RESUMO
OBJECTIVES: To describe the surgical findings, histopathological features, and long-term outcome for a horse with parotid salivary carcinoma. STUDY DESIGN: Case report ANIMALS: Twelve year old American Quarter Horse gelding. METHODS: The gelding was presented for a 10 × 10 cm swelling below the base of the right ear. Ultrasonographic examination revealed a mass involving the right parotid salivary gland. Incisional biopsy was consistent with parotid carcinoma. The tumor was marginally excised. The lateral wall of the guttural pouch was excised with the mass and was reconstructed with a porcine small intestinal submucosal (SIS) sheet. Cisplatin beads were implanted in the wound bed prior to closure. Firocoxib (0.1 mg/kg orally, daily, every 24 h) treatment was initiated. RESULTS: Postoperative complications included right-sided facial nerve paralysis, difficulty with deglutition of fibrous feeds, and surgical site dehiscence. Wound healing was achieved by second intention. Partial improvement in nerve function was observed within the first 6 months. At 12 months postparotidectomy, no sign of tumor reoccurrence or metastatic disease was present, and the gelding returned to work. CONCLUSION: Partial parotid sialoadenectomy was performed with a favorable long-term outcome. Regional anatomic knowledge is crucial.
Assuntos
Carcinoma Ductal , Doenças dos Cavalos , Neoplasias Parotídeas , Procedimentos de Cirurgia Plástica/veterinária , Animais , Carcinoma Ductal/veterinária , Doenças dos Cavalos/cirurgia , Cavalos , Masculino , Neoplasias Parotídeas/cirurgia , Neoplasias Parotídeas/veterinária , Glândulas Salivares , SuínosRESUMO
A free-ranging juvenile California sea lion ( Zalophus californianus) stranded on the coast of Vancouver, British Columbia, with signs of lethargy and emaciation in April 2016. An asymmetrical skull with a prominent superficial cervical lymph node was found on initial assessment. Fine-needle aspirates and biopsies of the lymph node were consistent with neoplasia and the animal was humanely euthanized and presented for necropsy. A metastatic parotid gland adenocarcinoma was diagnosed with regional lymph node and pulmonary metastases. Local invasion of contiguous skeletal muscle, bone, ear, and tonsils was extensive and likely accounted for the unilateral craniofacial deformity. Neoplasia of nonurogenital origin in juvenile California sea lions are reported infrequently. This is the first case of a parotid carcinoma in a California sea lion.
Assuntos
Carcinoma/veterinária , Neoplasias Parotídeas/veterinária , Leões-Marinhos , Animais , Animais Selvagens , Carcinoma/patologia , Masculino , Neoplasias Parotídeas/patologiaRESUMO
Myoepitheliomas of the salivary glands have been described in laboratory mice, but not in rats. A 20-week-old Wistar (Han) female rat developed a white to grey firm mass at the left side of the neck. Histologically, the mass was unencapsulated and infiltrated the adjacent tissue. The tumour parenchyma was cell rich without acinar or tubular architecture. The tumour showed a palisading basal cell pattern adjacent to blood vessels. There were areas of necrosis filled with cellular debris. The tumour cells showed strong immunohistochemical labelling for pan-cytokeratin types I and II (AE1/AE3), pan-cytokeratin (cytokeratins 1, 5, 6 and 8), cytokeratin 5, cytokeratin 14, vimentin and podoplanin, and only very slight positivity for cytokeratin 8 in small areas. There was no expression of smooth muscle actin. Based on the histological appearance and the immunohistochemistry, the tumour was diagnosed as a malignant myoepithelioma of the parotid gland originating from the parotid duct.
