k-space. A simulation study (echo-planar and spiral 2DRF) at different off-resonance levels and pulse acceleration factors was pursued using data from a whole-body 2-channel parallel transmit 3T MRI system. The new trajectory design for echo-planar 2DRF was validated in human in-vivo experiments. RESULTS: Proper target pattern definition can require spatial filtering, such that RF pulse optimization is prevented from lower excitation performance with significant higher RF power level. The new trajectory design proposed can considerably improve off-resonance compensation, while further reducing the RF power, e.g., 43% less RMSE with 79% less RF power for spoke based pulses. CONCLUSION: The proposed methods offer significant improvements of the excitation performance (homogeneity and acceleration), while significantly decreasing the RF power. Furthermore, single-channel transmit RF pulse performance can be similarly improved.

Shaped saturation with inherent radiofrequency-power-efficient trajectory design in parallel transmission.

PURPOSE: A target-pattern-driven (TD) trajectory design is introduced in combination with parallel transmit (pTX) radiofrequency (RF) pulses to provide localized suppression of unwanted signals. The design incorporates target-pattern and B1+ information to adjust denser sampling and coverage in k-space regions where the main pattern information lies. Based on this approach, two-dimensional RF spiral saturation pulses sensitive to RF power limits were applied in vivo for the first time. THEORY AND METHODS: The TD method was compared with two state-of-the-art spiral design methods. Simulations at different spatial fidelities, acceleration factors and anatomical regions were carried out for an eight-channel pTX 3 Tesla (T) coil. Human in vivo experiments were performed on a two-channel pTX 3T scanner saturating shaped patterns in the brain, heart, and thoracic spine. RESULTS: Using the TD trajectory, RF pulse power can be substantially reduced by up to 34% compared with other trajectory designs with the same spatial accuracy. Local and global specific absorption rates are decreased in most cases. CONCLUSION: The TD trajectory design uses available a priori information to enhance RF power efficiency and spatial response of the RF pulses. Shaped saturation pulses show improved spatial accuracy and saturation performance. Thus, RF pulses can be designed more efficiently and can be further accelerated.

Variable density sampling and non-Cartesian super-resolved reconstruction for spatiotemporally encoded single-shot MRI.

Spatiotemporally encoded (SPEN) single-shot MRI is an emerging ultrafast technique, which is capable of spatially selective acquisition and reduced field-of-view imaging. Compared to uniform sampling, variable density sampling has great potential in reducing aliasing artifacts and improving sampling efficiency. In this study, variable density spiral trajectory and non-Cartesian super-resolved (SR) reconstruction method are developed for SPEN MRI. The gradient waveforms design of spiral trajectory is mathematically described as an optimization problem subjected to the limitations of hardware. Non-Cartesian SR reconstruction with specific gridding method is developed to retrieve a resolution enhanced image from raw SPEN data. The robustness and efficiency of the proposed methods are demonstrated by numerical simulation and various experiments. The results indicate that variable density SPEN MRI can provide better spatial resolution and fewer aliasing artifacts compared to Cartesian counterpart. The proposed methods will facilitate the development of variable density SPEN MRI.