Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.

Riballo, E; Critchlow, S E; Teo, S H; Doherty, A J; Priestley, A; Broughton, B; Kysela, B; Beamish, H; Plowman, N; Arlett, C F; Lehmann, A R; Jackson, S P; Jeggo, P A

Riballo, E; Critchlow, S E; Teo, S H; Doherty, A J; Priestley, A; Broughton, B; Kysela, B; Beamish, H; Plowman, N; Arlett, C F; Lehmann, A R; Jackson, S P; Jeggo, P A.

Affiliation

Riballo E; MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK.

Curr Biol ; 9(13): 699-702, 1999 Jul 01.

Article in En | MEDLINE | ID: mdl-10395545

Subject(s)

DNA Ligases/genetics; DNA Repair; DNA-Binding Proteins/metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; Radiation Tolerance/genetics; Animals; Blotting, Western; Cell Line, Transformed; DNA Ligase ATP; DNA Ligases/metabolism; DNA Repair/genetics; DNA-Activated Protein Kinase; DNA-Binding Proteins/genetics; Fibroblasts/radiation effects; Humans; Mutation; Nuclear Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma/radiotherapy; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Rabbits; Radiation, Ionizing; Sequence Analysis, DNA

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Collection: 01-internacional Database: MEDLINE Main subject: DNA Ligases / Radiation Tolerance / DNA-Binding Proteins / DNA Repair / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Curr Biol Journal subject: BIOLOGIA Year: 1999 Type: Article Affiliation country: United kingdom

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