Assuntos
Mioepitelioma/veterinária , Neoplasias Parotídeas/veterinária , Doenças dos Roedores/patologia , Animais , Feminino , Ratos , Ratos WistarRESUMO
INTRODUCTION: There is an important morbidity associated with parotidectomy. The most commonly reported permanent complication is facial nerve injury. Methylene blue staining has been used as an intra-operative tool to improve tissue visualisation and preserve facial nerve integrity. OBJECTIVES: To describe the functionality and feasibility of the use of methylene blue for parotidectomy in dogs. MATERIALS AND METHODS: Retrospective study included seven client-owned dogs that underwent parotidectomy after injection of methylene blue from 2016 to 2019 in a referral centre. Cross-sectional imaging was used to confirm parotid gland surgical disease and for staging purposes. All dogs underwent parotid resection and removal of the parotid duct after injection of methylene blue. Methylene blue was either administered via cannulation of the parotid duct or directly injected into the abnormal gland. RESULTS: In all cases, the gland stained dark blue within seconds without any evident leakage. Complete parotid gland resection and removal of the parotid duct was achieved successfully in all dogs with a mean surgical time of 97 minutes. Subjectively, the staining was useful to identify innervation outside the coloured gland and facilitated dissection. No complications, including facial nerve injury, were recorded. CLINICAL SIGNIFICANCE: Methylene blue staining for complete parotidectomy was feasible, rapid and easy in these dogs. It can be used as an indirect facial nerve identification technique, and can therefore facilitate dissection and possibly reduce the incidence of post-operative facial nerve paralysis.
Assuntos
Doenças do Cão , Neoplasias Parotídeas , Animais , Doenças do Cão/cirurgia , Cães , Azul de Metileno , Glândula Parótida/cirurgia , Neoplasias Parotídeas/veterinária , Complicações Pós-Operatórias/prevenção & controle , Complicações Pós-Operatórias/veterinária , Estudos RetrospectivosRESUMO
A 7-year-old male cavalier King Charles spaniel was presented with a cervical subcutaneous mass. The mass had a multilobular growth pattern and each individual lobule contained ductal epithelial cells and myoepithelial cells surrounding the ductal cells. Immunohistochemically, the ductal epithelial cells were positive for cytokeratin (CK) 7 and CAM5.2 and the myoepithelial cells were positive for α-smooth muscle actin and p63. Both types of cells were positive for CK14, a myoepithelial cell marker. Ultrastructurally, the ductal epithelial cells were attached by desmosomes and contained abundant intracytoplasmic tonofilaments. Some ductal epithelial cells contained myofilaments characteristic of myoepithelial cells. Based on these findings, a diagnosis of epithelial-myoepithelial carcinoma was made. It is presumed that the tumour originated from an intercalated duct in a parotid salivary gland.
Assuntos
Doenças do Cão/patologia , Mioepitelioma/veterinária , Neoplasias Parotídeas/veterinária , Animais , Cães , MasculinoRESUMO
The opossum (family Didelphidae) is a marsupial endemic to the Americas. Apart from the South American short-tailed opossum (Monodelphis domestica) and the Virginia opossum (Didelphis virginiana), there is considerable lack of knowledge about the health and diseases of most opossum species. Among these, the big-eared opossum (Didelphis aurita) is found in Argentina, Brazil and Paraguay. Natural and experimental studies have shown this species to be susceptible to infectious agents with zoonotic potential and the animals may play a role in transmission of such agents. However, neoplasia appears to be uncommon in this species. We describe the gross, microscopical and immunohistochemical features of a parotid salivary gland basal cell adenocarcinoma in a free-living big-eared opossum. This case represents the first report of salivary gland neoplasia in opossums.
Assuntos
Adenocarcinoma/veterinária , Didelphis , Neoplasias Parotídeas/veterinária , Animais , FemininoRESUMO
Pleomorphic adenomas of the salivary gland were diagnosed in two dogs. The tumours were single, firm and well circumscribed, with a smooth cut surface. Metastatic tumours were not detected. Histopathological examination revealed that the tumours contained multiple cysts lined with luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues. Immunohistochemical examination demonstrated labelling of luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues with antibodies to cytokeratin LU-5, AE1/AE3, CK-14, CALP, a-SMA, vimentin, GFAP, and S-100. Labelling for GFAP indicated stromal transformation into myxoid and chondroid tissues.
