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Involvement of eicosanoids and PAF in immune-coplex alveolitis
Lima, W. Tavares de; Teixeira, C. F. P; Sirois, P; Jancar, S.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;22(6): 745-8, June 1989. tab, ilus
Article in En | LILACS | ID: lil-75219
Responsible library: BR26.1
ABSTRACT
An immune-complex-mediated hypersensitivity reaction induced in the rat lung was followed by release of the eicosanoids thromboxane, prostaglandin E2 and leukotriene B4 into bronchoalveolar space. Concomitantly, there was a decrease in the number of circulating platelets. The thrombocytopenia was inhibited by a cyclo-oxygenase inhibitor (indomethacin), a platelet activating factor (PAF) antagonist (BN-52021) and an inhibitor of thromboxane (econazozle), but was not affected by a lipoxygenase inhibitor (NDGA). These results suggest the involvement of eicosanoids and PAF in the immune complex hypersensitivity reaction in the rat lung and indicate the ocurrence of interactions between PAF and thromboxane
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Collection: 01-internacional Database: LILACS Main subject: Bronchoalveolar Lavage Fluid / Platelet Activating Factor / Thromboxanes / Alveolitis, Extrinsic Allergic / Antigen-Antibody Complex Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1989 Type: Article / Congress and conference / Project document
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Collection: 01-internacional Database: LILACS Main subject: Bronchoalveolar Lavage Fluid / Platelet Activating Factor / Thromboxanes / Alveolitis, Extrinsic Allergic / Antigen-Antibody Complex Limits: Animals Language: En Journal: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Journal subject: BIOLOGIA / MEDICINA Year: 1989 Type: Article / Congress and conference / Project document