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1.
J Oral Implantol ; 18(4): 379-82, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1298822

RESUMO

Among some patients, regardless of age, the jaw loses bone mass, leading to loosening and falling out of otherwise healthy teeth. This study seeks to establish whether this bone loss is associated with the metabolic manifestations of other forms of localized decalcifications, such as in Paget's disease, or with generalized osteoporosis. Sixteen women being fitted with dental implants to compensate for bone losses provided 24-hour urine samples for the quantitative determination of calcium and galactosyl hydroxylysine, a bone collagen metabolite. These patients provided demographic information, relevant medical, dental, and dietary history, a profile of their current medications, and the status of their smoking and exercise habits. Urinary excretion of galactosyl hydroxylysine, which is increased in the presence of progressive increased bone resorption, remained within normal values in the patients of this study. These results suggest that the thinning of the jaw bones and subsequent tooth loss of these subjects were osteoporotic processes too limited and too localized to produce measurable increases in urinary bone metabolites.


Assuntos
Perda do Osso Alveolar/metabolismo , Osteoporose/complicações , Perda de Dente/etiologia , Adulto , Idoso , Perda do Osso Alveolar/etiologia , Perda do Osso Alveolar/urina , Cálcio/urina , Distribuição de Qui-Quadrado , Creatinina/urina , Estrogênios/metabolismo , Feminino , Humanos , Hidroxilisina/análogos & derivados , Hidroxilisina/urina , Pessoa de Meia-Idade , Boca Edêntula/metabolismo , Osteoporose/metabolismo , Análise de Regressão
2.
Clin Oral Implants Res ; 12(2): 109-14, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11251659

RESUMO

The purpose of this study was to determine the effect of bisphosphonate on alveolar bone resorption in experimentally-induced peri-implantitis in beagle dogs. Experimental peri-implantitis was induced by ligation around the abutments, 6 months after placement of a fixture. Pamidronate (0.6 mg/kg) was injected intramuscularly every 3 days into each of 5 dogs. Another 5 dogs served as the control group and were injected with saline only. Peripheral blood and urine samples were collected every week up to 12 weeks after placement of the ligature. Standard X-rays were taken every week. Urinary deoxypyridinoline (DPD) and serum osteocalcin (OC) were evaluated by ELISA as markers of alveolar bone remodeling. X-ray films were analyzed with a computer image analyzer. After 12 weeks, the bone level was measured after removal of the gingival flap. The distance between the top surface of the fixture and the fundus of the defect was significantly lower in the Pamidronate group (1.59+/-0.55 mm, mean+/-SD) than in the control group (2.41+/-0.48 mm). Bone density analyzed from the X-ray films was significantly higher in the bisphosphonate group (69.2+/-8.7%, mean+/-SD) than in the control group (50.3+/-12.8%) after 2 to 8 weeks compared with the baseline value (100%). OC and DPD levels fluctuated during the experimental period. These findings suggest that bisphosphonate inhibits the progression of alveolar bone resorption during ligature-induced peri-implantitis in dogs.


Assuntos
Perda do Osso Alveolar/prevenção & controle , Anti-Inflamatórios não Esteroides/uso terapêutico , Implantes Dentários/efeitos adversos , Difosfonatos/uso terapêutico , Periodontite/etiologia , Perda do Osso Alveolar/sangue , Perda do Osso Alveolar/etiologia , Perda do Osso Alveolar/urina , Aminoácidos/urina , Animais , Implantação Dentária Endóssea/efeitos adversos , Cães , Ensaio de Imunoadsorção Enzimática , Osteocalcina/sangue , Pamidronato , Periodontite/sangue , Periodontite/urina , Estatísticas não Paramétricas
3.
Calcif Tissue Int ; 72(4): 491-7, 2003 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-12574873

RESUMO

Osteoclastic activation rather than suppression of bone formation has been suggested to be the dominant process leading to bone loss in rheumatoid arthritis (RA). Although many studies have already shown the correlation of urinary pyridinoline (PYD) and deoxypyridinoline (DPD) levels with RA-related bone loss, urinary cross-linked N-telopeptides of type I collagen (NTx), a more specific marker of bone-derived type I collagen fragments in urine than urinary PYD and DPD in RA, has not been adequately studied. The purpose of the present study was to determine clinical factors that are associated with an increase in urinary NTx levels in patients with RA. One hundred and eighty-four patients with RA and 185 sex- and age-matched controls were enrolled in the study: 71 men, 37-68 years of age (RA: 31, controls: 40); 129 premenopausal women, 30-48 years of age (RA: 67, controls: 62), and 169 postmenopausal women, 48-69 years of age (RA: 86, controls: 83). The correlations of urinary NTx levels, measured by enzyme-linked immunosorbent assay with anatomic grade in the wrist, functional class, duration of disease, steroid use, modified health assessment questionnaire (HAQ) score for the upper and lower extremities, the levels of serum c-reactive protein and rheumatoid factor (RF), erythrocyte sedimentation rate, and/or years since menopause were examined by multiple regression analysis. Urinary NTx levels (nmol BCE/mmol Cr) did not differ significantly between men with RA and controls (53.2 +/- 29.6 vs 41.0 +/- 19.6, respectively), whereas urinary NTx levels were significantly higher in pre- and postmenopausal women with RA than in respective controls (premenopausal women: 57.1 +/- 36.6 vs 42.3 +/- 21.3, P <0.01; women: 76.2 +/- 27.3 vs 57.1 +/- 28.3, P <0.001). In men with RA, no clinical factors were significantly correlated with urinary NTx levels. In premenopausal women with RA, functional class, HAQ score for the upper extremities, and RF were significantly correlated with urinary NTx levels (all P <0.05); in postmenopausal women with RA, functional class and RF were significantly correlated with urinary NTx levels (both P <0.05). These findings suggest that urinary NTx levels were significantly higher only in women with RA than in age-matched controls, and a RA-related increase in urinary NTx levels may be associated with physical inactivity and disease activity.


Assuntos
Perda do Osso Alveolar/diagnóstico , Perda do Osso Alveolar/urina , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/urina , Colágeno Tipo I/urina , Colágeno/urina , Peptídeos/urina , Adulto , Idoso , Envelhecimento/metabolismo , Perda do Osso Alveolar/fisiopatologia , Artrite Reumatoide/fisiopatologia , Biomarcadores/urina , Índice de Massa Corporal , Peso Corporal/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Aptidão Física/fisiologia , Pós-Menopausa/metabolismo , Valor Preditivo dos Testes , Caracteres Sexuais , Estatística como Assunto
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