Assuntos
Adenoma Pleomorfo/veterinária , Doenças do Cão/patologia , Neoplasias Parotídeas/veterinária , Neoplasias da Glândula Sublingual/veterinária , Adenoma Pleomorfo/metabolismo , Adenoma Pleomorfo/patologia , Animais , Biomarcadores Tumorais/metabolismo , Intervalo Livre de Doença , Doenças do Cão/metabolismo , Cães , Técnicas Imunoenzimáticas/veterinária , Masculino , Neoplasias Parotídeas/metabolismo , Neoplasias Parotídeas/patologia , Glândulas Salivares/patologia , Glândulas Salivares/cirurgia , Neoplasias da Glândula Sublingual/metabolismo , Neoplasias da Glândula Sublingual/patologiaRESUMO
Salivary gland neoplasms in cattle are rarely reported. Three parotid gland carcinomas from slaughter cows are described. Based on light microscopic and ultrastructural appearances the neoplasms were classified as pleomorphic carcinomas in Cows 1 and 2 and as a squamous cell carcinoma in Cow 3.
Assuntos
Doenças dos Bovinos/patologia , Neoplasias Parotídeas/veterinária , Animais , Bovinos , Feminino , Metástase Neoplásica/patologia , Neoplasias Parotídeas/ultraestruturaRESUMO
A salivary gland adenocarcinoma in a white Swiss mouse used in a titration of the scrapie agent is reported. The neoplasm originated from the serous cells of the parotid salivary gland. Retroviral particles were detected in the neoplastic salivary gland cells by electron microscopy.
Assuntos
Adenocarcinoma/veterinária , Camundongos , Neoplasias Parotídeas/veterinária , Doenças dos Roedores/patologia , Adenocarcinoma/patologia , Animais , Neoplasias Parotídeas/patologiaRESUMO
The nude mouse was used to evaluate transplantation of feline tumors and subsequent doxorubicin chemotherapy. Three mammary gland adenocarcinomas and one salivary gland adnoecarcinoma were readily transplanted. All were successfully passed at least once. The two sarcomas, a fibrosarcoma and a malignant hemangioendothelioma, failed to grow when transplanted. Growth rates for the adenocarcinomas appeared to be specific for individual tumors. Generally, tumor weights increased five to eight times by days 40 to 50. Structural changes were not observed histopathologically in tumors transplanted several times. When doxorubicin was given intraperitoneally (1 mg/kg of body weight) weekly for 6 weeks to nude mice with transplanted feline mammary gland adenocarcinoma, there was no significant difference (P less than 0.05) in weights of tumors of experimental (n = 150 and control (n = 10) mice.
Assuntos
Adenocarcinoma/veterinária , Fibrossarcoma/veterinária , Hemangioendotelioma/veterinária , Neoplasias Mamárias Experimentais , Neoplasias Parotídeas/veterinária , Doenças dos Roedores/cirurgia , Neoplasias Cutâneas/veterinária , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/cirurgia , Animais , Doxorrubicina/uso terapêutico , Feminino , Fibrossarcoma/tratamento farmacológico , Fibrossarcoma/cirurgia , Hemangioendotelioma/tratamento farmacológico , Hemangioendotelioma/cirurgia , Masculino , Neoplasias Mamárias Experimentais/tratamento farmacológico , Neoplasias Mamárias Experimentais/cirurgia , Camundongos , Camundongos Nus , Transplante de Neoplasias , Neoplasias Parotídeas/tratamento farmacológico , Neoplasias Parotídeas/cirurgia , Doenças dos Roedores/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/cirurgia , Timectomia/veterináriaRESUMO
A spontaneous parotid gland tumor with histomorphologic features characteristic of cystic and papillary growth was found in a 72-week-old F344 rat. The tumor had a prominent cystic appearance and invasive growth into the dermis beyond the muscular layer of the skin. The cyst walls were lined by a single layer of cuboidal to tall columnar epithelium with prominent papillary projections continuous with the cyst lining. The tumor cells had mucoid, pale cytoplasm and medium to large nuclei. The myoepithelium did not appear to be associated with the tumor cysts and the papillae. Atrophic parotid gland tissues were seen between cysts and in the periphery of the cystic lesions. In light of these findings, the tumor was diagnosed as papillary cystadenocarcinoma of parotid gland; this is the first description of a salivary gland papillary cystadenocarcinoma in a rat.
