Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.
Int J Radiat Oncol Biol Phys
; 44(1): 201-10, 1999 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-10219815
ABSTRACT
PURPOSE:
The irradiation system and biophysical characteristics of carbon beams are examined regarding radiation therapy. METHODS AND MATERIALS An irradiation system was developed for heavy-ion radiotherapy. Wobbler magnets and a scatterer were used for flattening the radiation field. A patient-positioning system using X ray and image intensifiers was also installed in the irradiation system. The depth-dose distributions of the carbon beams were modified to make a spread-out Bragg peak, which was designed based on the biophysical characteristics of monoenergetic beams. A dosimetry system for heavy-ion radiotherapy was established to deliver heavy-ion doses safely to the patients according to the treatment planning. A carbon beam of 80 keV/microm in the spread-out Bragg peak was found to be equivalent in biological responses to the neutron beam that is produced at cyclotron facility in National Institute Radiological Sciences (NIRS) by bombarding 30-MeV deuteron beam on beryllium target. The fractionation schedule of the NIRS neutron therapy was adapted for the first clinical trials using carbon beams.RESULTS:
Carbon beams, 290, 350, and 400 MeV/u, were used for a clinical trial from June of 1994. Over 300 patients have already been treated by this irradiation system by the end of 1997.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiotherapy
/
Carbon
/
Heavy Ion Radiotherapy
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Int J Radiat Oncol Biol Phys
Year:
1999
Type:
Article
Affiliation country:
Japan