[Characteristics of the antivitamin effect of pyriditol, a disulfide pyridoxine derivative, on animal body]. / Kharakteristika antivitaminnogo deistviia disul'fidnogo proizvodnogo piridoksina-piriditola-na zhivotnyi organizm
Farmakol Toksikol
; 39(3): 308-11, 1976.
Article
in Ru
| MEDLINE
| ID: mdl-1026514
ABSTRACT
Intraperitoneal administration of disulphide pyridoxine (pyriditol) to albino mice in a dose of 300 mg/kg brings down the GABA level and the GABA-transaminase activity in the brain, the glutamic acid content and the glutamate-decarboxylase activity remaining unchanged. In the liver and, especially, in the kidneys of test animals the activity of aspartate-and alanine-aminotransferase goes down. The diurnal urinary output of the animals shows a decreased passage of 4-pyridoxic acid. These results are interpreted to be consequent upon the antivitamin action of pyriditol with respect to pyridoxine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridines
/
Pyridoxine
/
Pyrithioxin
Limits:
Animals
Language:
Ru
Journal:
Farmakol Toksikol
Year:
1976
Type:
Article