Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling.
Proc Natl Acad Sci U S A
; 96(6): 2627-32, 1999 Mar 16.
Article
in En
| MEDLINE
| ID: mdl-10077561
ABSTRACT
Disaggregation of the spherical nuclear bodies termed promyelocytic (PML) oncogenic domains (PODs) is a characteristic of acute promyelocytic leukemia. Here, we demonstrate that the cAMP enhancer binding protein (CREB)-binding protein (CBP) associates with PML in vitro and is recruited to the PODs in vivo. Through its association with CBP, wild-type PML dramatically stimulates nuclear receptor transcriptional activity. These results demonstrate that a fraction of CBP is compartmentalized to the POD through its association with PML and thus suggest that PML and other POD-associated proteins may play an unexpectedly broad role in aspects of transcriptional regulation and human disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Nuclear Proteins
/
Leukemia, Promyelocytic, Acute
/
Trans-Activators
/
Neoplasm Proteins
Limits:
Humans
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
1999
Type:
Article
Affiliation country:
United States