Interleukin-4 receptor-directed cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model.

Husain, S R; Kreitman, R J; Pastan, I; Puri, R K

Husain, S R; Kreitman, R J; Pastan, I; Puri, R K.

Affiliation

Husain SR; Laboratory of Molecular Tumor Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland 20892, USA.

Nat Med ; 5(7): 817-22, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10395328

Subject(s)

ADP Ribose Transferases; Acquired Immunodeficiency Syndrome/complications; Bacterial Toxins; Exotoxins/therapeutic use; Immunotoxins/therapeutic use; Interleukin-4/therapeutic use; Receptors, Interleukin-4/physiology; Sarcoma, Kaposi/drug therapy; Virulence Factors; Animals; Cachexia/prevention & control; Humans; Lymphopenia/prevention & control; Mice; Mice, Nude; Peptide Fragments/therapeutic use; Receptors, Interleukin-4/drug effects; Recombinant Fusion Proteins/therapeutic use; Sarcoma, Kaposi/etiology; Sarcoma, Kaposi/immunology; Sarcoma, Kaposi/physiopathology; Transplantation, Heterologous; Tumor Cells, Cultured; Pseudomonas aeruginosa Exotoxin A

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Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Kaposi / Bacterial Toxins / Immunotoxins / Acquired Immunodeficiency Syndrome / Interleukin-4 / ADP Ribose Transferases / Receptors, Interleukin-4 / Virulence Factors / Exotoxins Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1999 Type: Article Affiliation country: United States

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