Characterization and preliminary evaluation of ester-modified technetium-99m SNS/S mixed ligand complexes as potential brain perfusion agents.
Nucl Med Biol
; 26(3): 297-304, 1999 Apr.
Article
in En
| MEDLINE
| ID: mdl-10363801
ABSTRACT
Two novel [99mTc](SNS/S) mixed ligand complexes carrying a pendant ester function on the monothiolate coligand were synthesized. The corresponding oxorhenium and [99gTc]oxotechnetium complexes prepared at the macroscopic level and chemically characterized were used for structure assignment of [99mTc](SNS/S) complexes prepared at the nanomolar level. Enzymatic hydrolysis of the pendant ester group of [99mTc](SNS/S) mixed ligand complexes by esterase was investigated in vitro and compared with that of the ethyl cysteinate dimer, [99mTc]ECD. Preliminary biodistribution data in mice shows that the complexes are lipophilic and exhibit significant initial uptake in rodent brain.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Technetium Tc 99m Sulfur Colloid
/
Brain
/
Tin Compounds
/
Radiopharmaceuticals
Limits:
Animals
Language:
En
Journal:
Nucl Med Biol
Journal subject:
BIOLOGIA
/
MEDICINA NUCLEAR
Year:
1999
Type:
Article
Affiliation country:
Greece