Assuntos
Cistadenocarcinoma Papilar/veterinária , Neoplasias Parotídeas/veterinária , Doenças dos Roedores/patologia , Animais , Animais de Laboratório , Cistadenocarcinoma Papilar/patologia , Feminino , Neoplasias Parotídeas/patologia , Ratos , Ratos Endogâmicos F344RESUMO
A case of primary parotid salivary gland adenocarcinoma is described in a three-year-old entire female great dane. The presenting complaint was sudden onset blindness concomitant with the development of bilateral hyphaema and anterior uveitis. A soft-tissue swelling of the left subaural region and right forelimb lameness were also present. A definitive diagnosis of primary parotid salivary gland adenocarcinoma with bilateral ocular metastases was made on post mortem examination. Metastases were also present in the right proximal humerus, left and right prescapular lymph nodes, left axillary lymph node, left retropharyngeal lymph node, bronchial lymph nodes and all lung lobes.
Assuntos
Adenocarcinoma/veterinária , Neoplasias Ósseas/veterinária , Doenças do Cão/diagnóstico , Neoplasias Oculares/veterinária , Neoplasias Parotídeas/veterinária , Adenocarcinoma/diagnóstico , Adenocarcinoma/patologia , Animais , Biópsia , Cegueira/etiologia , Cegueira/veterinária , Neoplasias Ósseas/secundário , Diagnóstico Diferencial , Doenças do Cão/etiologia , Doenças do Cão/patologia , Cães , Neoplasias Oculares/diagnóstico , Neoplasias Oculares/secundário , Feminino , Úmero , Hifema/etiologia , Hifema/veterinária , Coxeadura Animal/etiologia , Neoplasias Pulmonares/secundário , Neoplasias Pulmonares/veterinária , Linfoma/etiologia , Linfoma/veterinária , Neoplasias Parotídeas/diagnóstico , Neoplasias Parotídeas/patologia , Uveíte Anterior/etiologia , Uveíte Anterior/veterináriaAssuntos
Doenças do Gato/patologia , Cistadenocarcinoma/veterinária , Glândula Parótida/patologia , Neoplasias Parotídeas/veterinária , Animais , Doenças do Gato/cirurgia , Gatos , Cistadenocarcinoma/patologia , Cistadenocarcinoma/cirurgia , Masculino , Glândula Parótida/cirurgia , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/cirurgiaRESUMO
Schwannomas arising in the parotid gland are rare in man and are not documented in domestic animals. This report describes the clinical, morphological and immunohistochemical findings of a benign schwannoma in the parotid gland of a 12-year-old warmblood gelding. A slow-growing mass was surgically excised from the parotid gland and did not recur within the following 6 months. The tumour was well circumscribed and was composed of densely packed spindle cells partly arranged in an Antoni A pattern and intermixed with hypocellular areas resembling the Antoni B pattern. Tumour cells expressed vimentin, S100 protein, glial fibrillary acidic protein and variably neuron-specific enolase. Less than 5% of the neoplastic cells were immunolabelled with the proliferation marker Ki67. Although malignant melanomas frequently involve the parotid gland in horses, schwannomas should be included in the differential diagnosis of parotid masses.
