Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención: un estudio de casos y controles / Factors associated to the occurrence of cleft lip and palate in newborns in a tertiary care Peruvian hospital: a case-control study
Plasencia-Dueñas, EA; Díaz-Vélez, C; Dueñas-Roque, MM.
Acta Med Peru
; 37(3): 304-311, 7 oct. 2020.
Article
in Spanish
| MMyP | ID: biblio-1127894
Objective:
to identify factors associated to the occurrence of cleft lip and/or palate in newborns in Edgardo Rebagliati-Martins National Hospital in Lima, Peru, during the time period from November 2012 until December 2016. Materials andmethods:
this is an analytical observational paired case-control study, with data from the Collaborative Latin-American Study of Congenital Malformations. Sixty-one cases and sixty-one controls were analyzed. The dependent variable was the presence of cleft lip and/or palate. Clinical, epidemiological, obstetric, and prenatal variables were also analyzed.Results:
cleft lip/palate with complete extension predominantly in males was the most frequent form, and it was present in 36 neonates (59%), 44 of all children in the sample (75.9%) had normal karyotype, and 40 did not have a prenatal diagnosis (65.6%). Associated malformations most frequently observed were 27 facial cases (44.2%), followed by cardiac malformations (29.6%). A statistical model using multivariate analysis was built on, and this comprised three variables chronic disease during pregnancy (odds ratio [OR] 3.8; 95% confidence interval [CI] 1.1113.8), maternal age more than 35 years (OR 6.85; 95% CI 2.6917.43), and family history (OR 14.5; 95% CI 1.68125.56).Conclusions:
chronic diseases during pregnancy, advanced maternal age, and family history were factors that increased the frequency of cleft lip and/or palate. (AU)
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