Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.

Chapman, P F; White, G L; Jones, M W; Cooper-Blacketer, D; Marshall, V J; Irizarry, M; Younkin, L; Good, M A; Bliss, T V; Hyman, B T; Younkin, S G; Hsiao, K K

Chapman, P F; White, G L; Jones, M W; Cooper-Blacketer, D; Marshall, V J; Irizarry, M; Younkin, L; Good, M A; Bliss, T V; Hyman, B T; Younkin, S G; Hsiao, K K.

Affiliation

Chapman PF; Cardiff School of Biosciences, Cardiff University, Wales, UK.

Nat Neurosci ; 2(3): 271-6, 1999 Mar.

Article in En | MEDLINE | ID: mdl-10195221

Subject(s)

Aging/physiology; Aging/psychology; Amyloid beta-Protein Precursor/metabolism; Learning/physiology; Neuronal Plasticity/physiology; Synapses/physiology; Amyloid beta-Protein Precursor/genetics; Animals; Dentate Gyrus/physiology; Hippocampus/physiology; Humans; Long-Term Potentiation/physiology; Memory/physiology; Mice; Mice, Transgenic/genetics; Space Perception/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Aging / Amyloid beta-Protein Precursor / Learning / Neuronal Plasticity Limits: Animals / Humans Language: En Journal: Nat Neurosci Journal subject: NEUROLOGIA Year: 1999 Type: Article Affiliation country: United kingdom

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