Assuntos
Doenças dos Cavalos/patologia , Neurilemoma/veterinária , Neoplasias Parotídeas/veterinária , Animais , Biomarcadores Tumorais , Proteína Glial Fibrilar Ácida/metabolismo , Doenças dos Cavalos/metabolismo , Doenças dos Cavalos/cirurgia , Cavalos , Masculino , Neurilemoma/metabolismo , Neurilemoma/patologia , Neurilemoma/cirurgia , Neoplasias Parotídeas/metabolismo , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/cirurgia , Fosfopiruvato Hidratase/metabolismo , Resultado do Tratamento , Vimentina/metabolismoRESUMO
A 6-year-old Girolando dairy cow was presented for evaluation of a large subcutaneous facial mass. Fine-needle aspirates of the mass contained many neoplastic cells with high nuclear:cytoplasmic ratios arranged in sheets and loosely cohesive clusters with streaming erythrocytes and neutrophils in the background. Neoplastic cells were 13-25 µm in diameter and were round to cuboidal with variably distinct borders. Based on the signalment, anatomic location, and cytologic findings, differential diagnoses included salivary adenocarcinoma, squamous cell carcinoma, and mucoepidermoid carcinoma. The cow was euthanized and a necropsy was performed. The primary neoplasm arose from the left parotid salivary gland and meastatic tumor was found in the regional lymph nodes and lung. Histologically, the tumor was composed of anastomosing and irregular solid islets surrounded by scant stroma. Cells were negative for periodic acid-Schiff (PAS), PAS-diastase, and Alcian blue pH 2.5 stains, used to detect mucin. On immunohistochemical analysis, neoplastic luminal salivary gland cells expressed cytokeratin, but not S100, α-smooth muscle actin, or vimentin. Peripheral cells of neoplastic islets were immunoreactive for p63. The final diagnosis was nonsecretory adenocarcinoma of the parotid salivary gland.
Assuntos
Adenocarcinoma/veterinária , Doenças dos Bovinos/patologia , Neoplasias Pulmonares/veterinária , Glândula Parótida/patologia , Neoplasias Parotídeas/veterinária , Adenocarcinoma/patologia , Animais , Biópsia por Agulha Fina , Bovinos , Diagnóstico Diferencial , Face/patologia , Evolução Fatal , Feminino , Queratinas/metabolismo , Pulmão/patologia , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/secundário , Linfonodos/patologia , Metástase Linfática , Neoplasias Parotídeas/patologiaAssuntos
Doenças do Cão/diagnóstico , Lipoma/veterinária , Neoplasias Parotídeas/veterinária , Ductos Salivares , Animais , Doenças do Cão/etiologia , Cães , Feminino , Lipoma/complicações , Lipoma/diagnóstico , Neoplasias Parotídeas/complicações , Neoplasias Parotídeas/diagnóstico , Parotidite/etiologia , Parotidite/veterinária , Doenças das Glândulas Salivares/etiologia , Doenças das Glândulas Salivares/veterináriaAssuntos
Doenças dos Bovinos/patologia , Linfoma não Hodgkin/veterinária , Regressão Neoplásica Espontânea/veterinária , Neoplasias Cutâneas/veterinária , Neoplasias do Timo/veterinária , Animais , Bovinos , Contagem de Leucócitos , Linfonodos/patologia , Linfócitos , Linfoma Difuso de Grandes Células B/patologia , Linfoma Difuso de Grandes Células B/veterinária , Recidiva Local de Neoplasia/veterinária , Regressão Neoplásica Espontânea/patologia , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/veterinária , Neoplasias Cutâneas/patologia , Neoplasias do Timo/patologiaRESUMO
T-cell-rich B-cell lymphoma is a neoplasm recognized in humans in which a neoplastic proliferation of large B lymphocytes is present amid a background of reactive T lymphocytes. A 13-year-old Domestic Shorthair cat developed a mass in the region of the left parotid gland. Histologically, the mass was composed of scattered large atypical cells within a dense background of uniform small lymphoid cells. Immunohistochemically, the large cells were uniformly labeled using antiserum directed against the B-lymphocyte marker BLA.36, whereas labeling of nearly all of the small cells was limited to the T-lymphocyte marker CD3. The histomorphologic and immunohistochemical features of this unique feline neoplasm are characteristic of T-cell-rich B-cell lymphoma of humans.
Assuntos
Doenças do Gato/patologia , Linfoma de Células B/patologia , Linfoma de Células B/veterinária , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/veterinária , Linfócitos T/patologia , Animais , GatosRESUMO
Seven of approximately 200 rnu/rnu nude rats developed adenocarcinomas of the parotid gland. The malignant neoplasms ranged from well differentiated (grade 1) to poorly differentiated (grade 3) adenocarcinomas. The age of affected rats varied from 6 months to 1 year. The appearance of salivary gland adenocarcinomas in rnu/rnu rats is unusual and may have important implications for human tumor xenotransplantation in these animals.